Health Products Distributors

Health Products Distributors

  • REJUVENATE! BERRIES & HERBS – SUPERFOOD FORMULA UPDATED

    Dr. Hank Liers, PhD Rejuvenate! Berries & Herbs superfoodToday I talk about my REJUVENATE!™ BERRIES & HERBS high-RNA superfood. I designed it to be a super-delicious, intensely berry flavored superfood with no greens. I put in real organic berries—BLUEBERRY, STRAWBERRY, RASPBERRY, and CRANBERRY—so it bursts with true berry flavors! I recently updated the formula, so it is is more delicious and nutritious than ever.

    REJUVENATE! BERRIES & HERBS – A COMPLETE SUPERFOOD

    Rejuvenate! Berries & Herbs is a delicious high-RNA (390 mg), high-protein (14.6 g) (organic pea and organic rice), high-antioxidant (ORAC value of 14,000+), high fiber (13 g) superfood with a creamy smoothness and rich berry flavor that tastes beyond great! It also boosts health with a complete multivitamin-multimineral sub-formula and important cell-protective herbs (herbal complex) that includes ginger, dandelion, burdock, turmeric, green tea extract, astragalus, and many other health-building herbs.

    How to use Rejuvenate! Berries & Herbs? Just mix in water, juices, nut milks, or smoothies to create a drink with superb health benefits. Or use it creatively in foods, such as nut butters, salads, fruits, sauce/dressings, or desserts. It tastes so good, some people like to eat it by itself—or mixed in a little purified water.

    HEALTHY AND HIGH-RNA BY DESIGN

    Rejuvenate! Berries & Herbs is among HPDI's premier high-RNA superfoods. That is, Rejuvenate! Berries & Herbs is one of three Rejuvenate! superfoods, which are the world's first—and only—dedicated high-RNA superfoods. High-RNA nutrition means high in dietary nucleic acids, which Dr. Benjamin S. Frank considers to be essential nutrients, like vitamins and minerals (Dietary Nucleic Acid Nutrition & Therapy). Dr. Frank's studies demonstrate many benefits of nucleic acids, including: greater energy, endurance, functional strength, easier breathing (anti-anoxic effect), as well as cardiovascular benefits and cosmetic benefits (smoother skin and a more youthful appearance).

    Highlights of Rejuvenate! Berries & Herbs:

    • Delicious Berry Flavor Bursts with Real Organic Berries!
    • Powerful Organic and Wildcrafted Cell-Protective Herbs
    • High ORAC Value (~14,270 units)
    • 390 mg Dietary Nucleic Acids (RNA/DNA) from Vegetarian Sources
    • Multiple Prebiotics Supporting your Microbiome
    • Gluten Free, Vegan/Vegetarian, No Artificial Ingredients
    • Mixes Well with other Rejuvenate!™ Superfoods

    My updated formula (as of 12/2018) features, per serving:

    – 2.6 g more protein (14.6 g total)
    – Very little sugar (1.2 g total)
    – 7.0 g more fiber (13 g total)
    – 100 mg of organic BiAloe® aloe vera gel powder with over 18% acemannan
    – 700 mcg of folate as 5-MTHF (natural, coenzyme folate)
    – A smooth & delicious taste (even better than before!)

    Given all the upgrades I recently made to the formula, I certainly hope you will give it a try. I'm so happy with it, and I use it daily. Berries & Herbs hardly feels (or tastes!) like a nutritional supplement. But believe me, there are few superfoods anywhere that provide as much nutrition—or nutrient density!

    HIGHEST QUALITY INGREDIENTS – INCLUDING ORGANIC AND WILDCRAFTED

    To give you a better idea of the high-quality ingredients I put into Rejuvenate! Berries & Herbs, check out this complete list of ingredients:

    INGREDIENTS: REJUVENATE! BERRIES & HERBS contains: pea protein*, rice protein*, flax seed powder*, rice bran solubles, d-ribose, cranberry powder*, blueberry powder*, raspberry powder*, strawberry powder*, nutritional yeast, sunflower lecithin, inulin (from chicory root), broccoli sprouts powder*, mannitol, xylitol* (from hardwood), magnesium malate, VitaBerry® Plus† (from freeze dried wild blueberry, cranberry, raspberry, strawberry, prune, cherry, wild bilberry, whole grape powders, resveratrol, and quercetin), l-lysine hydrochloride, mixed berry flavoring* (on gum acacia), vanilla flavoring* (on gum acacia), RNA (from yeast), magnesium ascorbate, chlorella growth factor (CGF), burdock root powder*, astragalus powder*, turmeric root powder*, ginger root powder*, digestive multienzyme complex, choline bitartrate, malic acid, dulse*, kelp*, aloe vera* (BiAloe® concentrate), n-acetyl-l-cysteine, rutin, milk thistle extract, green tea extract, licorice root powder*, dandelion root powder*, rhodolia extract, inositol, biotin, stevia leaf extract, alpha lipoic acid, d-alpha tocopheryl succinate, niacinamide (Vit. B3), whole grape extract, high-gamma mixed tocopherols, phylloquinone (Vit. K1), immune assist mushroom extract, pantothenic acid, resveratrol, methylcobalamin (Vit. B12), pyridoxal-5’-phospate (Vit. B6), thiamin diphosphate (Vit. B1), riboflavin-5’-phosphate (Vit. B2), l-selenomethionone, cholecalciferol (Vit. D3), and calcium L-5-methyltetrahydrofolate.

    *Organic ingredient
    †VitaBerry Plus® is a registered trademark of VDF Futureceuticals, Inc.

    Rejuvenate berries and herbs nutrition facts table

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    Rejuvenate! Berries & Herbs is available from Health Products Distributors, Inc.:

    Try Rejuvenate! Berries & Herbs  (organic and wildcrafted berries & herbs)

    You may also like: Rejuvenate! PLUS (light, sweet green superfood)

    There are three Rejuvenate! superfoods. Which one is best for you? See our Rejuvenate!™ comparison page.

  • TASTY SMOOTHIE WITH REJUVENATE! BERRIES & HERBS

    Fred Liers PhD rejuvenate! berries & herbsToday I make a tasty smoothie with the new, improved REJUVENATE!™ BERRIES & HERBS superfood. In fact, Rejuvenate! Berries & Herbs is likely the most delicious among HPDI's Rejuvenate! superfoods, as it contains for types of real organic berries: Blueberries, Strawberries, Raspberries, and Cranberries. This uber-berry superfood was born for smoothies.

    Rejuvenate! Berries & Herbs is a uniquely healthy superfood that not only tastes amazingly good, but its high berry content gives it an ultra-high antioxidant value (ORAC) of 14,270 units per serving—an exceedingly high ORAC value compared to typical "superfood" formulas.

    Rejuvenate! Berries & Herbs provides 14.6 gm of organic protein (including organic pea and organic rice). It includes a potent cell-protective herbal complex (including green tea extract, ginger, turmeric, astragalus, burdock, dandelion, and rhodiola). In addition, it contains a built-in multivitamin sub-formula including coenzyme vitamins and other highly assimilable forms of important micronutrients.

    I especially love Rejuvenate! Berries & Herbs because my father Dr. Hank Liers formulated it to provide the most dietary nucleic acids per serving—390 mg (dietary RNA/DNA)—the most per serving in any Rejuvenate! superfood. Sources of dietary nucleic acids in Rejuvenate! Berries & Herbs include nutritional yeast, yeast extracts, and CGF (chlorella growth factor).

    Dietary nucleic acids are proven to provide significant benefits for health. Studies by pioneering nucleic acid researcher Benjamin S. Frank, MD, PhD indicate effects such as greater endurance, easier breathing (anti-anoxic effect), increased energy (ATP production), improved functional strength, warmer body temperature (e.g., cold resistance), and other effects. Dr. Frank asserts that dietary nucleic acids are essential nutrients, not unlike vitamins and minerals (Dietary Nucleic Acid Nutrition & Therapy).

    Considering all the benefits conferred by dietary nucleic acids, you really cannot go wrong by consuming more of them daily. And Rejuvenate! Berries & Herbs helps you do that by providing nearly 400 mg of dietary RNA/DNA per serving. That is a therapeutic dose which means you stand to gain all the benefits they confer. Depending on who you are and your health status, that could mean a lot in terms of helping you be healthier.

    To recap, Rejuvenate! Berries & Herbs uniquely offers: 1) High RNA (dietary nucleic acids), 2) High Antioxidant Levels, 3) Herbal Sub-Formula, 4) High Protein, 5) Built-in Multivitamin, and 6) SUPER TASTE—that is super delicious in your superfood smoothies.

