Health Products Distributors

Food

General discussion of food and food-related subjects
  • OMEGA-3 ESSENTIAL FATS REMAIN "ESSENTIAL" – A REBUTTAL FROM OMNS

    Fred Liers PhD omega-3 essential fats plus e EFA formulaOmega-3 essential fatty acids (EFA) are critically important for health. That is the reason we at HPDI include them in our foundational supplements system in the form of our Essential Fats Plus E formula. Essential Fats Plus E provides a balanced ratio of 4:1 omega-3 EPA to omega-6 GLA fatty acids proven to optimally support health.

    As important as Omega-3 fats are in good health, various studies conclude they are of little value. In order to help clarity the fallacies found in such studies, this month we re-print the recent article "Omega 3 Fatty Acids and Cardiovascular Disease" from the Orthomolecular News Service (OMNS).

    BACKGROUND

    Essential fats including Omega-3 and Omega-6 are so important to health that we consider them as foundational or "core" to basic nutrition as multivitamins, antioxidants/vitamin C formulas, and high-RNA superfoods, like Rejuvenate! Plus.

    Many of today's health problems relate to deficiencies in Omega-3 essential fatty acids rather than overabundance of it. It makes sense for everyone to supplement their diets with at least a minimum amount of essential fats. This is addition to consuming foods high in Omega-3 (and Omega-6) essential fats, including leafy greens, nuts, seeds, and seed oils. Also, small amounts of wild-caught fish from clean waters. Preferably these fish would come from low on the food chain, such as sardines, herring, or young mackerel, for example.

    In December 2107, my father Hank Liers, PhD, wrote "The Truth about Essential Fatty Acids." In his article, he delves into detail about why essential fatty acids are critical for health.

    The diagram below from Dr. Hank's article shows in detail the pathways for the production and use of fatty acids in the body. In the figure the metabolic pathways (running left to right) for four fatty acids types are shown (top - Omega-3, second - Omega-6, third - Omega-9, bottom - Omega-7). Notice that only the omega-3 and omega-6 oils are considered to be essential fatty acids because they cannot be made in the body. This means they must come from food.

    omega-3 fats omega-6 fats

    Furthermore, an additional diagram from Dr. Hank's article shown below provides details of the omega-6 and omega-3 pathways. Pathway specifics indicate key eicosanoids (series 1 prostaglandins [anti-inflammatory], series 2 prostaglandins [pro-inflammatory], and series 3 prostaglandins [anti-inflammatory]), oil sources, and important nutrient cofactors that are needed for the reactions to take place.

    omega-3 fats omega-6 fats

    In particular, Dr. Hank discusses how superior benefits to health result from a balanced 4:1 ratio between Omega-3 eicosapentanoic acid (EPA) fatty acids and Omega-6 gamma linoleic acid (GLA).

    Below we list some of the functions and benefits obtained when by diet or supplementation the correct ratios and amounts of essential fatty acids are consumed.

    • Regulate steroid production and hormone synthesis
    • Regulate pressure in the eyes, joints, and blood vessels
    • Regulate response to pain, inflammation, and swelling
    • Mediate Immune Response
    • Regulate bodily secretions and their viscosity
    • Dilate or constrict blood vessels
    • Regulate smooth muscle and autonomic reflexes
    • Are primary constituents of cellular membranes
    • Regulate the rate at which cells divide
    • Necessary for the transport of oxygen from the red blood cells to tissues
    • Necessary for proper kidney function and fluid balance
    • Prevent red blood cells from clumping together
    • Regulate nerve transmission

    Dr. Hank also discusses the fallacy of thinking that supplemental Omega-3 fats alone are sufficient to produce health. That is, despite the relative lack of Omega-3 essential fats and the prevalence of Omega-6 fats in modern diets, it is nevertheless the forms (EPA and GLA)—and the critical 4:1 ratio between them—that makes the difference in how they act synergistically for health. The result of Hank's scientific understanding of essential fatty acids has resulted in his formulation of a balanced EFA product, Essential Fats Plus E.

    Orthomolecular Medicine News Service Article "Omega 3 Fatty Acids and Cardiovascular Disease"

    Regarding the Orthomolecular Medicine News Service article "Omega 3 Fatty Acids and Cardiovascular Disease" (republished below) rebutting the "Cochrane Database of Systematic Reviews" which relies on so-called "Evidence Based Medicine" (EBM) to distort truth on Omega-3 essential fatty acids, the fact that Omega-3 fats are under such false attack represents a huge disservice to the public.

    While essential fatty acids may not generate profits for corporations—and in fact may lead to improved health outcomes that threaten the use of chemicals and drugs—essential fats nevertheless remain foundational for health.

    Above we have shown the important reasons Omega-3 fats and other essential fatty acids are scientifically termed "essential." And why people continue taking essential fats, and giving them to their families and children, for supporting health and well-being. Primary among these reasons is that you cannot be healthy without them. Hence, they are essential. Why believe anyone who says otherwise?

    The bottom line: Omega-3 essential fatty acids are critical for health. Supplementing the diet with them is a good idea for nearly everyone. This is especially true because typical diets are proven to be most deficient in Omega-3 among essential fats.

    Below we re-print in full the recent article "Omega 3 Fatty Acids and Cardiovascular Disease" from the Orthomolecular News Service (OMNS) for the benefit of our HPDI blog readers. ~

    ===

    FOR IMMEDIATE RELEASE
    Orthomolecular Medicine News Service, Aug 6, 2018

    Omega-3 Fatty Acids and Cardiovascular Disease

    Commentary by Damien Downing, MBBS, MSB and Robert G. Smith, PhD

    The Cochrane Database of Systematic Reviews has just updated its own review: Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease [1]. Here's our take on it.

    Michael Pollan, the brilliant food writer, reckoned you could sum up what to do about nutrition and diets in 7 words; "Eat food, not too much, mostly plants." That sums up both what's best for humans and what's best for the planet.

    We reckon you can sum up what's wrong with evidence-based medicine (EBM) in 10 words; "Evidence is a waste of data; systematic reviews are palimpsests." You can use that as a knife to quickly dissect this study.

    There are many things wrong with this review. Somebody's PR department has spun the review's "no clear evidence of benefit" into "evidence of no benefit" - absence of evidence becoming evidence of absence. And clearly the media were entirely happy to take that one and run with it.

    Systematic reviews are palimpsests

    What's a palimpsest? Back when things got written on vellum, an animal skin, not on paper, you didn't throw it away; you recycled it and wrote over the original. It was called a palimpsest.

    A systematic review gives an opportunity to write over the conclusions of a whole list of papers with your new version of the truth. You do that by the way that you select and exclude them.

    For instance there was a meta-analysis (that's a systematic review with more numbers) in 2005 that concluded that vitamin E supplements significantly increased the risk of death [2]. The way they did that was to rule out any study with less than 10 deaths - when fewer deaths was exactly the outcome they were supposed to be looking for.

    The reason they gave for doing that was "because we anticipated that many small trials did not collect mortality data." We're not buying it; they used it as a trick to enable them to get the negative result they wanted - to over-write the findings of a long list of original studies.

    And here we have authors doing the very same thing in this omega-3 study - and upping the ante slightly. Now the threshold is 50 deaths. Fewer than that and your study is ruled out of the final, supposedly least biased, analysis . . on the grounds that it's more biased.

    We don't know how they could keep a straight face while saying (our interpretation); "The studies with fewer deaths showed more benefit from omega-3s, so we excluded them." At least that's what happened back in 2004 when the first version of this came out.[3]

    But this is the 8th update (we think) and they no longer bother to tell you about what they included or excluded in detail, so we can only assume that if they had changed that exclusion they would have told us.

    The weird thing is that they are allowed to do it. Nutrition researcher Dr. Steve Hickey has shown that in systematic reviews there is generally control for bias in the included studies, but none for bias in the actual review and its authors.[4,5]

    They found not one example of adequate blinding among 100 Cochrane reviews (like this one); they could all be palimpsests. Do we know that they are fake? No, but it doesn't matter: what we do know is that we can't trust them. Nor can we trust this Cochrane review. Things haven't changed since 2004.

    Evidence is a waste of data

    Evidence is what lawyers and courts use to find someone Guilty or Not Guilty, and we all know how that can go wrong. It's a binary system: you're either one or the other. But at least if you're on trial all the evidence should be about you and whether you did the crime.

    In EBM the evidence is all about populations, not about individuals. When a doctor tells you "There's a 1 in 3 chance this treatment will work" he is required to base that on big studies, or even systematic reviews. You don't, and you can't, know what that means for you because very likely you don't fit the population profile.