    You just cannot get all these benefits in ANY other superfood, including other Rejuvenate! superfoods, each of which is formulated with a specific purpose. For example, Rejuvenate! PLUS is designed to provide significant levels of greens (think chlorella and spirulina), but lacks berries. Within its berry bailiwick, Rejuvenate! Berries & Herbs truly stands alone as one-of-a-kind.

    REJUVENATE! BERRIES & HERBS highlights:

    • Delicious Berry Flavor Bursts with Real Organic Berries (blueberries, strawberries, raspberries, cranberries)!
    • Powerful Organic and Wildcrafted Cell-Protective Herbs
    • High Antioxidant (ORAC) Value of 14,270 units per serving!
    • Contains Multiple Prebiotics Supporting Your Microbiome
    • Suitable for Vegetarians and Vegans & Gluten Free
    • Mixes Well with other Rejuvenate!™ superfoods (like Rejuvenate! PLUS and Rejuvenate! Original Greens) and smoothie ingredients.

    New, improved REJUVENATE! Berries & Herbs features (per serving):
    • 14.6 g protein
    • Very little sugar (1.2 g total)
    • 7.0 g more fiber (13 g total)
    • 100 mg of organic BiAloe® aloe vera gel powder with over 18% acemannan
    • 700 mcg of folate as 5-MTHF
    • Smooth texture & delicious taste!

    There you have it. If you're anything like me—and you love the taste of real, organic berries—consider Rejuvenate! Berries & Herbs to be your greatest ally when it comes it to tasty and healthy superfood nutrition. Make yourself a Berries & Herbs smoothie, and start creating health naturally today! ~

    REJUVENATE! BERRIES & HERBS DETAILS

    INGREDIENTS: REJUVENATE! BERRIES & HERBS contains: pea protein*, rice protein*, flax seed powder*, rice bran solubles, d-ribose, cranberry powder*, blueberry powder*, raspberry powder*, strawberry powder*, nutritional yeast, sunflower lecithin, inulin (from chicory root), broccoli sprouts powder*, mannitol, xylitol* (from hardwood), magnesium malate, VitaBerry® Plus† (from freeze dried wild blueberry, cranberry, raspberry, strawberry, prune, cherry, wild bilberry, whole grape powders, resveratrol, and quercetin), l-lysine hydrochloride, mixed berry flavoring* (on gum acacia), vanilla flavoring* (on gum acacia), RNA (from yeast), magnesium ascorbate, chlorella growth factor (CGF), burdock root powder*, astragalus powder*, turmeric root powder*, ginger root powder*, digestive multienzyme complex, choline bitartrate, malic acid, dulse*, kelp*, aloe vera* (BiAloe® concentrate), n-acetyl-l-cysteine, rutin, milk thistle extract, green tea extract, licorice root powder*, dandelion root powder*, rhodolia extract, inositol, biotin, stevia leaf extract, alpha lipoic acid, d-alpha tocopheryl succinate, niacinamide (Vit. B3), whole grape extract, high-gamma mixed tocopherols, phylloquinone (Vit. K1), immune assist mushroom extract, pantothenic acid, resveratrol, methylcobalamin (Vit. B12), pyridoxal-5’-phospate (Vit. B6), thiamin diphosphate (Vit. B1), riboflavin-5’-phosphate (Vit. B2), l-selenomethionone, cholecalciferol (Vit. D3), and calcium L-5-methyltetrahydrofolate.

    *Organic ingredient  †VitaBerry Plus® is a registered trademark of VDF Futureceuticals, Inc.

    rejuvenate berries & herbs nutrition facts table

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    RESOURCES:

    Discover Rejuvenate! Berries & Herbs  (Product Page)

    You may also like: Rejuvenate! PLUS (Product Page)

    Did you know there are 3 different Rejuvenate! superfoods? Which one is best for you? See our Rejuvenate! superfood comparison page.

  • WHAT YOU NEED TO KNOW ABOUT VITAMIN B12

    Dr. Hank Liers, PhD vitamin B12 B-12 cobalamin methylcobalaminI previously wrote METHYLATION CYCLE, GENETICS, B VITAMINS in which I considered in-depth how the Methylation Cycle functions, how genetics affect metabolic pathways, and how B vitamins (including vitamin B12, folate, vitamin B6, and vitamin B2) are used in Methylation Cycle pathways. In today's article, I take an in-depth view of what you need to know about vitamin B12, including the effects of not having sufficient amounts of Vitamin B12 in the body.

    Vitamin B12 is one of eight B vitamins. It is the largest and most structurally complicated vitamin. It consists of a class of chemically related compounds (vitamers), all of which show physiological activity. It contains the biochemically rare element cobalt positioned in the center of a chemical ring structure.

    vitamin B12 Vitamin B12 contains the biochemically rare element cobalt positioned in the center of a chemical ring structure.

    Vitamin B12 (also called cobalamin) is a water-soluble vitamin that is involved in the metabolism of every cell of the human body. It is a cofactor in DNA synthesis, and in both fatty acid and amino acid metabolism. It is particularly important in the normal functioning of the nervous system via its role in the synthesis of myelin and in the maturation of developing red blood cells in the bone marrow.

    YOUR NEED FOR VITAMIN B12

    Vitamin B12 deficiency is thought to be one of the leading nutritional deficiencies in the world. An extensive 2004 study showed that deficiency is a major health concern in many parts of the world, including the North America, Central and South America, India, and certain areas in Africa. It is estimated that 40 percent of people may have low levels of vitamin B12.

    Vitamin B12 affects your mood, energy level, memory, nervous system, heart, skin, hair, digestion and more. It is a key nutrient regarding adrenal fatigue and multiple metabolic functions including enzyme production, DNA synthesis, and hormonal balance.

    Because of vitamin B12's extensive roles within the body, a vitamin deficiency can show up in many different symptoms, such as chronic fatigue, mood disorders such as depression, chronic stress, and low energy.

    SOURCES OF VITAMIN B12

    The only organisms to produce vitamin B12 are certain bacteria and archaea. Some of these bacteria are found in the soil around the grasses that ruminants eat. They are taken into the animal, proliferate, form part of their gut flora, and continue to produce vitamin B12.

    Products of animal origin such as beef (especially liver), chicken, pork, eggs, dairy, clams, and fish constitute the primary food source of vitamin B12. Older individuals and vegans are advised to use vitamin B12 fortified foods and supplements to meet their needs.

    vitamin B12 salmon Salmon is a good source of Vitamin B12

    Commercially, Vitamin B12 is prepared by bacterial fermentation. Fermentation by a variety of microorganisms yields a mixture of methylcobalamin, hydroxocobalamin, and adenosylcobalamin. Since multiple species of propionibacterium produce no exotoxins or endotoxins and have been granted GRAS status (generally regarded as safe) by the United States Food and Drug Administration, they are the preferred bacterial fermentation organisms for vitamin B12 production.

    Methylcobalamin and 5-deoxyadenosylcobalamin are the forms of vitamin B12 used in the human body (called coenzyme forms). The form of cobalamin used in many some nutritional supplements and fortified foods, cyanocobalamin, is readily converted to 5-deoxyadenosylcobalamin and methylcobalamin in the body.

    Hydroxocobalamin is the direct precursor of methylcobalamin and 5-deoxyadenosylcobalamin. In mammals, cobalamin is a cofactor for only two enzymes, methionine synthase (MS) and L-methylmalonyl-coenzyme A mutase (MUT).

    Unlike most other vitamins, B12 is stored in substantial amounts, mainly in the liver, until it is needed by the body. If a person stops consuming the vitamin, the body’s stores of this vitamin usually take about 3 to 5 years to exhaust. Vitamin B12 is primarily stored in the liver as 5-deoxyadenosylcobalamin, but is easily converted to methylcobalamin.

    ABSORPTION OF VITAMIN B12

    Vitamin B12, bound to protein in food, is released by the activity of hydrochloric acid and gastric protease in the stomach. Intestinal absorption of vitamin B12 requires successively three different protein molecules: Haptocorrin, Intrinsic Factor and Transcobalamin II. If there are deficiencies in any of these factors absorption of Vitamin B12 can be seriously decreased.

    When vitamin B12 is added to fortified foods and dietary supplements, it is already in free form and, thus, does not require the separation from food protein step. Free vitamin B12 then combines with intrinsic factor, a glycoprotein secreted by the stomach’s parietal cells, and the resulting complex undergoes absorption within the distal ileum by receptor-mediated endocytosis.

    Approximately 56% of a 1 mcg oral dose of vitamin B12 is absorbed, but absorption decreases drastically when the capacity of intrinsic factor is exceeded (at 1–2 mcg of vitamin B12).

    Vitamin B12 – 5 mg methylcobalamin sublingual lozenge Vitamin B12 – 5 mg Methylcobalamin sublingual tablet.

    VITAMIN B12 DEFICIENCY

    Vitamin B12 deficiency can be difficult to detect, especially since the symptoms of a vitamin B12 deficiency can be similar to many common symptoms, such as feeling tired or unfocused, experienced by people for a variety of reasons.

    Vitamin B12 deficiency is commonly associated with chronic stomach inflammation, which may contribute to an autoimmune vitamin B12 malabsorption syndrome called pernicious anemia and to a food-bound vitamin B12 malabsorption syndrome. Poor absorption of vitamin may be related to coeliac disease. Impairment of vitamin B12 absorption can cause megaloblastic anemia and neurologic disorders in deficient subjects. In some cases, permanent damage can be caused to the body when B12 amounts are deficient.

    It is noteworthy that normal function of the digestive system required for food-bound vitamin B12 absorption is commonly impaired in individuals over 60 years of age, placing them at risk for vitamin B12 deficiency.

    A diagnosis of vitamin B12 deficiency is typically based on the measurement of serum vitamin B12 levels within the blood. However, studies show that about 50 percent of patients with diseases related to vitamin B12 deficiency have normal B12 levels when tested. This can cause individuals to ignore taking in adequate levels of vitamin B12 with potential serious consequences.

    FUNCTIONS AND ISSUES ASSOCIATED WITH VITAMIN B12 STATUS IN THE BODY

    • Vitamin B12 or cobalamin plays essential roles in folate metabolism and in the synthesis of the citric acid cycle intermediate, succinyl-CoA.

     

    • Vitamin B12 deficiency is commonly associated with chronic stomach inflammation, which may contribute to an autoimmune vitamin B12 malabsorption syndrome called pernicious anemia and to a food-bound vitamin B12 malabsorption syndrome. Impairment of vitamin B12 absorption can cause megaloblastic anemia and neurologic disorders in deficient subjects.

     

    • Normal function of the digestive system required for food-bound vitamin B12 absorption is commonly impaired in individuals over 60 years of age, placing them at risk for vitamin B12 deficiency.

     

    • Vitamin B12 and folate are important for homocysteine metabolism. Elevated homocysteine levels in blood are a risk factor for cardiovascular disease (CVD). B vitamin supplementation has been proven effective to control homocysteine levels.

     

    • The preservation of DNA integrity is dependent on folate and vitamin B12 availability. Poor vitamin B12 status has been linked to increased risk of breast cancer in some, but not all, observational studies.

     

    • Low maternal vitamin B12 status has been associated with an increased risk of neural tube defects (NTD), but it is not known whether vitamin B12 supplementation could help reduce the risk of NTD.

     

    • Vitamin B12 is essential for the preservation of the myelin sheath around neurons and for the synthesis of neurotransmitters. A severe vitamin B12 deficiency may damage nerves, causing tingling or loss of sensation in the hands and feet, muscle weakness, loss of reflexes, difficulty walking, confusion, and dementia.

     

    • While hyperhomocysteinemia may increase the risk of cognitive impairment, it is not clear whether vitamin B12 deficiency contributes to the risk of dementia in the elderly. Although B-vitamin supplementation lowers homocysteine levels in older subjects, the long-term benefit is not yet known.

     

    • Both depression and osteoporosis have been linked to diminished vitamin B12 status and high homocysteine levels.

     

    • The long-term use of certain medications, such as inhibitors of stomach acid secretion, can adversely affect vitamin B12 absorption.

     

    • Vitamin B12 is required for proper red blood cell formation, neurological function, and DNA synthesis.

     

    MORE DETAILS ASSOCIATED WITH VITAMIN B12 STATUS IN THE BODY

    1. Vitamin B12 is required for proper red blood cell formation, neurological function, and DNA synthesis. Vitamin B12 as methylcobalamin functions as a cofactor for methionine synthase. Methionine synthase (MS) catalyzes the conversion of homocysteine to methionine. Methionine along with ATP is required for the formation of S-adenosylmethionine (SAMe), a universal methyl donor for almost 100 different substrates, including DNA, RNA, hormones, proteins, and lipids.
    2. Vitamin B12 as 5-deoxyadenosylcobalamin functions as a cofactor along with L-methylmalonyl-CoA mutase (MUT) to convert L-methylmalonyl-CoA to succinyl-CoA in the degradation of propionate, an essential biochemical reaction in fat and protein metabolism. Succinyl-CoA is also required for hemoglobin synthesis.
    Metabolic Pathway

     

    3. Vitamin B12, bound to protein in food, is released by the activity of hydrochloric acid and gastric protease in the stomach. When synthetic vitamin B12 is added to fortified foods and dietary supplements, it is already in free form and, thus, does not require this separation step. Free vitamin B12 then combines with intrinsic factor, a glycoprotein secreted by the stomach’s parietal cells, and the resulting complex undergoes absorption within the distal ileum by receptor-mediated endocytosis. Approximately 56% of a 1 mcg oral dose of vitamin B12 is absorbed, but absorption decreases drastically when the capacity of intrinsic factor is exceeded (at 1–2 mcg of vitamin B12).

    4. Pernicious anemia is an autoimmune disease that affects the gastric mucosa and results in gastric atrophy. This leads to the destruction of parietal cells, achlorhydria, and failure to produce intrinsic factor, resulting in vitamin B12 malabsorption. If pernicious anemia is left untreated, it causes vitamin B12 deficiency, leading to megaloblastic anemia and neurological disorders, even in the presence of adequate dietary intake of vitamin B12.

    5. Vitamin B12 status is typically assessed via serum or plasma vitamin B12 levels. Values below approximately 170–250 pg/mL (120–180 picomol/L) for adults indicate a vitamin B12 deficiency. However, evidence suggests that serum vitamin B12 concentrations might not accurately reflect intracellular concentrations. An elevated serum homocysteine level (values >13 micromol/L) might also suggest a vitamin B12 deficiency. However, this indicator has poor specificity because it is influenced by other factors, such as low vitamin B6 or folate levels. Elevated methylmalonic acid levels (values >0.4 micromol/L) might be a more reliable indicator of vitamin B12 status because they indicate a metabolic change that is highly specific to vitamin B12 deficiency.

    6. Vitamin B12 deficiency is characterized by megaloblastic anemia, fatigue, weakness, constipation, loss of appetite, and weight loss. Neurological changes, such as numbness and tingling in the hands and feet, can also occur . Additional symptoms of vitamin B12 deficiency include difficulty maintaining balance, depression, confusion, dementia, poor memory, and soreness of the mouth or tongue. The neurological symptoms of vitamin B12 deficiency can occur without anemia, so early diagnosis and intervention is important to avoid irreversible damage. During infancy, signs of a vitamin B12 deficiency include failure to thrive, movement disorders, developmental delays, and megaloblastic anemia. Many of these symptoms are general and can result from a variety of medical conditions other than vitamin B12 deficiency.

    7. Typically, vitamin B12 deficiency is treated with vitamin B12 injections, since this method bypasses potential barriers to absorption. However, high doses of oral vitamin B12 can also be effective. The authors of a review of randomized controlled trials comparing oral with intramuscular vitamin B12 concluded that 2,000 mcg (I like 5,000 mcg) of oral vitamin B12 daily, followed by a decreased daily dose of 1,000 mcg and then 1,000 mcg weekly and finally, monthly might be as effective as intramuscular administration. Overall, an individual patient’s ability to absorb vitamin B12 is the most important factor in determining whether vitamin B12 should be administered orally or via injection. In most countries, the practice of using intramuscular vitamin B12 to treat vitamin B12 deficiency has remained unchanged.

    8. Large amounts of folate can mask the damaging effects of vitamin B12 deficiency by correcting the megaloblastic anemia caused by vitamin B12 deficiency without correcting the neurological damage that also occurs. Moreover, preliminary evidence suggests that high serum folate levels might not only mask vitamin B12 deficiency, but could also exacerbate the anemia and worsen the cognitive symptoms associated with vitamin B12 deficiency. Permanent nerve damage can occur if vitamin B12 deficiency is not treated. For these reasons, folate intake from fortified food and supplements should not exceed 1,000 mcg daily in healthy adults.

    Groups at Risk of Vitamin B12 Deficiency

    The main causes of vitamin B12 deficiency include vitamin B12 malabsorption from food, pernicious anemia, postsurgical malabsorption, and dietary deficiency. However, in many cases, the cause of vitamin B12 deficiency is unknown. The following groups are among those most likely to be vitamin B12 deficient.