    As Steve Hickey (again) said, the statistical fallacy underlying all this states that you have one testicle and one ovary - because that's the population average! The authors of this study update started off with about 2100 papers that looked relevant. They then excluded 90 per cent of them for various reasons - some of them good reasons, some not.

    A smarter way to work would be to data-mine them and look for useful information about sub-groups and sub-effects in all the papers. Is there a particular reason omega-3s might work for you and not for others? Perhaps you can't stand fish, or are allergic to them, and so are deficient in omega-3s.

    But the review system doesn't allow it, it insists on overall conclusions (about populations), and that's a colossal waste of data. It also confounds the overall finding of the review - it biases it in fact.

    Here's an example: while most subgroups that made it to the final analysis showed a small reduction in risk from taking omega-3s in one form or another (pills, food, whatever), those who got it from supplemented foods, which we understand means stuff like margarine with added omega-3, showed a 4.3-fold death risk increase!

    The problem here is that the effects of omega-3 fatty acids cannot be studied alone as if they were a drug. What counts are all the other components of the diet that affect a person's health.

    Processed foods and drinks that contain many unhealthy ingredients can't be made healthy by adding small doses of vitamins, minerals, and omega-3 fatty acids. In fact, many processed foods that contain small doses of vitamins and other essential nutrients are unhealthy because they contain large doses of sugar, salt, and harmful ingredients such as preservatives, dyes, and other non-food items.

    Why lipids are so important

    Part of the problem is that lipids are truly complicated, and not many people, patients, doctors or even scientists, understand them well. You need a good understanding of lipid metabolism to appreciate the difference in metabolism and impact between alpha-linolenic acid (ALA, in food such as oily fish) and extracted oils such as EPA and DHA that are only found at high levels in omega-3 supplements.

    At these levels they are effectively new to nature; nobody, indeed no mammal, was exposed to really high doses of DHA until we invented fish oil supplements [6]. Miss that fact and you miss the difference between having people eat fresh oily fish or just using omega-3 margarine!

    We know from a variety of studies that a diet containing generous portions of green leafy and colorful vegetables and fruits, moderate portions of eggs, fish, and meat, and supplements of adequate doses of essential nutrients (vitamins and minerals) is effective at lowering the risk for cardiovascular disease.

    Adequate doses of both omega-3 (in flax oil, walnuts, fish) and omega-6 (in seed oils such as canola, soybean, peanut) fatty acids are essential for health. Although essential, omega-6 fatty acids are thought to contribute to inflammation throughout the body whereas omega-3 fatty acids are anti-inflammatory.

    Omega-3 fatty acids are essential for most body organs including the brain but are found in lower levels than omega-6 fatty acids in most vegetables. Risk for cardiovascular disease can be lowered by adequate doses of vitamins C (3,000-10,000mg/d), D (2,000-10,000 IU/d), E (400-1,200 IU/d), and magnesium (300-600 mg/d) in addition to an excellent diet that includes an adequate dose of omega-3 fatty acids.[7]

    (Dr. Damien Downing is a specialist physician practicing in London, and President of the British Society for Ecological Medicine. Robert G. Smith is a physiologist and Research Associate Professor at the University of Pennsylvania Perelman School Of Medicine.)

     

    References:

    1. Abdelhamid, A, Brown TJ, Brainard JS, et al., (2018) Omega 3 fatty acids for the primary and secondary prevention of cardiovascular disease. Cochrane Database of Syst Rev. 7:CD003177. https://www.ncbi.nlm.nih.gov/pubmed/30019766
    http://cochranelibrary-wiley.com/doi/10.1002/14651858.CD003177.pub3/abstract

    2. Miller ER, Pastor-Barriuso R, Dalal D, et al., (2005) Review Meta-Analysis?: High-Dosage Vitamin E Supplementation May Increase. Annals of Internal Medicine, 142(1), pp.37-46. Available at: http://annals.org/article.aspx?articleid=718049.

    3. Hooper L, Thompson RL, Harrison RA, et al.. (2004) Omega 3 fatty acids for prevention and treatment of cardiovascular disease. Cochrane Database Syst Rev. (4):CD003177. http://cochranelibrary-wiley.com/doi/10.1002/14651858.CD003177.pub2/abstract

    4. Hickey S, Noriega LA. Implications and insights for human adaptive mechatronics from developments in algebraic probability theory, IEEE, UK Workshop on Human Adaptive Mechatronics (HAM), Staffs, 15-16 Jan 2009.

    5. Hickey S, Hickey A, Noriega LA, (2013) The failure of evidence-based medicine? Eur J Pers Centered Healthcare 1: 69-79. http://ubplj.org/index.php/ejpch/article/view/636

    6. Cortie CH, Else, PL, (2012) Dietary docosahexaenoic acid (22:6) incorporates into cardiolipin at the expense of linoleic acid (18:2): Analysis and potential implications. International Journal of Molecular Sciences, 13(11): 15447-15463. http://www.mdpi.com/1422-0067/13/11/15447

    7. Case HS (2017) Orthomolecular Nutrition for Everyone. Turner Publication Co., Nashville, TN. ISBN-13: 978-1681626574

    Nutritional Medicine is Orthomolecular Medicine

    Orthomolecular medicine uses safe, effective nutritional therapy to fight illness. For more information: http://www.orthomolecular.org

    Find a Doctor

    To locate an orthomolecular physician near you: http://orthomolecular.org/resources/omns/v06n09.shtml

    The peer-reviewed Orthomolecular Medicine News Service is a non-profit and non-commercial informational resource.

    Editorial Review Board:

    Ilyès Baghli, M.D. (Algeria)
    Ian Brighthope, M.D. (Australia)
    Prof. Gilbert Henri Crussol (Spain)
    Carolyn Dean, M.D., N.D. (USA)
    Damien Downing, M.D. (United Kingdom)
    Michael Ellis, M.D. (Australia)
    Martin P. Gallagher, M.D., D.C. (USA)
    Michael J. Gonzalez, N.M.D., D.Sc., Ph.D. (Puerto Rico)
    William B. Grant, Ph.D. (USA)
    Tonya S. Heyman, M.D. (USA)
    Suzanne Humphries, M.D. (USA)
    Ron Hunninghake, M.D. (USA)
    Michael Janson, M.D. (USA)
    Robert E. Jenkins, D.C. (USA)
    Bo H. Jonsson, M.D., Ph.D. (Sweden)
    Jeffrey J. Kotulski, D.O. (USA)
    Peter H. Lauda, M.D. (Austria)
    Thomas Levy, M.D., J.D. (USA)
    Homer Lim, M.D. (Philippines)
    Stuart Lindsey, Pharm.D. (USA)
    Victor A. Marcial-Vega, M.D. (Puerto Rico)
    Charles C. Mary, Jr., M.D. (USA)
    Mignonne Mary, M.D. (USA)
    Jun Matsuyama, M.D., Ph.D. (Japan)
    Dave McCarthy, M.D. (USA)
    Joseph Mercola, D.O. (USA)
    Jorge R. Miranda-Massari, Pharm.D. (Puerto Rico)
    Karin Munsterhjelm-Ahumada, M.D. (Finland)
    Tahar Naili, M.D. (Algeria)
    W. Todd Penberthy, Ph.D. (USA)
    Dag Viljen Poleszynski, Ph.D. (Norway)
    Jeffrey A. Ruterbusch, D.O. (USA)
    Gert E. Schuitemaker, Ph.D. (Netherlands)
    Thomas L. Taxman, M.D. (USA)
    Jagan Nathan Vamanan, M.D. (India)
    Garry Vickar, MD (USA)
    Ken Walker, M.D. (Canada)
    Anne Zauderer, D.C. (USA)

    Andrew W. Saul, Ph.D. (USA), Editor-In-Chief
    Editor, Japanese Edition: Atsuo Yanagisawa, M.D., Ph.D. (Japan)
    Robert G. Smith, Ph.D. (USA), Associate Editor
    Helen Saul Case, M.S. (USA), Assistant Editor
    Ralph K. Campbell, M.D. (USA), Contributing Editor
    Michael S. Stewart, B.Sc.C.S. (USA), Technology Editor
    Jason M. Saul, JD (USA), Legal Consultant

    Comments and media contact: drsaul@doctoryourself.com OMNS welcomes but is unable to respond to individual reader emails. Reader comments become the property of OMNS and may or may not be used for publication.