    Older adults: Atrophic gastritis, a condition affecting 10%–30% of older adults, decreases secretion of hydrochloric acid in the stomach, resulting in decreased absorption of vitamin B12. Decreased hydrochloric acid levels might also increase the growth of normal intestinal bacteria that use vitamin B12, further reducing the amount of vitamin B12 available to the bodY.

    Individuals with atrophic gastritis are unable to absorb the vitamin B12 that is naturally present in food. Most, however, can absorb the synthetic vitamin B12 added to fortified foods and dietary supplements. As a result, the IOM recommends that adults older than 50 years obtain most of their vitamin B12 from vitamin supplements or fortified foods. However, some elderly patients with atrophic gastritis require doses much higher than the RDA to avoid subclinical deficiency.

    Individuals with pernicious anemia: Pernicious anemia, a condition that affects 1%–2% of older adults, is characterized by a lack of intrinsic factor. Individuals with pernicious anemia cannot properly absorb vitamin B12 in the gastrointestinal tract. Pernicious anemia is usually treated with intramuscular vitamin B12. However, approximately 1% of oral vitamin B12 can be absorbed passively in the absence of intrinsic factor, suggesting that high oral doses of vitamin B12 might also be an effective treatment.

    Individuals with gastrointestinal disorders: Individuals with stomach and small intestine disorders, such as celiac disease and Crohn’s disease, may be unable to absorb enough vitamin B12 from food to maintain healthy body stores. Subtly reduced cognitive function resulting from early vitamin B12 deficiency might be the only initial symptom of these intestinal disorders, followed by megaloblastic anemia and dementia.

    Individuals who have had gastrointestinal surgery: Surgical procedures in the gastrointestinal tract, such as weight loss surgery or surgery to remove all or part of the stomach, often result in a loss of cells that secrete hydrochloric acid and intrinsic factor. This reduces the amount of vitamin B12, particularly food-bound vitamin B12, that the body releases and absorbs. Surgical removal of the distal ileum also can result in the inability to absorb vitamin B12. Individuals undergoing these surgical procedures should be monitored preoperatively and postoperatively for several nutrient deficiencies, including vitamin B12 deficiency.

    Vegetarians: Strict vegetarians and vegans are at greater risk than lacto-ovo vegetarians and non-vegetarians of developing vitamin B12 deficiency because natural food sources of vitamin B12 are limited to animal foods. Fortified breakfast cereals and fortified nutritional yeasts are some of the only sources of vitamin B12 from plants and can be used as dietary sources of vitamin B12 for strict vegetarians and vegans. Fortified foods vary in formulation, so it is important to read the Nutrition Facts labels on food products to determine the types and amounts of added nutrients they contain.

    Pregnant and lactating women who follow strict vegetarian diets and their infants: Vitamin B12 crosses the placenta during pregnancy and is present in breast milk. Exclusively breastfed infants of women who consume no animal products may have very limited reserves of vitamin B12 and can develop vitamin B12 deficiency within months of birth. Undetected and untreated vitamin B12 deficiency in infants can result in severe and permanent neurological damage.

    The American Dietetic Association recommends supplemental vitamin B12 for vegans and lacto-ovo vegetarians during both pregnancy and lactation to ensure that enough vitamin B12 is transferred to the fetus and infant. Pregnant and lactating women who follow strict vegetarian or vegan diets should consult with a pediatrician regarding vitamin B12 supplements for their infants and children.

    Health Risks from Excessive Vitamin B12

    The IOM did not establish a UL for vitamin B12 because of its low potential for toxicity. In Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline, the IOM states that “no adverse effects have been associated with excess vitamin B12 intake from food and supplements in healthy individuals”.

    Findings from intervention trials support these conclusions. In the NORVIT and HOPE 2 trials, vitamin B12 supplementation (in combination with folic acid and vitamin B6) did not cause any serious adverse events when administered at doses of 0.4 mg for 40 months (NORVIT trial) and 1.0 mg for 5 years (HOPE 2 trial).

    Interactions with Medications

    Vitamin B12 has the potential to interact with certain medications. In addition, several types of medications might adversely affect vitamin B12 levels. A few examples are provided below. Individuals taking these and other medications on a regular basis should discuss their vitamin B12 status with their healthcare providers.

    Chloramphenicol: Chloramphenicol (Chloromycetin®) is a bacteriostatic antibiotic. Limited evidence from case reports indicates that chloramphenicol can interfere with the red blood cell response to supplemental vitamin B12 in some patients.

    Proton pump inhibitors: Proton pump inhibitors, such as omeprazole (Prilosec®) and lansoprazole (Prevacid®), are used to treat gastroesophageal reflux disease and peptic ulcer disease. These drugs can interfere with vitamin B12 absorption from food by slowing the release of gastric acid into the stomach. However, the evidence is conflicting on whether proton pump inhibitor use affects vitamin B12 status. As a precaution, healthcare providers should monitor vitamin B12 status in patients taking proton pump inhibitors for prolonged periods.

    H2 receptor antagonists: Histamine H2 receptor antagonists, used to treat peptic ulcer disease, include cimetidine (Tagamet®), famotidine (Pepcid®), and ranitidine (Zantac®). These medications can interfere with the absorption of vitamin B12 from food by slowing the release of hydrochloric acid into the stomach. Although H2 receptor antagonists have the potential to cause vitamin B12 deficiency, no evidence indicates that they promote vitamin B12 deficiency, even after long-term use. Clinically significant effects may be more likely in patients with inadequate vitamin B12 stores, especially those using H2 receptor antagonists continuously for more than 2 years.

    Metformin: Metformin, a hypoglycemic agent used to treat diabetes, might reduce the absorption of vitamin B12, possibly through alterations in intestinal mobility, increased bacterial overgrowth, or alterations in the calcium-dependent uptake by ileal cells of the vitamin B12-intrinsic factor complex. Small studies and case reports suggest that 10%–30% of patients who take metformin have reduced vitamin B12 absorption. In a randomized, placebo controlled trial in patients with type 2 diabetes, metformin treatment for 4.3 years significantly decreased vitamin B12 levels by 19% and raised the risk of vitamin B12 deficiency by 7.2% compared with placebo. Some studies suggest that supplemental calcium might help improve the vitamin B12 malabsorption caused by metformin, but not all researchers agree.

    REFERENCES

    FROM: https://academic.oup.com/ajcn/article/71/2/514/4729184
    Plasma vitamin B-12 concentrations relate to intake source in the Framingham Offspring Study

    The American Journal of Clinical Nutrition, Volume 71, Issue 2, 1 February 2000, Pages 514–522, https://doi.org/10.1093/ajcn/71.2.514

    ABSTRACT

    Background: Low vitamin B-12 status is prevalent among the elderly, but few studies have examined the association between vitamin B-12 status and intake.
    Objective: We hypothesized that vitamin B-12 concentrations vary according to intake source.
    Design: Plasma concentrations and dietary intakes were assessed cross-sectionally for 2999 subjects in the Framingham Offspring Study. The prevalence of vitamin B-12 concentrations <148, 185, and 258 pmol/L was examined by age group (26–49, 50–64, and 65–83 y), supplement use, and the following food intake sources: fortified breakfast cereal, dairy products, and meat.
    Results: Thirty-nine percent of subjects had plasma vitamin B-12 concentrations <258 pmol/L, 17% had concentrations <185 pmol/L, and 9% had concentrations <148 pmol/L, with little difference between age groups. Supplement users were significantly less likely than non-supplement-users to have concentrations <185 pmol/L (8% compared with 20%, respectively). Among non-supplement-users, there were significant differences between those who consumed fortified cereal >4 times/wk (12%) and those who consumed no fortified cereal (23%) and between those in the highest and those in the lowest tertile of dairy intake (13% compared with 24%, respectively), but no significant differences by meat tertile. Regression of plasma vitamin B-12 on log of intake, by source, yielded significant slopes for each contributor adjusted for the others. For the total group, b = 40.6 for vitamin B-12 from vitamin supplements. Among non-supplement-users, b = 56.4 for dairy products, 35.2 for cereal, and 16.7 for meat. Only the meat slope differed significantly from the others.
    Conclusions: In contrast with previous reports, plasma vitamin B-12 concentrations were associated with vitamin B-12 intake. Use of supplements, fortified cereal, and milk appears to protect against lower concentrations. Further research is needed to investigate possible differences in bioavailability.

     

    INTERNET REFERENCES

  • IRENA OSSOLA UPDATE – SUPPLEMENTS IN PROFESSIONAL CYCLING

    Irena Ossola pro cyclist nutritional supplementsHPDI's sponsored athlete Irena Ossola has been a bike tour leader in Italy this summer and fall. During that time, she scaled back her nutritional supplement regimen. This is partly because the summer and fall period is one of rest from high-intensity competitive bike training—and because her training for the new racing season has not yet begun. However, she recorded her observations regarding nutritional supplements. She concludes they are important whether or not she is actively training for races. – editor

    Irena Ossola supplements

    I have been working like a maniac and nonstop since I arrived in Italy for my bike touring job at the end of August. However, I am feeling good and recovering well and happy to move forward for next year in training. I am starting to really look forward to getting in some hard solid winter training now and especially being in Tucson will be amazing!! I can't wait to get back into my regular training regime. On another note, I've recorded some observations during my time in Italy about my nutrition and vitamins.

    Beginning August:

    "As I am now at the beginning of my touring/working season, I like to use this time as my sort of "off time" for supplements. Regarding vitamins and other nutritional supplements, I have found in the past that I have trouble staying on schedule and taking them while working. I feel that my nutrition is still adequate as I eat vegetables and meat and other necessary things for the amount of effort and activity I am putting my body through. Yet, I also know I will feel the difference without a constant flow of vitamins and supplements from Health Products Distributors, Inc."

    supplements Irena Ossola

    Beginning September:

    "Now that I am in my moment of break and I've been working constantly for about a month, I must stay that I have also not been taking vitamins for a couple weeks and I can definitely feel the difference. Especially in my diet when I am not eating as healthy (as I do when training) or being as consistent with consuming vegetables.

    I notice a lack of energy when I am working and lack of intensity on the bike when I'm riding. This is fine for now, and a good test for me as during this time I do not need a high-intensity effort while riding and it is a good test of my energy levels to see the contrast while I'm working compared to training.

    I will begin taking some supplements again regularly which I think will help and will also demonstrate the necessity to have a regular schedule of nutritional supplements even when my work and travel schedule is so busy."

    Irena Ossola cyclist supplements

    Beginning October:

    "Boy do I feel the difference! Since I have been regularly taking supplements again I can feel my energy going up and my willingness to push more and have more intensity on the bike. I feel the difference in my regular diet as well as I feel more motivated to eat healthy. This is a big contrast and difference I can see from the period when I was taking supplements to when I stopped and now again to taking them. This shows how big the influence of nutritional supplementation is for my body.

    I will continue taking my vitamins and being active while working and also eating a healthy diet to maintain my energy levels and physical ability. I am so busy while working that supplements are often hard to take while changing hotels or setting things up for the day. But if I have my vitamin bag and make sure to keep it somewhere easily accessible, then I am more willing to take them and can easily.

    It is great to be working so closely with an amazing company like Health Products Distributors, Inc. where I can do this sort of test to see the differences. It shows a huge difference in their products compared to just food and how they affect my body. I have been taking Mighty Multi-Vite!, Ultimate Protector, Essential Fats Plus E, and Myo-Mag.

    The supplements are amazing and I LOVE them and again I cannot wait to return to my competitive training this winter in Tucson." ~

    Irena Ossola supplements

    ==

    Editor's notes: Irena primarily takes HPDI Foundational Supplements which are the base or core of a nutritional supplement program. Foundational supplements include a high-potency multivitamin (Hank & Brian's Mighty Multi-Vite!™), vitamin C/antioxidant formulas (Ultimate Protector Nrf2 activator formula), essential fats (Essential Fats Plus E), and Rejuvenate! high-RNA superfoods (Rejuvenate! Original Greens, Rejuvenate! PLUS, and Rejuvenate! Berries & Herbs). She also takes other HPDI formulas like Myo-Mag (magnesium formula), pH Adjust alkalinizing formula, Warrior Mist (topical pain reliever), and other formulas depending on her needs.

    Read more about Irena cycling adventures on her blog: www.OssolaSport.com

  • EXCITING NEW TERRAFLORA SYNBIOTIC

    Terraflora Synbiotic

    Dr. Hank Liers, PhD Terraflora synbiotic probioticIt has finally arrived — the exciting new Terraflora™ synbiotic. A synbiotic is a combination of probiotics and supporting prebiotics. This advanced soil-based organisms formula fills the need for a superb probiotic/prebiotic in Health Products Distributors' arsenal of highly effective formulas. Terraflora is extremely supportive of your entire microbiome and gut-based immune system.

    If this sounds like an extremely useful formula—like it does to me—then keep reading about Terraflora™....

    ADVANCED GUT MICROBIOME SUPPORT

    INTRODUCING THE MICROBIOME

    For centuries, scientists have recognized a limited number of pathogenic bacteria for which antibiotic therapies have become the mainstream treatment. However, advanced DNA sequencing techniques coupled with data revealed from the Human Genome Project have made it possible to study a vast world of ‘germs’ – both pathogenic and beneficial – that dwarf our previous knowledge.

    While we inherit more than 22,000 genes from our parents, the bacteria that exist in and on our bodies contain at least eight million bacterial genes which amounts to 360 times more bacterial genes than human genes! The genetic material from bacteria that populate the human body is known as the human microbiome.

    Your microbiome is likely similar to that of your immediate family, as we naturally inherit our family’s microbiota. Through the course of our lives, we pick up other bacteria from food, water, and other parts of our environment. Scientists estimate we each carry 100 trillion bacteria in our intestinal tract alone!

    In this teeming landscape of bacteria, both you and the bacterial communities derive benefit. Many researchers use the term "mutually beneficial" when describing the evolving bacterial communities in our gut.

    THE BALANCE OF BACTERIA AND YOUR HEALTH

    In 2010, the Human Microbiome Project published an analysis of 178 genomes from bacteria that live in or on the human body. 10,000 different types of bacteria in the human body have been identified, including novel genes and proteins that serve functions in human health and disease. The vast numbers of bacteria discovered appear to provide benefit to the human body, not harm.

    Martin J. Blaser, chairman of the Department of Medicine and a professor of microbiology at the New York University (NYU) School of Medicine states: "Germs make us sick, but everyone focuses on the harm. It’s not that simple, because without most of these organisms we could never survive."

    As scientists map the human microbiome, they are beginning to understand the difference between normal and abnormal. Proper bacterial balance is vital to healthy immune function, providing appropriate protection against potential infections, playing a critical role in the digestion and absorption of food and nutrients, and even regulating mood. The interaction of multiple strains of bacteria is an essential element in health and wellbeing.

    The optimal balance of bacteria can be altered in many ways such as broad spectrum antibiotics that kill bacteria in the gut indiscriminately; prescription medications; disease-carrying bacteria, fungi, parasites, and yeasts; stress; lack of sleep; poor diet & lifestyle; geography and travel; and physical disconnection with nature.

    Researchers have shown that changes in gut bacteria even affect the brain and personality. For example, germ-free mice have been shown to be dramatically more anxious and hyperactive than their counterparts with a normal microbiome. These changes have also been associated with neurochemical changes in the mouse brain.

    Evidence supports the concept that microbiota balance can have a large impact on healthy metabolic processes. This delicate balance has a definite impact on nutrient acquisition and overall energy regulation.

    The impact of the gut microbiota is far reaching in the body. Continued investigation into the microbiome will yield powerful data, enabling the development of novel options to support healthy mood, metabolism, signaling molecules and much more.

    Terraflora synbiotic

    FEATURES OF TERRAFLORA

    Terraflora is a novel broad spectrum synbiotic formulated with a combination of spore form probiotics, and advanced, food-based, ancient prebiotics designed for robust support of gastrointestinal health.

    • Innovative gut microbiome support
    • Multi-strain, soil-based, beneficial bacteria to support microbial diversity in the GI tract
    • Proprietary blend of ancient, wild-harvested, certified organic prebiotic support
    • Terraflora's advanced formulation of beneficial strains and ancient prebiotics are designed to support the biodiversity reflected in ancestral diets
    • Shelf stable and requires no refrigeration
    • Highly bioavailable strains are protected by a natural seed-like structure, guarding against environmental factors and stomach acid
    • Strains effectively generate highly bioavailable riboflavin (vitamin B2) and antioxidant carotenoids, right at the sight of absorption
    • Induces anti-inflammatory effects to foster gut homeostasis
    • Supports immune health

    TERRAFLORA KEY BENEFITS

    VIABILITY – The natural seed-like structure encasing the probiotc bacteria in Terraflora™ protects them against degradation by stomach acid, so they reach their target destination — the lower GI tract — intact and alive.