    To subscribe to the Orthomolecular Medicine News Service (free): http://www.orthomolecular.org/subscribe.html

    OMNS Archive: http://orthomolecular.org/resources/omns/index.shtml

    To view this article on the OMNS website: http://www.orthomolecular.org/resources/omns/v14n17.shtml

  • BASHING VITAMINS BY META-ANALYSIS – SATIRICAL COMMENTARY BY ORTHOMOLECULAR NEWS

    Fred Liers PhD vitamins meta analysis orthomolecular news serviceDr. Andrew Saul, editor of the Orthomolecular News Service (OMNS), recently wrote a satirical commentary "How to Bash Vitamins with a Meta-Analysis." This satire takes the form of a memorandum from the world headquarters of pharmaceutical politicians, educators, and reporters (WHOPPER).

    The specific vitamin-bashing meta-analysis which prompted Dr. Saul's satire is titled  "Supplemental Vitamins and Minerals for CVD Prevention and Treatment" and published in Journal of the American College of Cardiology. The meta-analysis finds nutritional supplements useless, or with negligible benefit, and even dangerous. These conclusions would be laughable except that it is presented to the public as based on sound science. It is not.

    Of note is the fact that the meta-analysis relies on studies using low-dose supplementation, as well as studies using synthetic forms of vitamins and not natural coenzyme forms. For example, folic acid instead of natural folates.

    Meta-analyses such as this one are tired, trite, and re-cycled every few years, as if somehow they are "news." Moreover, the meta-analysis discloses significant conflicts of interest, which not only is disturbing, but also indicates a bias against supplements that makes its false conclusions even less trustworthy.

    We re-publish Dr. Saul's satirical commentary in full below. It is important to put truth distorting meta-analyses like this one in their place on the spectrum of truth. In the case of this meta-analysis, it is literally off the chart. (Pun intended.) ~

    FOR IMMEDIATE RELEASE
    Orthomolecular Medicine News Service, May 29, 2018

    How to Bash Vitamins with a Meta-Analysis

    A Confidential Memorandum from the World Headquarters of Pharmaceutical Politicians, Educators and Reporters (WHOPPER)

    Satire by Andrew W. Saul, Editor

    TOP SECRET: Do Not Let This Get on the Internet! No Leaks!

    Distinguished members, our decades of disparaging nutritional therapy have paid off at last. The public, and their healthcare providers, are completely hoodwinked. By pushing "evidence based medicine" on the medical professions, we have elegantly slipped in our choice of evidence to base medicine on. And this is no mere journeyman accomplishment: this is high art. Mr. Machiavelli would be pleased. Certainly the pharmaceutical cartel is. We are well on our way to eliminating the competition, namely that increasingly irritating "orthomolecular medicine" faction.

    Here's how we are winning the Vitamin War: It is entirely too obvious, from our reading the nutritional literature, that vitamins and minerals are a well-proven, safe and effective therapy. Of course, anyone knows that to work they must be employed in appropriate doses, just as any drug must be given in an appropriate dose. That is the problem, but it is also our opportunity. Since high nutrient doses work all too well, we eliminate all those embarrassing positive high-dose studies simply by ignoring them. By selecting, pooling and analyzing only unsuccessful low dose studies, our conclusions exactly fit what we want the public to believe.

    We have established that research data can easily be cherry-picked and meta-analyzed to further our agenda. And, of course, the huge amount of cash we spend on advertising assures that both the medical journals and the mass media will limit discussion to what we approve of. It is now a mere step to do the same in other disciplines, including education, politics, and the social sciences. For example:

    • Using data only from poorly funded urban schools, we can prove mathematically, by statistical analysis of grade-point-averages, that inner-city kids have no academic future.
    • By collecting data as to how many 19th century women graduated from college, we can show that women then were not as qualified to vote as men are today, and overturn the 19th amendment.
    • If we assemble data on screen time and analyze actors' roles from Hollywood movies made in the 1920s and 1930s, we can demonstrate that some races are best qualified to be domestic workers, tap dancers or to operate laundries.
    • By giving a large sample of the homeless 25 cents each, we can show that higher personal income is ineffective against poverty.
    • If we tabulate inventory at Ferrari dealerships exclusively, we can prove Hondas are scarce.
    • Repeatedly taking the temperature of thousands of cadavers is justification that funeral homes do not need central heating, at least not at night.

    Here is unlimited opportunity for social engineering. It logically proceeds from our widely publicized analyses of vitamin supplementation, analyses that were (of course!) limited to studies that used low doses. Political mathematics is a wonderful thing: select your data and meta-analyze it into truth.

    Don't worry: the public will accept it. After all, we just did a meta-analysis of the words of Abraham Lincoln. What he REALLY meant to say is that you can fool all of the people all of the time.

    We shall continue to act accordingly.

    (End of memo)

    The above satirical commentary is in reply to yet another vitamin-bashing report. This particular one is Supplemental vitamins and minerals for CVD prevention and treatment. J Amer Col Cardiology 2018, 71:22.

    The Orthomolecular Medicine News Service strongly disagrees with allegations that supplements are basically useless or even harmful.

    Dr. Michael Ellis (Australia) says:

    "There are hundreds of papers in the New England Journal of Medicine, JAMA, and other journals which support the use of orthomolecular medicine to prevent and cure chronic disease. The paper discussed here does not take into account dosages of vitamins and bioavailability. The meta analyses are therefore biased and not accurate."

    Dr. Damien Downing (United Kingdom) says:

    "This should be a rule: never trust a study with more metadata than data. This study is a review of reviews - a meta-meta-analysis. Selecting multiple studies introduces another level of judgment, with new potential for bias. Just as peer reviewers can introduce their own bias, so can review authors; some evidence indicates that reviewers bias selection significantly in favor of their own final conclusions."

    The financial interests of the study's authors makes VERY interesting reading. To see this truly enormous list, you have to scroll way, way down at https://www.sciencedirect.com/science/article/pii/S0735109718345601 Interestingly, if you download the paper, you do not get the conflict of interest section with it. You have to see it online to get the whole story. How about that.

    (Andrew W. Saul has been Editor-in-Chief of the Orthomolecular Medicine News Service for 14 years. You can watch videos where he rebuts other attacks against vitamin and mineral supplements at https://www.youtube.com/watch?v=88aUHMP3eN8&index=2&list=PL7YKya_R1ROuUyBFbKLeAp8iIITihxB-g and also at https://www.facebook.com/themegavitaminman/videos/265980030275194/ )

    Nutritional Medicine is Orthomolecular Medicine

    Orthomolecular medicine uses safe, effective nutritional therapy to fight illness. For more information: http://www.orthomolecular.org

    Find a Doctor

    To locate an orthomolecular physician near you: http://orthomolecular.org/resources/omns/v06n09.shtml

    The peer-reviewed Orthomolecular Medicine News Service is a non-profit and non-commercial informational resource.

    Editorial Review Board:

    Ilyès Baghli, M.D. (Algeria)
    Ian Brighthope, M.D. (Australia)
    Prof. Gilbert Henri Crussol (Spain)
    Carolyn Dean, M.D., N.D. (USA)
    Damien Downing, M.D. (United Kingdom)
    Michael Ellis, M.D. (Australia)
    Martin P. Gallagher, M.D., D.C. (USA)
    Michael J. Gonzalez, N.M.D., D.Sc., Ph.D. (Puerto Rico)
    William B. Grant, Ph.D. (USA)
    Tonya S. Heyman, M.D. (USA)
    Suzanne Humphries, M.D. (USA)
    Ron Hunninghake, M.D. (USA)
    Michael Janson, M.D. (USA)
    Robert E. Jenkins, D.C. (USA)
    Bo H. Jonsson, M.D., Ph.D. (Sweden)
    Jeffrey J. Kotulski, D.O. (USA)
    Peter H. Lauda, M.D. (Austria)
    Thomas Levy, M.D., J.D. (USA)
    Homer Lim, M.D. (Philippines)
    Stuart Lindsey, Pharm.D. (USA)
    Victor A. Marcial-Vega, M.D. (Puerto Rico)
    Charles C. Mary, Jr., M.D. (USA)
    Mignonne Mary, M.D. (USA)
    Jun Matsuyama, M.D., Ph.D. (Japan)
    Dave McCarthy, M.D. (USA)
    Joseph Mercola, D.O. (USA)
    Jorge R. Miranda-Massari, Pharm.D. (Puerto Rico)
    Karin Munsterhjelm-Ahumada, M.D. (Finland)
    Tahar Naili, M.D. (Algeria)
    W. Todd Penberthy, Ph.D. (USA)
    Dag Viljen Poleszynski, Ph.D. (Norway)
    Jeffrey A. Ruterbusch, D.O. (USA)
    Gert E. Schuitemaker, Ph.D. (Netherlands)
    Thomas L. Taxman, M.D. (USA)
    Jagan Nathan Vamanan, M.D. (India)
    Garry Vickar, MD (USA)
    Ken Walker, M.D. (Canada)
    Anne Zauderer, D.C. (USA)

    Andrew W. Saul, Ph.D. (USA), Editor-In-Chief
    Editor, Japanese Edition: Atsuo Yanagisawa, M.D., Ph.D. (Japan)
    Robert G. Smith, Ph.D. (USA), Associate Editor
    Helen Saul Case, M.S. (USA), Assistant Editor
    Ralph K. Campbell, M.D. (USA), Contributing Editor
    Michael S. Stewart, B.Sc.C.S. (USA), Technology Editor
    Jason M. Saul, JD (USA), Legal Consultant

    Comments and media contact: drsaul@doctoryourself.com OMNS welcomes but is unable to respond to individual reader emails. Reader comments become the property of OMNS and may or may not be used for publication.