    ADVANCED PREBIOTIC SUPPORT  Uniquely formulated with organic seaweeds (see reference 2 below), mushroom extracts (see reference 1 below), and humic acid (see reference 3 below). Terraflora's advanced prebiotic complex contains a diverse spectrum of naturally occurring food-based polyphenols and polysaccharides designed to support healthy intestinal flora.

    ANTIOXIDANT BENEFITS – Terraflora features Ribospore™ (Bacillus pumilus) and Bacillus megaterium EM144™, two novel probiotic strains shown in studies to produce highly bioavailable, gastric stable antioxidant carotenoids, right at the site of absorption.

    CONVENIENT — NO REFRIGERATION NECESSARY! – To ensure potency and viability, most probiotics require refrigeration and have a short shelf life. The inherently resilient bacteria in Terraflora are heat-stable, and require no refrigeration, uniting convenience and efficacy.

    WHY SOIL-BASED ORGANISMS?

    Through diet and lifestyle, our earliest ancestors were routinely exposed to spore-based bacteria found in healthy soils and our natural environment. In our modern and hyper-sanitized world, this primitive yet vital connection to nature has been all but lost.

    Soil-based organisms (SBOs) define a class of probiotic supplements based on a greater understanding of the incredible diversity of the human gut, coupled with a deeper appreciation for how humans and their commensal “helper” bacteria work together to produce a healthy system.

    Soil-based bacteria have a three-stage life cycle, with each stage triggered by nutrient availability: vegetative growth, sporulation, and germination. The sporulation phase is particularly relevant to its potential as a probiotic. The spore structure preserves the bacteria in a dormant phase and against any harm whether in any terrestrial environment or in the acidic environments of the stomach and upper intestines. When these probiotic microbiota are ingested, they travel all the way to the lower intestine where they come alive. Like a seed, warm temperatures, moisture, and nutrients stimulate the germination stage where bacteria emerges from dormancy. Soil-based probiotics are well-adapted to the environment of the gut, and have been shown to remain in the digestive tract where they can provide long term benefit.

    SBO probiotics are characterized by two traits that make them superior to other probiotics: 1) the spore phase enabling natural resistance to the harsh environment of the upper digestive tract and stomach, and 2) inherent environmental stability that does not require the addition of specialized coatings or preservatives to ensure a clinically relevant amount reaches the appropriate areas of the gut.

    Though SBO probiotics are based directly on symbiotic communities of bacteria found in natural soil environments, these organisms are not harvested directly from the earth to be packaged as a supplement. They are instead produced in a safe, monitored environment to ensure specificity of the strains.

    Why are soil-based probiotics so popular among clinicians, and what makes them so important?  The answer to this question lies in an understanding of the human gut microbiome.

    MULTI-STRAIN BACILLUS COMPLEX

    Bacteria are incredibly ubiquitous, highly adaptable ancient life forms that evolved relatively unchanged over nearly 4 billion years. Bacillus, in particular, is likely Earth’s most resilient bacteria―the oldest of which having been cultured and identified from the abdominal contents of extinct bees preserved in amber for 25 to 40 million years.

    Through diet and lifestyle, our earliest ancestors were routinely exposed to bacillus spores found in healthy soils and our natural environment. Yet we no longer have routine exposure to bacillus spores due to the hyper-sanitization of our post-industrial civilization. Terraflora’s unique probiotic + prebiotic bio-complex of commensal bacillus strains reconnect humans with their ancestral environment.

    Terraflora™ bridges the lost connection to our natural environment, with a sophisticated probiotic bio-complex of specific, commensal Bacillus strains. Selected for their unique characteristics, Bacillus are gram-positive bacteria that can exist in two forms. Under favorable conditions the bacteria grow in a vegetative form, but when starved of nutrients they differentiate into a dormant life form known as an “endospore” or simply a “spore”. These spores come alive when introduced to an ideal environment, like the human gut.

    Terraflora’s innovative DNA verified strain combination introduces Ribospore™ (Bacillus pumilus) and Bacillus megaterium EM144™, microorganisms scientifically proven to effectively produce highly bioavailable antioxidants and riboflavin, right at the site of absorption. Riboflavin is an essential nutrient for maintaining a healthy digestive tract.

    In addition to our proprietary new RibosporeTM (Bacillus pumilus) and Bacillus Megaterium EM144TM—Bacillus subtilis, Bacillus clausii, and Bacillus coagulans complete Terraflora’s multi-strain probiotic bio-complex.

    ADVANCED PREBIOTIC BIO-COMPLEX

    Terraflora™ contains a prebiotic blend of certified organic, wild-harvested seaweeds, mushroom extracts, and humic acid. These ancient, food-based prebiotics support commensal microbiota with a diverse spectrum of naturally-occurring polyphenols and polysaccharides designed to strengthen healthy intestinal flora. This bio-complex includes:

    LARCH ARABINOGALACTAN: A solvent-free water extract that retains all bioactive polyphenolic flavonoids present in Larch, including taxifolin and quercetin. Larch arabinogalactan is a densely branched, non-starch polysaccharide consisting of galactose and arabinose molecules. It has been shown to increase production of critical short-chain fatty acids (SCFAs) such as butyrate in the gut. Butyrate is the principle fuel for intestinal cells and supports healthy tight junctions in the gut lining. In addition, Larch arabinogalactan enhances beneficial gut flora and increases levels of beneficial intestinal anaerobes, particularly Bifidobacterium longum.

    FUCUS VESICULOSUS (BLADDERWRACK) & UNDARIA PINATIFIDA (WAKAME) EXTRACTS: These are certified organic solvent-free water extracts that are wild-harvested from clean ocean waters of Patagonia and Nova Scotia. They are rich in marine polyphenols and complex, sulfated, fucose-rich polysaccharides called fucoidans. Fucoidans are found in edible brown seaweeds and are shown to have multiple bioactivities including the support of healthy inflammation response in the GI tract. In vitro studies show that fucoidan effectively inhibits adhesion of pathogenic bacteria Helicobacter pylori and Escherichia coli to human cells. Furthermore, they increase the abundance of beneficial bacteria and significantly decrease inflammatory response and antigen load of the gut microbiota. In addition, they may also help maintain levels of beneficial bacteria in the gut during antibiotic use and are also known to increases the integrity of tight junctions in the gut lining.

    NORDIC CHAGA EXTRACT: This ingredient is a certified organic hot-water extract obtained exclusively from the mushroom fruiting body. It is sustainably wild-harvested in the Arctic (Finnish Lapland forest) and contains a diverse spectrum of polysaccharides and polyphenols. This extract has been shown to help protect against acute colonic inflammation and shown to decrease the Firmicutes-to-Bacteroidetes bacterial ratios. Decreased Firmicutes-to-Bacteroidetes ratios are significantly associated with lower body mass index (BMI).

    RED REISHI EXTRACT: A certified organic extract obtained by traditional hot-water extraction methods exclusively from the mushroom fruiting body. It contains a diverse spectrum of polysaccharides and polyphenols that have been shown to increase microbiota richness and regulate intestinal barrier function. It is known to support the health of the gut lumen. Furthermore, is has been shown to decrease Firmicutes-to-Bacteroidetes ratios and endotoxin-bearing Proteobacteria levels.

    HUMIC ACID: The humic acid in Terraflora™ is water extracted from ancient freshwater humate deposits. It has been shown to significantly increase the overall concentration of colonic microbiota.

    TERRAFLORA INGREDIENTS

    Probiotic Bio-Complex: 1 Billion Viable Cells per serving
    Ribosporea  (Bacillus pumilus)
    Bacillus megaterium EM144a
    Bacillus subtilis
    Bacillus clausii
    Bacillus coagulans

    
Prebiotic Bio-Complex: 850 mg per serving
    Larch Arabinogalactan (Larix spp.), Reishi (Ganoderma lucidum) Extract (fruiting body), Wild-Harvested Chaga (Inonotus obliquus) Extract (fruiting body), Wild-Harvested Nova Scotian Bladderwrack (Fucus vesiculosus) Extract (thallus), Wild-Harvested Patagonian Wakame (Undaria pinnatifida) Extract (sporophyll), Humic Acids.

    Other Ingredients: Plant cellulose (veggie capsule)

    Contains NO: dairy, wheat, yeast, gluten, corn, sugar, soy, shellfish, tree nuts, or GMOs. Made without stearates, fillers, binders, flow agents, or additives of any kind.

    DIRECTIONS

    Serving Size: Two Veggie Capsules            Servings Per Container: 30

    Suggested Use: Take 1–2 capsules per day with or without food, or as recommended by your health care professional.

    If you are pregnant, nursing, or have a medical condition, consult your healthcare practitioner before use.

    REFERENCES

    1. Article regarding the use of mushroom extracts as prebiotics:

      A Critical Review on Health Promoting Benefits of Edible Mushrooms through Gut Microbiota
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618583/

      Abstract
      Mushrooms have long been used for medicinal and food purposes for over a thousand years, but a complete elucidation of the health-promoting properties of mushrooms through regulating gut microbiota has not yet been fully exploited. Mushrooms comprise a vast, and yet largely untapped, source of powerful new pharmaceutical substances. Mushrooms have been used in health care for treating simple and common diseases, like skin diseases and pandemic diseases like AIDS. This review is aimed at accumulating the health-promoting benefits of edible mushrooms through gut microbiota. Mushrooms are proven to possess anti-allergic, anti-cholesterol, anti-tumor, and anti-cancer properties. Mushrooms are rich in carbohydrates, like chitin, hemicellulose, β and α-glucans, mannans, xylans, and galactans, which make them the right choice for prebiotics. Mushrooms act as a prebiotics to stimulate the growth of gut microbiota, conferring health benefits to the host. In the present review, we have summarized the beneficial activities of various mushrooms on gut microbiota via the inhibition of exogenous pathogens and, thus, improving the host health.

      2. Article regarding the use of seaweeds as prebiotics:
      Prebiotics from Marine Macroalgae [seaweeds] for Human and Animal Health Applications
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920542/

      Abstract
      The marine environment is an untapped source of bioactive compounds. Specifically, marine macroalgae (seaweeds) are rich in polysaccharides that could potentially be exploited as prebiotic functional ingredients for both human and animal health applications. Prebiotics are non-digestible, selectively fermented compounds that stimulate the growth and/or activity of beneficial gut microbiota which, in turn, confer health benefits on the host. This review will introduce the concept and potential applications of prebiotics, followed by an outline of the chemistry of seaweed polysaccharides. Their potential for use as prebiotics for both humans and animals will be highlighted by reviewing data from both in vitro and in vivo studies conducted to date.

      3. Article regarding the use of humic acids as prebiotics:
      Impact of humic acids oun the colonic microbiome in healthy volunteers
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920542/

      Abstract
      AIM: To test the effects of humic acids on innate microbial communities of the colon.
      METHODS: We followed the effects of oral supplementation with humic acids (Activomin®) on concentrations and composition of colonic microbiome in 14 healthy volunteers for 45 d. 3 × 800 mg Activomin® were taken orally for 10 d followed by 3 × 400 mg for 35 d. Colonic microbiota were investigated using multicolor fluorescence in situ hybridization (FISH) of Carnoy fixated and paraffin embedded stool cylinders. Two stool samples were collected a week prior to therapy and one stool sample on days 10, 31 and 45. Forty-one FISH probes representing different bacterial groups were used.
      RESULTS: The sum concentration of colonic microbiota increased from 20% at day 10 to 30% by day 31 and remained stable until day 45 (32%) of humic acid supplementation (P < 0.001). The increase in the concentrations in each person was due to growth of preexisting groups. The individual microbial profile of the patients remained unchanged. Similarly, the bacterial diversity remained stable. Concentrations of 24 of the 35 substantial groups increased from 20% to 96%. Two bacterial groups detected with Bac303 (Bacteroides) and Myc657 (mycolic acid-containing Actinomycetes) FISH probes decreased (P > 0.05). The others remained unaffected. Bacterial groups with initially marginal concentrations (< 0.1 × 109/mL) demonstrated no response to humic acids. The concentrations of pioneer groups of Bifidobacteriaceae, Enterobacteriaceae and Clostridium difficile increased but the observed differences were statistically not significant.
      CONCLUSION: Humic acids have a profound effect on healthy colonic microbiome and may be potentially interesting substances for the development of drugs that control the innate colonic microbiome.

  • WARRIOR MIST TOPICAL FOR PAIN RELIEF

    Fred Liers PhD warrior mist topical pain relieverWarrior Mist™ is the most effective formula for pain relief offered by HPDI. Warrior Mist is an all-natural, fast-acting, topical pain reliever that is effective for many types of pain. I should know. I have used it nearly every day—for years!

    Types of pain Warrior Mist is known to stop, reduce, or soothe include: back pain (including sciatica), knee pain, carpal tunnel syndrome, headaches (including migraines), neck pain and tension, stiff and painful (or pulled) muscles, plantar fascitis, arthritis, sports injuries, old injuries, sprains and strains, bruises (including deep bruises), shin splints, tennis elbow, nerve pain, and post surgery pain.

    Practicing aikido for years, I have a frequent need for the rapid effects of Warrior Mist. Having used it for regularly for a long time, I appreciate how quickly it relieves pain like joint pain or sprains. It also works spectacularly for bruises, cuts, abrasions, burns, bug bites, and many other applications.

    TESTIMONIAL: "This really works. I had tried several other products, including prescription medications, and little success. There was a noticeable difference after my first use of the product." – Amazon customer

    Warrior Mist comes in a convenient one-ounce spray bottle. I shake the bottle and then add a few pumps—or as many as I need—to my non-pumping hand and rub onto the affected area. You can also spray it directly onto skin before rubbing it in with a clean hand. If you need more, you can always unscrew the cap and pour directly into your hand or onto skin, but I usually only reserve this action for times when I'm at the end of the bottle and I want to use all the Warrior Mist remaining in the bottle.

    The small bottle travels well, and I usually take it with me whenever I travel. I also keep a bottle ready in a small hiking kit that I carry with me on the trail. While I may not always need it, nevertheless it is there. I cannot count how often I used it when I've least expected to need it. Sprained ankles or swollen fingers heal a lot faster than you might expect, compared to not having Warrior Mist around. It even works well on things like mosquito bites—and helps repel them.

    Warrior Mist can be combined effectively with other natural topical products, especially Ancient Minerals Magnesium Oil (see video). I often mix a little Warrior Mist with Magnesium Oil in my palm. This mix gives me all the benefits of Warrior Mist with the added boost of extra magnesium chloride that speeds healing.

    Warrior Mist pain relief formula

    WARRIOR MIST BENEFITS

    Warrior Mist offers rapid pain relief and many other benefits:

    • RAPID, EFFECTIVE PAIN RELIEF – Formulated as a fast-acting pain reliever using only natural ingredients

    • LONG LASTING – pain relief last eight hours (or more) per use. This is a natural formula, so you will eventually need to re-apply it. But fewer applications means more time living life pain free.

    • SAFE – 100% natural formula. This means that unlike prescription drugs or many over-the-counter medicines, there are no harsh or dangerous side effects.

    • RAPID HEALING. Not only effectively relieves pain, but also supports rapid healing at the cellular level. It thereby supports healing at the sources of pain. i.e., helps with the underlying causes of pain.

    • REDUCES MUSCLE SORENESS AND TENSION. Another benefit of direct topical application of natural, yet powerful (mostly herbal) ingredients. While this has obvious benefits for athletes, it also helps weekend warriors, or anyone who has muscle soreness due to any reason!

    • INCREASES CIRCULATION. Increased circulation is a significant healthy benefit in itself, allowing better oxygenation of tissues, supporting healing, reducing stagnation of blood, and boosting processes of detoxification.

    • LESSENS INFLAMMATION. Inflamatory processes can be harmful to the body. Warrior Mist helps reduce inflammation naturally, and thereby lessens free-radical damage from it, for example. This significantly supports your healing process.

    • TISSUE REPAIR. When the ingredients in Warrior Mist penetrate tissues, then those tissues can begin the process of healing and repair, and do it faster!

    • HEALS SKIN IRRITATIONS. A major added benefit is the healing of "minor" skin irritations, cuts, abrasions, etc. This is because the ingredients in Warrior Mist™ do double duty as superb nutrients for the skin.

    • SCAR REDUCTION. Warrior Mist™ can soften scar tissues and stimulate the kind of deep healing that results in smaller scars and improved appearance of scars.

    TESTIMONIAL: "Warrior Mist is the only product that I have found which truly relieves the osteoarthritis pain in my knee!! I am amazed by the speed and effectiveness of Warrior Mist. As an older person who has planned and worked to be able to complete my life in my own home, Warrior Mist contributes enormously to my ability to do that! Thank you for this excellent product!" – Amazon customer

     

    WHY IS WARRIOR MIST EFFECTIVE?

    Warrior Mist™ is a revolutionary skin, muscle, and joint support formula that uses DMSO, olive oil, coconut oil, and water as base (or carrier) ingredients that transdermally transport the other ingredients directly to the site of the problem where they work together harmoniously and effectively.