    To subscribe to the Orthomolecular Medicine News Service (free): http://www.orthomolecular.org/subscribe.html

    OMNS Archive: http://orthomolecular.org/resources/omns/index.shtml

    To view this article on the OMNS website: http://www.orthomolecular.org/resources/omns/v14n16.shtml

    Read abstract of the meta-analysis: "Supplemental Vitamins and Minerals for CVD Prevention and Treatment." J Am Coll Cardiol. 2018 Jun 5;71(22):2570-2584. doi: 10.1016/j.jacc.2018.04.020.

  • HOW TO MAKE KETO COFFEE USING pH ADJUST

    Fred Liers PhD keto coffee pH Adjust alkalinizeWe can all stand to be more alkaline. The majority of people are acidic due to diet and lifestyle. One of the best formulas for creating alkalinity is pH Adjust. pH Adjust is a good-tasting, fluffy white powder that dissolves easily in water, juice, and yes, coffee.

    Shortly after launching pH Adjust as a new product, we began receiving reports from customers that they used pH Adjust in their coffee.

    Why put pH Adjust into coffee? Well, first it is a pleasant and convenient carrier for pH Adjust. Second, and most importantly, coffee is acid-forming in the body. By putting pH Adjust directly into coffee, you both can counteract acidity and simultaneously alkalinize the body.

    My questions: Was coffee creating acid condition in my body? And would putting pH Adjust in my coffee make a a difference? Short answer: Yes.

    I enjoy coffee. I don't drink it all the time. But after hearing customer comments, I decided to try pH Adjust in my coffee. Within a day or two, I noticed my teeth were stronger! This was welcome news.

    In fact, I had been dealing with a few "minor" dental issues, including teeth chipping, enamel wear, and occasional tooth pain. My diet is good and I eat plenty of vegetables and fruits. So how could my teeth be compromised?

    I measured my pH using Hydrion pH paper. It was lower than I thought it would be. Simply put: I was more acidic, more of the time, than I knew. Does acidity weaken teeth? Yes, it does.

    ph Adjust keto coffee pH Adjust alkalinizes the body rapidly. It dissolves easily in water, coffee & most drinks.

    "Bicarbonate reserves" decline as we age. This makes us more acidic because we don't buffer acidity as easily as we did when younger. The body must then draw upon minerals in bones and teeth. Yet, even young people are overly acidic in modern society. Everyone who is acidic stands to benefit from increased pH levels. That means most of us.

    The proof that acidity causes weaker teeth is the fact that pH Adjust immediately stopped my tooth chipping, enamel wear, and pain. Good thing I put pH Adjust into coffee shortly after HPDI introduced it. And thanks to the customers, employees, and friends of HPDI who told me about it.

    ALKALINIZING COFFEE IS HEALTHIER

    Coffee with pH Adjust is healthier than plain coffee because it helps alkalinize the body. Taking pH Adjust (without coffee) accomplishes the same thing. But for those who enjoy coffee, adding pH Adjust is an easy way to alkalinize what can otherwise be an acidifying drink. Who wants acidity? Not me.

    I now use pH Adjust in coffee by directly adding a 1/2 to 1 teaspoon directly into coffee and stirring. I adjust the dose according to how much coffee I drink.

    I also take pH Adjust separately from coffee—usually once or twice daily—about one teaspoon per dose. Taking 1–2 teaspoons total of pH Adjust daily seems to be the right amount. I no longer have issues with my teeth. My bones feel stronger, too.

    If you drink coffee, then adding pH Adjust to make it "pH Adjust coffee" may be helpful to you. It reduces acidity and supports mineral balance. It especially provides good levels of potassium and magnesium, minerals that are required for good health—and that are deficient in most people.

    If coffee is driving acidity in your body, then pH Adjust may be just the thing for you. Putting pH Adjust in your coffee directly means stopping acidity at the source. pH Adjust dissolves easily in coffee (and most other drinks) and does not add a bad taste. In fact, many people, including me, enjoy the gently sweet flavor it imparts.

    pH test paper litmus keto coffee Test pH using Hydrion litmus paper.

    KETOGENIC COFFEE WITH pH ADJUST

    More recently, I discovered the benefits of using organic coconut or MCT oil in coffee with organic pasture butter or ghee. This is based on the concept of Bulletproof coffee popularized by Dave Asprey in his Bulletproof Diet, and it fits well into ketogenic diets. Ketogenic diets are low in carbohydrates, high in fats, and include plenty of high-quality protein.

    I do not follow a ketogenic diet per se. Yet, I consume relatively high amounts of "good" fats (like coconut, olive, and avocado oils) and few simple carbohydrates. I had even added coconut oil, butter, and ghee into my coffee years ago. But I never blended it into an emulsified concoction, nor was pH Adjust available. So this is truly different!

    MAKE KETO COFFEE

    I make ketogenic or "keto" coffee using freshly ground organic coffee, organic coconut oil and/or organic MCT oil, and organic unsalted ghee (or pasture butter). It is important the ingredients be organic and pasture fed when possible.

    I first brew the coffee, then add coconut oil or MCT oil, and butter or ghee. Then I use a hand blender (or regular blender) to mix completely.

    INGREDIENTS

    • 8–16 ounces freshly brewed coffee

    • 1–2 tablespoons of Coconut oil or MCT oil

    • 1 teaspoon–2 tablespoons of unsalted ghee (or unsalted pasture butter)

    • 1/2 tsp–2 teaspoons pH Adjust (to taste, depending on quantity desired)

    Put freshly brewed coffee in a blender or large container (like a mason jar). Add coconut oil/MCT oil,  ghee, and pH Adjust. Blend or use hand blender to mix well. It is important the coffee be hot (or at least warm) in order for the coconut/MCT oil and ghee to mix into it.

    You can add the pH Adjust either before or after you mix or blend the coffee. I personally stir in the pH Adjust manually using a long spoon after I've already mixed the other ingredients. If you add the pH Adjust after mixing the other ingredients, then be sure to stir well.

    Note on amounts: the amounts I list above are suggestions. I often use less coconut or MCT oil, or ghee. That is, some days I use just two teaspoons of coconut/MCT oil, or one rounded teaspoon of ghee. Try using different amounts of ingredients to see what works for you.

    Keto Coffee Ghee Butter Grass-fed ghee is a key ingredient in keto coffee.

    One reason for using less coconut/MCT oil or ghee is because this coffee can be "filling." I am not hungry after I drink it. This is one benefit according to keto coffee experts. In fact, it is recommended that users drink it in the morning before eating. This gives the option of putting off breakfast.

    If I have planned to eat breakfast, then I will often use less coconut or MCT oil. The lower level of satiety from the coffee means I eat breakfast without having already been filled by the keto coffee.

    Make keto coffee any time of day. It is probably best on an empty stomach and definitely not too late into the afternoon—unless you want to be up late (if coffee affects you that way). You can make it early in the day, and then consume it over the course of the morning and afternoon.

    Benefits of Coffee or Keto Coffee with pH Adjust

    • Alkalinizes body — an alkaline state is good for overall health

    • Provides minerals, especially potassium and magnesium

    • May help strengthen teeth and bones

    • Some users report improved digestion

    • Some users report reduced GERD

    • Some users report less Restless Leg Syndrome (RLS)

    • Potassium helps balance out sodium — and is required for cellular health

    • Magnesium is essential for 400 enzyme systems, production of ATP, cardiovascular health, and muscle relaxation

    • Many other benefits!

    There are many other benefits associated with an alkaline state, which is ideally a pH of 7.35–7.45. You can learn more about the benefits of alkalinization from earlier HPDI blog articles (see resources section below), doing web searches, or talking to your health professional.

    If these benefits are not sufficient reason to try using pH Adjust in your coffee to make "pH Adjust alkalinizing coffee" then consider doing it for the taste!

    Tip: To make this coffee more hydrating, try adding 8-16 drops of Patrick Flanagan's Crystal Energy, which makes the water in this drink more bioavailable.

    keto coffee ingredients MCT oil ghee

    KETO COFFEE TASTES GOOD

    Keto coffee tastes good. The oils and fats provide a rich, hearty taste. It is creamy, warm, and delicious. And as I mentioned, it is filling, so it satisfies hunger.

    Adding pH Adjust to keto coffee won't change the taste much. In fact, many people say adding pH Adjust makes it taste better. I agree. This may be due to the fact that the formula contains glycine in the form of potassium glycinate. Glycine tastes good and is naturally "sweet" without the harmful effects of sugar. In fact, to me pH Adjust imparts a slightly sweet flavor that is reminiscent of "caramel."

    pH Adjust may slightly change the texture of your coffee. It may make regular, non-keto coffee appear and taste "creamier." Most people won't mind that. As for keto coffee, it is already "creamy" due to the coconut/MCT oil and ghee. pH Adjust might just add a bit more texture to it.

    Also, there may be a slight chalky, white residue at the bottom of your cup. This does not happen if you mix in the pH Adjust formula well, or if you re-stir (or swirl) the coffee cup or glass when it's half full. Remember: if you see this residue, it is pH Adjust. As such, you may wish to drink it as is, or add little more liquid (coffee, water, etc.) and quaff it down.

    keto coffee blender drink Mix the MCT or coconut oil and ghee (or butter) using a blender or stick blender.

    DRINK pH ADJUST FOR ALKALINITY

    To me, the most important thing about coffee or keto coffee with pH Adjust is not how it tastes or how it reduces hunger, etc. It is how is increases pH levels. Alkalinity is important for health. No matter how you choose to take or drink it, pH Adjust will alkalinize. In spades.

    Besides coffee, you can add pH Adjust to juices, teas, smoothies, shakes, water, and even lemonade. The fact is, taking pH Adjust is more important than the drink you choose to take it with. You decide the drink.

    That being said, I really like keto coffee with pH Adjust. I add ice for a delightful, cooling concoction in summer. In winter, I drink it hot.

    I think you will enjoy keto coffee with pH Adjust, too. And, if you already brew and drink your own version of keto coffee, then increased alkalinity—and better health—is as simple as adding a spoonful of pH Adjust. ~

    RESOURCES

    HPDI BLOG ARTICLES

    Alkalizine with Lemonade Diet and pH Adjust

    Got Potassium?

    Racing and Recovery with pH Adjust Alkalinizing Formula

    Alkalinize Rapidly Using pH Adjust

    pH Adjust Alkalinizing Formula – New Product!

    BOOKS & ARTICLES

    Acid-alkaline balance: role in chronic disease and detoxification
    (Altern Ther Health Med, 13(4):62-5)

    Acid & Alkaline by Herman Aihara

    Bicarb Magical Mineral Supplement by Dr. Mark Sircus, Ac, OMD

    The Bulletproof Diet by Dave Asprey

    Head Strong by Dave Asprey

    The High Blood Pressure Solution by Richard D. Moore, MD, PhD

    The K Factor: Reversing and Preventing High Blood Pressure without Drugs by Richard D. Moore, MD, PhD

    Keto: The Complete Guide to Success on The Ketogenic Diet by Maria Emmerich

    Simply Keto: A Practical Approach to Health & Weight Loss by Suzanne Ryan

    The XXL Syndrome by Max Rombi, MD

    LISTS & REFERENCE

    The Acid Alkaline Food Guide
    by Dr. Susan Brown and Larry Trieviei, Jr.

    Potassium Intake of the US Population (PDF)
    (NHANES Food Surveys Research Group, USDA)

    Potassium: Health Benefits, Recommended Intake

    List of acid-forming and alkaline forming foods

    PRODUCTS

    pH Adjust
    (Dr. Hank Liers' original formula)

    pH paper (roll)
    (Hydrion litmus paper)

  • GENETICS, EPIGENETICS & HUMAN BIOLOGY

    Genetics, Epigenetics, and Human Biology

    Dr. Hank Liers, PhD geneticsWe are entering a time in which new scientific tools are available that provide clear insights regarding the causes of poor health, as well as therapies that can be used to overcome health issues. Specifically, these tools include 1) our understanding and ability to characterize the human genome, and 2) advances in the science of epigenetics showing how environmental factors significantly influence the expression of genetics and human biology.

    For many years, my company (Health Products Distributors, Inc. – "HPDI") has been involved in Rejuvenation/Healing Programs which take multiple health modalities into consideration (for information on HPDI's Rejuvenation/Healing Programs, see Additional Resources below). Our programs have generally involved the following elements:

    1. Health-Building Nutrition
      Rejuvenation begins with nutrition in the broadest sense. That is, nutrition derived from healthy foods, superfoods, supplements, dietary nucleic acids, water and fluids, as well as via the skin. Establishing health-building nutrition is foundational to rejuvenating the body, mind, and spirit.
    2. Detoxification & Preventing Toxicity
      Individuals cannot fully experience rejuvenation without having effective means for removing existing toxins form the body, or for stopping further accumulation of toxins absorbed from foods, air, water, and skin. Such toxins include everything from chemicals in foods and water to the many toxins found in homes, workplaces, personal products, and just about everywhere.
    3. Building Powerful Immunity
      Building immunity is important for health because the immune system is the means by which the body defends itself. Yet, if the best defense is a strong offense, then having a strong immunity protects us in ways beyond just defense. Building immunity is accomplished not only by nutrition, but also by utilizing herbs, immune boosting supplements, and immune-enhancing protocols.
    4. Supporting Protocols
      Certain practices and protocols powerfully support rejuvenation. These protocols include exercise, massage, saunas/hydrotherapy,  yoga, acupuncture, meditation, and others.
    5. Attitude and Commitment to Becoming Healthy
      Attitude and Commitment are foundational to your rejuvenation/healing program because having total focused intention regarding your health is essential for success. If a journey of a thousand miles begins with a single step, establishing that intention perspective is a great place to start.

    ADDING GENETICS TEST TO HPDI REJUVENATION PROGRAM

    In the last few years, we have seen how healing and wellness programs can be significantly enhanced by adding genetics testing into the mix. In fact, we have joined forces with BodySync, a company with the most advanced single genetics test available. This test characterizes 45 different genes and gene variations. The Bodysync genetics test results are combined with basic lifestyle information provided by the patient to create a complete program customized for dealing with gene variations having either harmful or helpful effects.

    The insights gleaned by taking the BodySync genetics test provides new insights into reasons a person may experience health challenges that no other method can provide. The test results and action plan also provide information regarding genetic strengths, especially related to athletic performance and weight management.

    The NutriSync test from BodySync genetics

    HPDI now adds the BodySync genetics test to the list of key elements in our rejuvenation/healing programs. In fact, we are now introducing the BodySync genetic test along with consultations to our HPDI Reseller Associates—so that health practitioners (HPs) can experience the benefits of the test for themselves— and see how genetics consulting can be added to their practice. In addition, BodySync has selected HPDI as their preferred supplier of nutritional supplements supporting the recommendations provided in their Action Plans for individuals taking the test. It is exciting to be part of this breakthrough in the practice of genetic science.

    BROAD OVERVIEW OF GENETICS, EPIGENETICS, AND HUMAN BIOLOGY

    In order to give a more complete understanding of our program for attaining excellent health, we have developed a broad scientific overview of how all the key elements are related and eventually expressed as YOU.

    The diagram below provides a broad overview of genetics, epigenetics, and human biology with the goal of showing how the elements are interrelated. More discussion on the key elements is provided below the diagram.

    Genetics, Epigenetics, and Human Biology genetics

     

    GENOME

    The human genome is the sum of the body's DNA and is considered to be static for each individual—remaining the same over a lifetime. The human genome contains all the instructions needed to make the full range of human cell types including muscle cells and neurons. This includes all of the body's DNA, both the genes (the coding regions) and the noncoding DNA, as well as the genetic material of the mitochondria and chloroplasts.

    With the breakthrough in gene testing now available, it is possible to isolate relevant genes from a field of  approximately 20,000 different genes. These 20,000 different genes make up less than 2% of the total amount of DNA.