    Functional ingredients carried to the site of pain include: peppermint oil (the primary source of menthol in the product), magnesium chloride, MSM, lemon oil, and lavender oil. Each of the functional ingredients (and their amounts) were carefully selected for their ability to stop pain, to help the body overcome the causes of pain, to promote healing at the local level, or to work synergistically with the other ingredients. Warrior Mist is 100% all-natural and totally safe!

    As a topical analgesic, Warrior Mist conforms to the proposed rules set forth in FDA Monograph 348. The label used on the current Warrior Mist (1 oz spray bottle) meets the requirements set forth in this monograph. Even though there are a number of ingredients in Warrior Mist that can potentially provide temporary pain relief, the FDA monograph only recognizes the ingredient menthol, the major ingredient in peppermint oil, as an allowable active ingredient. According to the monograph, we can only mention menthol as the active ingredient and all other ingredients must be labelled as inactive ingredients.

    The truth is that all the ingredients (functional and base/carrier ingredients) add up to a synergistic formula that rapidly relieves pain in a single, easy-to-apply topical product. What more could you ask for?

    WHAT INGREDIENTS DOES WARRIOR MIST CONTAIN?

    COMPOSITION / INGREDIENTS: DMSO (99.999% pure), peppermint oil, organic olive oil, distilled water, MSM, magnesium chloride, lemon oil, lavender oil, and organic coconut oil.

    DMSO
    Dimethyl sulfoxide (DMSO), a by-product of the wood industry, has been in use as a commercial solvent since 1953. Furthermore, in 125 countries throughout the world doctors prescribe it for a variety of issues, including inflammation. DMSO has been used widely as a carrier in topical analgesic formulas. Laboratory studies have shown that DMSO is able to block peripheral nerve C fibers.

    Burns, cuts, and sprains have been treated with DMSO. Relief is reported to be almost immediate, lasting up to 6 hours. DMSO reduces inflammation by several mechanisms. It is an antioxidant, a scavenger of the free radicals that gather at the site of injury. Studies have shown DMSO to be one of the safest ingredients known with a toxicity similar to that of water.

    DMSO has long been used to promote healing both in animals and humans. Those who have used it for minor cuts and burns report that recovery is speedy. Several studies have documented DMSO use with soft tissue damage, local tissue death, skin ulcers, and burns. Applied topically and repeatedly, DMSO flattens the raised, nodular, lobed liner mass of scar tissue in keloids and acne.

    MSM
    MSM is a naturally occurring nutrient found in normal human diets. In the body DMSO and MSM, which form each other, are indistinguishable in their biochemical effects. They reach a equilibrium distribution between them that is dependent on the local body chemistry, and is independent of which one you start with. The metabolic enhancement mechanism of MSM and DMSO is that of an exceptionally effective oxygen transport system. This system is made particularly effective by the feature that both DMSO and MSM are highly soluble in both oil and water.

    MSM makes cell walls permeable, allowing water and nutrients to freely flow into cells and allowing wastes and toxins to properly flow out. The body uses MSM along with Vitamin C to create new healthy cells, and MSM provides the flexible bond between the cells. Without proper levels of MSM, our bodies are unable to build healthy cells, and this leads to problems such as lost flexibility, scar tissue, wrinkles, varicose veins, hardened arteries, damaged lung tissues, dry cracking skin, digestive disorders, joint problems, and inability to defend against allergic reactions to food, animals and plants.

    The applications of MSM include pain control (analgesic), inflammation control, dilation of blood vessels, increased blood flow, reduced muscle spasm, altering the crosslinking process in collagen (e.g., reducing scar tissue,) anti-parasitic effects (particularly against Giardia), and immune normalizing effects. MSM has a unique ability to pass through cellular membranes (including skin).

    Peppermint Oil
    The primary constituent of peppermint oil is menthol, which causes a physical reaction when inhaled or applied to the skin. Menthol produces an immediate and pronounced sensation of coolness that effects the body quite noticeably, and creates a "warming effect" as blood flows into the area of application.

    Peppermint oil can be used externally for providing relief from pain. Peppermint oil increases your immunity. It also improves blood circulation. Additional of the uses of peppermint oil include:acne, asthma, colds, cramps, dermatitis, exhaustion, influenza, headache, insect bites, mental fatigue, migraine, nausea, nerve pain, neuralgia, poor circulation, and respiratory disorders.

    Lavender Oil
    Lavender oil helps in treating migraines, headaches, anxiety, depression, nervous tension and emotional stress. The refreshing aroma removes nervous exhaustion and restlessness and increases mental activity. Because it induces sleep, it is often recommended for insomnia. Lavender oil is also an excellent remedy for various types of pains including those caused by sore muscles, tense muscles, muscular aches, rheumatism, sprains, backache,and lumbago. A regular massage with lavender oil can provide relief from pain in the joints.

    Lavender oil is also good for improving blood circulation in the body. The health benefits of lavender oil for the skin can be attributed to its antiseptic and antifungal properties. It is used to treat various skin conditions, including acne, wrinkles, psoriasis, and other inflammatory conditions. It heals wounds, cuts, burns, and sunburns rapidly because it aids in the formation of scar tissues. It is also effective against insect bites. The oil also repels mosquitoes and moths.

    Lemon Oil
    Lemon oil is powerfully astringent and antiseptic. Lemon oil is detoxifying and is therefore good for blemishes associated with oily skin. Lemon oil is a powerful antioxidant and is a tonic for supporting the nervous and sympathetic nervous system. It's been long known that lemon oil is anti-infective, antibacterial (especially with spores), and antiviral. It can function as a disinfectant and exerts vitamin P-like action for improving microcirculation, promotes white blood cell formation, and improves immune function. It has also been widely used in skin care to cleanse skin and reduce wrinkles.

    Magnesium Chloride
    Magnesium chloride applied to the skin is an effective means for increasing magnesium levels in the body, and is particularly useful for relieving sore muscles and joints, and reducing pain related to functional magnesium deficiency. It is also proven for use in helping to calm “nerves” and reduce systemic bodily stress. Because the magnesium targets muscle tissues, it is thereby especially useful for replenishing depleted soft tissues and helping restore proper function.

    Magnesium is necessary for the production of energy in the body. When the body receives adequate amounts of magnesium, it can produce the levels of energy required to sustain the body and enable it to thrive. Magnesium chloride is proven for use in a variety of general applications, including bruises, cramps, muscle tension, and migraine headaches.

    Olive Oil
    Used as a base and mixed with other essential oils, olive oil makes a wonderful oil for skin health. In fact, it has been touted as one of the oldest healing and beauty techniques. A biblical reference from about 493 BCE documents the daily massage with olive oil and other oils as a part of the beauty regimen.

    Coconut Oil
    Coconut oil is a superb skin lotion because it both nourishes skin and is naturally anti-bacterial, antiviral, and antifungal due to its high content of medium chain triglycerides

    DIRECTIONS: Shake bottle before applying. Wash hands before and after use. Apply in a thin layer to a clean, dry, and lotion-free area needing support. Shave thick hair that may prevent absorption by the skin. Gently massage the area of application to assist absorption. Reapply as needed 3–4 times daily. Contains DMSO, a known solvent. Use on people or pets at your own discretion.

    USES: Warrior Mist™ is an all-natural skin, muscle, and joint support formula.

    WARNINGS: For external use only. May cause temporary (up to 45 minutes) skin irritation, heating, or flushing upon use. Discontinue use if temporary skin conditions persist. Do not use on wounds or severely damaged skin. Do not bandage tightly. Avoid contact with eyes. Flush eyes with cool water if exposed. Do not use if allergic to any ingredients. Stop use and visit a health care professional if reason for use continues for more than one week. If swallowed get medical help or call a Poison Control Center. Consult a health care professional before use if pregnant.

    Warrior Mist topical pain formula

    CONCLUSION

    Warrior Mist topical formula is highly effective for pain relief. A major advantage is that it is a natural formula (available without a prescription) and can safely be re-applied whenever necessary. Another benefit is that it lacks the side effects common to prescription pain medications.

    Try Warrior Mist for yourself. If you're like me, you will want to keep a bottle or two ready for the aches and pains of daily life. Use it as often as you need it. Be a warrior!

    RESOURCES

    PRODUCTS

    Warrior Mist

    Ancient Minerals Magnesium Oil

    Ancient Minerals Magnesium Oil, Flakes, Gel, Lotion

    Warrior Health Products

    Creams, Salves, and Topical Formulas

     Topical Formulas

    BLOG ARTICLES

    Effective Pain Relief Strategies with Warrior Mist

    Warrior Mist: Creating an Amazing Pain Relief Formula

    Super Remedies for Stings and Bites

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