    It has been found that the underlying gene patterns can exhibit "genetic variations". Ultimately, genetic variations are caused by variations in the order of bases in the nucleotides in genes. New technology, such as that used in the BodySync genetics test, allows scientists to directly sequence DNA which has identified even more genetic variation than was previously detected by previous methods such as protein electrophoresis.

    Examination of DNA has shown genetic variation in both coding regions and in the non-coding intron (nonprotein-coding sections) region of genes. Mutation is the ultimate source of genetic variation, but mechanisms such as sexual reproduction and genetic drift contribute to it as well.

    Genetic variation will result in phenotypic variation if variation in the order of nucleotides in the DNA sequence results in a difference in the order of amino acids in proteins coded by that DNA sequence, and if the resultant differences in amino acid sequence influence the shape, and thus the function of the enzyme.

    Genetic variations/base substitutions can change a codon to one that encodes a different amino acid and cause a small change in the protein produced. For example, sickle cell anemia is caused by a substitution in the beta-hemoglobin gene, which alters a single amino acid in the protein produced.

    Genetic variations can change a codon to one that encodes the same amino acid and causes no change in the protein produced. These are called silent mutations.

    Also, base substitutions can change an amino-acid-coding codon to a single "stop" codon and cause an incomplete protein. This can have serious effects since the incomplete protein probably won't function.

    In some genetic variations there may be a piece of the DNA deleted or inserted in a gene that may also lead to Present/Insertion or Deletion variation (INDEL). Since protein-coding DNA is divided into codons three bases long, insertions and deletions can alter a gene so that its message is no longer correctly parsed.

    When it comes to genetic traits, scientists look at genes and the locus where that gene or trait encodes on the chromosome. Since humans possess two copies of each chromosome, they also have two copies of each gene and locus on those chromosomes. Each of these trait-encoding genes (or loci) is called an allele. If the alleles match, the person is homozygous for that trait. If the alleles are different, the person is heterozygous for that trait.

    If a mutation occurs in just one copy of the gene then that individual is considered heterozygous. On the other hand if both copies of a gene are mutated then that individual is homozygous genotype. Many of these mutations can have undesirable health affects for an individual.

    BodySync's technology has helped to usher in the age of personalized nutrigenomics. The company has built its intellectual property and technology to support its vision of providing services in partnership with health care professionals (HP). BodySync's NutriSync (NS) genetics test consists of only the most well-researched genetic variations with direct applicability to actionable personalized health and wellness recommendations (most of which fall into the epigenetic category).

    The NutriSync genetics test has been based on evaluations of thousands of peer reviewed articles, published research papers, and human intervention studies, as well as extracting data of tens of thousands of DNA and self-reported lifestyle samples in its database.

    EPIGENOME

    The human epigenome serves as a bio-record of chemical changes that have occurred in a person's DNA and their histone proteins. Unlike the underlying genome which is largely static within an individual, the epigenome can be dynamically altered by environmental conditions. For example methyl groups from the diet can tag DNA and activate or repress certain genes as shown in the diagram below.

    The epigenome is involved in regulating gene expression, development, tissue differentiation, and suppression of transposable elements. These changes in underlying DNA and histone proteins can be passed down to an organism's offspring via transgenerational epigenetic inheritance. Changes to the epigenome can result in changes to the structure of chromatin and changes to the function of the genome.

    EPIGENETICS

    Epigenetics, on the other hand, is the study of changes in gene expression (active versus inactive genes) that do not involve changes to the underlying DNA sequence — a change in phenotype (the manifestation that is YOU) without a change in genotype — which in turn affects how cells read the genes. To be sure, epigenetic change is a regular and natural occurrence in our bodies, but can also be influenced by several factors including age, the environment/lifestyle, drug usage, and disease state.

    Epigenetic modifications can manifest as commonly as the manner in which cells terminally differentiate to end up as skin cells, liver cells, brain cells, etc. Also, epigenetic change can have more damaging effects that can result in diseases like cancer. At least three epigenetic mechanisms (two of which are shown in the diagram below) including DNA methylation, histone modification, and non-coding RNA (ncRNA)-associated gene silencing are currently considered to initiate and sustain epigenetic change.

    genetics epigenetics mechanisms

    ENVIRONMENT

    In this context the term "ENVIRONMENT" refers to all of the "external" influences we experience. In the diagram we list what are generally considered to be positive and negative factors contributing to our overall health.

    Some of these factors such as free-radicals and drug use affect our genome directly. Environmental agents such as UV light, ionizing radiation, and genotoxic chemicals (e.g. the drug thalidomide) can cause DNA damage. DNA damage is very frequent, occurring on average about 10,000 times a day per cell of the human body.

    These damages are largely repaired, but at the site of a DNA repair, epigenetic changes can remain. In particular, a double strand break in DNA can initiate unprogrammed epigenetic gene silencing both by causing DNA methylation, as well as by promoting silencing types of histone modification.

    The field of epigenetics is rapidly growing and with it the understanding that both the environment and individual lifestyle directly interact with the genome to influence changes in the way various genes are expressed. These changes may be reflected at various stages throughout a person’s life and even in later generations. For example, human epidemiological studies have provided evidence that prenatal and early postnatal environmental factors influence the adult risk of developing various chronic diseases and behavioral disorders.

    Also, research has also shown that a mother’s exposure to pollution could impact her child's asthma susceptibility and her intake of Vitamin D could change DNA methylation that influences placenta functioning. It doesn’t stop at the mother, however, as further studies support that the father has a hand in his child’s health and epigenetic marks, as well.

    Although our epigenetic marks are more stable during adulthood, they are still thought to be dynamic and modifiable by lifestyle choices and environmental influence. It is becoming more apparent that epigenetic effects occur not just in the womb, but over the full course of a human life span, and that epigenetic changes could be reversed. There are numerous examples of epigenetics that show how different lifestyle choices and environmental exposures can alter marks on top of DNA and play a role in determining health outcomes.

    The environment is being investigated as a powerful influence on epigenetic tags and disease susceptibility. Pollution has become a significant focus in this research area as scientists are finding that air pollution could alter methyl tags on DNA and increase one’s risk for neurodegenerative disease. Also, adequate amounts of B vitamins may protect against harmful epigenetic effects of pollution and may be able to combat the harmful effects that particulates have on the body.

    Diet has also been shown to modify epigenetic tags in significant ways. The field of nutriepigenomics explores how food and nutritional supplements and epigenetics work together to influence health and well being. For example, a study found that a high fat, low carbohydrate diet could open up chromatin and improve mental ability via HDAC (histone deacetylase) inhibitors.

    Other studies have found that certain compounds within the foods we consume could protect again cancer by adjusting methyl marks on oncogenes or tumor suppressor genes. Ultimately, an epigenetic diet may guide people toward the optimal food regimen as scientific studies reveal the underlying mechanisms and impact that different foods have on the epigenome and health.

    RNA/PROTEIN

    Ribonucleic acid (RNA) is a polymeric molecule essential in various biological roles in coding, decoding, regulation, and expression of genes. RNA and DNA are nucleic acids, and, along with lipids, proteins and carbohydrates, constitute the four major macromolecules essential for all known forms of life.

    Like DNA, RNA is assembled as a chain of nucleotides, but unlike DNA it is more often found in nature as a single-strand folded onto itself, rather than a paired double-strand. Cellular organisms use messenger RNA (mRNA) to convey genetic information that directs synthesis of specific proteins.

    These protein molecules are the "workhorses" of the cell carrying out all the functions necessary for life. For example, enzymes, including those that metabolize nutrients and synthesize new cellular constituents, as well as DNA polymerases and other enzymes that make copies of DNA during cell division, are all proteins.

    PHENOTYPE

    Your phenotype is a description of your actual physical characteristics. This includes straightforward visible characteristics like your height and eye color, but also your overall health, your disease history, and even your behavior and general disposition. Do you gain weight easily? Are you anxious or calm? Do you like cats? These are all ways in which you present yourself to the world, and as such are considered phenotypes.

    However, not all phenotypes are a direct result of your genotype; chances are that your personal disposition to cats is the result of your life’s experience with pets (epigenetic) rather than a mutation in a hypothetical cat fancier gene.

    Most phenotypes are influenced by both your genotype and by the unique circumstances in which you have lived your life, including everything that has ever happened to you (epigenetic). We often refer to these two inputs as “nature,” the unique genome you carry, and “nurture,” the environment in which you have lived your life.

    HEALTH AND DISEASE

    Your phenotype expresses who YOU are in a multitude of ways and in particular shows your strengths and weaknesses regarding health, mental abilities, and athletic performance to name a few. By incorporating genetics and epigenetic tests and controlling your environment in positive ways your strengths can be expressed more easily and your weaknesses minimized!!

    CONCLUSION

    I have provided an overview of how genetics testing provides new scientific insights into many health issues that have previously not been well understood. An overview of genetics, epigenetic, and human biology has been provided that shows the overall relationships of these topics. Hopefully, the rationale is clear for adding genetic testing into programs that provide protocols for more successful healing regimens.

     

    ADDITIONAL RESOURCES

    HOMOCYSTEINE GENETICS – COENZYME B VITAMINS

    REJUVENATION PROGRAM SERIES

    Rejuvenation Program Part Ten: The Yoga Program

    Rejuvenation Program Part Nine: Acupuncture. Supporting Protocols Part Four – Acupuncture and Traditional Chinese Medicine (TCM).

    Rejuvenation Program Part Eight: Massage. Supporting Protocols Part Three – The Massage Program.

    Rejuvenation Program Part Seven. Supporting Protocols Part Two – The Magnesium Chloride Program

    Rejuvenation Program Part Six. Supporting Protocols Part One (garlic, hydrotherapy, and sauna therapy programs).

    Rejuvenation Program Part Five. Beyond foundational supplements. Seven enhancement supplements that supercharge your health. CoenzymeQ10 and/or Ubiquinol, Myo-Mag, Hepa Plus, Nascent Iodine, Echinacea, Immune-Assist™.

    Rejuvenation Program Part Four. The role of foundational supplements (multivitamin, Vitamin C / antioxidant formula, Rejuvenate!™ superfoods) for health.

    Rejuvenation Program Part Three. Health building nutrition and the role of dietary nucleic acids (RNA, DNA, nucleosides, and nucleotides).

    Rejuvenation Program Part Two. Foundational elements in the HPDI Rejuvenation Program: 1) Attitude/Commitment, 2) Detoxification, 3) Preventing Toxicity, 4) Health Building Nutrition, 5) Building Powerful Immunity, and 6) Supporting Protocols.

    Rejuvenation Program Part One. Introducing the HPDI Master Rejuvenation Program and its foundational elements. The importance of Attitude/Commitment.

     

  • RESTORE GUT HEALTH FORMULA + VIDEO

    Fred Liers PhD restore liquid mineral supplement gut healthHeard of RESTORE liquid mineral supplement? If not, you're about to discover something important for gut health.

    RESTORE™ is formulated to help restore gut health. It works by strengthening the integrity of tight junctions in your intestinal wall.

    Maintaining tight junctions is important because they protect your body from substances entering the blood stream. Restore also supports the communications systems of the bacteria in your microbiome.

    Tight junctions are natural barriers protecting the lining of your gut barrier, organs such as kidneys and heart, and the blood-brain barrier thereby keeping out unwanted substances. Even as we take in nutrients from the GI tract, the function of tight junctions is maintaining the integrity of the gut wall and other barriers that protect the body.

    These days, our gut membrane has a tough job keeping out unwanted substances. Because tight junctions are weakened by many things, including highly processed foods, especially those containing gluten and gliadin, the herbicide glyphosate (the primary ingredient in RoundUp weedkiller), and other exposures like electromagnetic fields (EMF) from digital devices and Wi-Fi networks.

    As a result of weakened tight junctions, undesirable substances from food proteins, harmful chemicals and other toxins can slip though into our bloodstream. This can lead to a powerful immune response that can weaken immunity and cause significant inflammation. Foreign substances in the bloodstream can also result in extreme food allergies and food sensitivities to various toxins entering the body.

    We live in an age in which our microbiome health is under assault.  Studies show our ancient ancestors had 20,000–30,000 different strains of beneficial bacteria in their GI tracts. Many people today have just 5,000 or less. Why is that?

    There are many reasons for low microbiome diversity. These reasons include antiobiotic use (both from pharmaceuticals and foods), glyphosate (which essentially acts like an antibiotic), processed foods (especially those containing gluten and gliadin), and systemic degradation of the gut environment rendering it less hospitable for maintaining health populations of gut flora.

    These impacts are significant because diversity in your microbiome not only supports gut health, but also appropriate  brain health, immune system health, and overall vitality. Restore acts as a "microbiome fertilizer" helping establish and maintain healthy microbiota.

    In fact, Restore contains important "redox" molecules produced millions of years ago by existing soil bacteria. These molecules are an important part of communications systems within the body between gut bacteria and with the body's mitochondria. These communication systems play an important role in establishing proper homeostasis throughout the body.

    REASONS TO USE RESTORE™

    There are important reasons to try Restore—whether or not you experience significant gut health issues. These reasons include:

    • Maintaining strong tight junctions for mega membrane health, and helping the body restore tight junction integrity

    • Creating an environment in which beneficial bacteria can thrive

    • Boosting microbiome diversity

    • Healing the gut

    • Mitigating the adverse effects substances like antibiotics, gluten/gliadin, glyphosate, and GMOs on microbiome health

    • Supporting immune system function

    • Protecting integrity of blood-brain barrier

    Other benefits include support for respiratory wellness, enhancing mental clarity, and promoting proper homeostasis throughout the body.

    For all these reasons and more, you should consider taking Restore. You can start by taking one teaspoon or less daily, and gradually increasing your dose to one tablespoon or more.Restore for gut health liquid supplement

    I have taken Restore daily for more than two years, and benefit greatly from it. The most noticeable effects are a complete cessation of spring allergies (after two decades of worsening symptoms), greater clarity of thinking, and improved overall well being. I have seen other people get good results with a variety of conditions from dysbiosis to gluten/gliadin sensitivity.

    MORE ABOUT RESTORE™

    You can learn more about Restore on our website. Also, the Restore website offers in-depth information and videos. Here is how the Restore website and Dr. Zach Bush describe the formula:

    Restore is a dietary supplement supplying first line defense against daily exposure to environmental and food-borne factors. It helps create an optimal environment or ecology in the gut membrane for beneficial or "good" bacteria to flourish. Beneficial gut flora protect your immune system and maintain health. Restore is a scientifically proven soil-derived mineral supplement designed to support protection of the intestinal walls.

    Restore protects the entire gastrointestinal (GI) tract against agricultural herbicides, antibiotics, GMOs, gluten, and food-borne toxins. It helps create an environment in which 20,000–30,000 different strains of beneficial gut bacteria can thrive. This is a far different mode of action from probiotics, most of which contain just 3–30 strains of beneficial bacteria.

    Restore helps create a strong immune system along with proper gut function. Microbiome balance and tight junction integrity are known to constitute a significant part of the immune system. They directly affect DNA transcription of cells to promote optimal health and prevent a leaky gut syndrome, thereby improving gut intelligence.

    Seventy percent (70%) of our immune system is found in our gut. We need tens of thousands different strains of good gut bacteria to support a healthy immune system. Clinical experience, in addition to cell culture studies, support the theory that Restore’s proprietary formula creates the optimal environment in the gut to create a tight junction barrier and maintain our health and wellness.

    Restore is a daily liquid supplement designed to support the protection of the entire gastrointestinal (GI) tract against agricultural herbicides, antibiotics, GMOs, gluten and food-borne toxins by helping to create an environment where between 20,000-30,000 different strains of good gut bacteria thrive. Most probiotics on the market contain fewer than 24 different strains of good gut bacteria.

    TRY RESTORE™

    Restore is ideal for individuals suffering from gut health issues. Yet, it is also excellent for supporting and maintaining gut health generally. That is the reason we at HPDI consider Restore important enough to designate as a foundational supplement, one of the top six supplements you need for good health.

    Given the safety and effectiveness of Restore, there is broad applicability for its use. This is especially true because gut and microbiome health are under constant assault. These assaults range from multiple environmental and lifestyle factors—including poor diets high in processed foods, antibiotics in pharmaceuticals and animal foods—to massive glyphosate (herbicide) contamination of foods, soils, air, and water.

    Let Restore be your first line of defense against assaults on your gut health, tight junctions, microbiome diversity, and immune function. As it says on the bottle, "Complete well-being begins in the gut."

    RESTORE RESOURCES

    Gut Health – Effects of Glyphosate and Antibiotics
    by Hank Liers, PhD and Fred Liers, PhD

    Restore - 32 oz

    Restore - 8 oz

    HPDI Gut Health Formulas

    HPDI Foundational Supplements

    Restore blog (Restore4Life)

  • REJUVENATE! PLUS SUPERFOOD — NEW IMPROVED FORMULA

    Fred Liers PhD rejuvenate! plus superfoodAs if Rejuvenate! PLUS weren't already the delicious, nutritious superfood you know and love. Now, Dr. Hank Liers, HPDI's formulator, has enhanced the formula for a truly remarkable taste and nutrition experience, you must try for yourself to believe!

    The name Rejuvenate! Plus remains, but think of it as "version 2.0" because the nutritional upgrades and taste improvements are striking.

    By the way, the "new" Rejuvenate! Plus is available now, so you can look forward to a truly remarkable user experience. We are confident you will be more than pleasantly surprised.

    You will not believe your tastebuds when you try the new Rejuvenate! Plus. My humble opinion? Dr. Hank (my father and HPDI's formulator) has knocked it out of the park in his revised formula.

    Reports from sample testers have been overwhelmingly positive! Individuals who loved Rejuvenate! Plus unanimously love the new formula even more. That says a lot about this reformulation.

    Rejuvenate! Plus sweet green superfood Rejuvenate! Plus 2.0 – healthy ingredients and taste at whole new level!

    Other testers, who preferred our Rejuvenate! Berries & Herbs or Original Greens formulas either say they will now add Rejuvenate! Plus to their regimen, or will mix it in with their current favorite Rejuvenate! superfood.

    Some individuals sampling the new formula who had never tried it before or previously did not often use Rejuvenate! Plus have decided to use it as their primary superfood—or take it daily.

    We couldn't be happier because these reports confirm the new Rejuvenate! Plus is a significant improvement over previous versions, and make our year-long effort to reformulate the product worth it. These early reports based on product samples show we have succeeded!

    Some things haven't changed: Rejuvenate! Plus remains the most popular and best-selling of all HPDI Rejuvenate superfoods. As always, it provide therapeutic levels (at least 340 mg) of dietary nucleic acids (RNA, DNA), greens (chlorella and spirulina) as in the lighter, sweeter greens (as compared to dark intense green-ness of Rejuvenate! Original greens) that both leads to slower, yet effective detoxification, and is powerfully energizing and cleansing. Rejuvenate! Plus also remains a foundational supplement that retains a complete built-in multivitamin sub-formula.

    What then has changed? In short, we have changed a few ingredients, added or upgraded other ingredients, increased protein and nucleic acids (RNA) content, and created better tasting product overall. Here is a brief summary:

    The "new" Rejuvenate! PLUS features (per serving):

    1) 500 mg more spirulina (1,900 mg total), which actually increases the RNA content by about 15 mg

    2) 2.3 grams more protein for a total of 13.9 grams

    3) Almost no sugar (just 0.6 g total)

    4) 2.3 g of powerful broccoli and alfalfa sprout extract powders

     5) 200 mg of organic BiAloe® aloe vera powder with over 18% acemannan

    6) 5-MTHF (500 mcg) — a better form of folate

    6) An extremely smooth texture, and even more delicious taste—users rate as significantly better than prior versions—which says a lot because Rejuvenate! Plus already tasted great.

    In short, these are the changes that make the new, improved Rejuvenate! Plus a significantly better product. Now I will delve a bit deeper into each of these changes, as well as specific changes to ingredients.

    Rejuvenate! Plus superfood The new Rejuvenate! PLUS offers major improvements for optimal health.

    REJUVENATE! PLUS IS A UNIQUE, HIGH-RNA SUPERFOOD

    Rejuvenate! Plus is one three high-RNA superfoods Hank Liers of HPDI intentionally formulated to provide therapeutic levels of dietary nucleic acids. In this case, that means about 340 mg of nucleic acids per serving, and that has now been increased to at least 355 mg. The fact that Rejuvenate! Plus provides such high levels of dietary nucleic acids makes it—and the entire line of Rejuvenate! superfoods—unique!

    A short history lesson: Benjamin S. Frank, MD, PhD discovered the benefits of dietary nucleic acids in the 1960s and 1970s. He performed various studies on humans and animals using various intakes of dietary RNA. He concluded that nucleic acids are essential nutrients like vitamins and minerals. Nucleic acids provide a host of unique health benefits that make getting RNA in your diet important.

    After reading of Dr. Benjamin S. Frank's works (including Dietary Nucleic Acid Nutrition and Therapy and The No-Aging Diet), my father Hank Liers and I decided to formulate a line of superfoods based on the idea of providing high levels of dietary nucleic acids for optimal health. That was 10 years ago.

    Rejuvenate! Original Greens launched in 2007. Rejuvenate! Plus came two years later in 2009. Then Rejuvenate! Berries & Herbs in 2010. To this day, no other company has created dedicated high-RNA superfoods like HPDI's Rejuvenate line.

    DIETARY NUCLEIC ACIDS IN REJUVENATE! PLUS

    What makes Rejuvenate! PLUS—and in fact the entire Rejuvenate! line of superfoods—unique? A single serving provides therapeutic levels (340+ mg) of dietary nucleic acids (RNA, DNA, nucleotides, and nucleosides). Here are a few of the benefits and effects of nucleic acids in the body:

    • HIGHER ENERGY (ATP) PRODUCTION
    • GREATER MUSCLE MASS / STRENGTH / ENDURANCE
    • SMOOTHER SKIN / MORE YOUTHFUL APPEARANCE
    • EASIER BREATHING / “ANTI-ANOXIA” EFFECT
    • ELEVATES TISSUE OXYGENATION
    • BENEFICIAL CARDIOVASCULAR EFFECTS
    • LOWER CHOLESTEROL LEVELS
    • OVERALL PHYSICAL REJUVENATION
    • TEMPERATURE TOLERANCE (COLD/HEAT)
    • IMPROVES LONGEVITY / QUALITY OF LIFE
    • FAR GREATER SUBJECTIVE WELL-BEING

    Source: Nucleic Acid Nutrition and Therapy

    Nucleic acids perform so many important functions in the body that getting sufficient amounts in the your diet is probably essential, just as Dr. Benjamin S. Frank asserts. That can be difficult since historically they were obtained from fish, organ meats—foods that people today may not consume in sufficiently high amounts for a variety of reasons. These reasons may include issues of taste, emphasis on vegetarian foods, concern about heavy metals or radiation, or lack of availability.

    Rejuvenate! Plus in many ways helps take the guesswork from obtaining "essential" dietary nucleic acids by providing a vegetarian, gluten free, and non-GMO source of dietary RNA—along with protein, vitamins, minerals, cofactors, and other important nutrients—in a tasty, easy-to-take powder that stays fresh for months, travels well, and can be taken in a variety of ways from smoothies to plain water!

    TRY REJUVENATE! PLUS

    You (or your clients) have everything to gain by trying Rejuvenate! PLUS. As you can see, the updated superfood is carefully formulated to help create and maintain optimal health.

    When used together with other HPDI foundational supplements and the HPDI supplement system, Rejuvenate! Plus is another "brick in your wall" of good health and can make a huge difference in terms of how you feel, perform, and function in life.

    Try the new, improved Rejuvenate! PLUS "2.0" superfood. See for yourself not only how good it tastes, but how good it can help make you feel. That's goodness all around!

    RESOURCES

    Articles

    Nine Things to Know About Rejuvenate Superfoods

    Dietary Nucleic Acids – Dr. Benjamin S. Frank, Part 1

    Dietary Nucleic Acids – Dr. Benjamin S. Frank, Part 2

    Super-Tasty Morning Nutritional Drinks

    Product Reviews

    Rejuvenate! PLUS Superfood is High in DNA and RNA with sprouts, chlorella & more by Mike Adams

    Product Review: Rejuvenate Berries & Herbs superfood is rich in RNA, plant proteins by Mike Adams

    Superfood for Cellular Survival by Dr. Mark Sircus

    Books

    Nucleic Acid Nutrition and Therapy by Benjamin S. Frank, MD, PhD

    Dr. Frank's No-Aging Diet: Eat and Grow Younger by Benjamin S. Frank, MD, PhD

    Nucleic Acid and Anti Oxidant Therapy of Aging and Degeneration by Benjamin S. Frank, MD, PhD

    Nucleic Acid Therapy in Aging and Degenerative Disease–A Metabolic Approach with DNA, RNA, and Related Metabolites by Benjamin S. Frank, MD, PhD

    Rejuvenate! Superfoods

    Rejuvenate! Superfoods

    Rejuvenate! comparison page

    Rejuvenate! PLUS

    Rejuvenate Berries & Herbs

    Rejuvenate! Original Greens

    Videos

1-6 of 81

Page:
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5
  6. ...
  7. 14