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  • EXCITING NEW TERRAFLORA SYNBIOTIC

    Terraflora Synbiotic

    Dr. Hank Liers, PhD Terraflora synbiotic probioticIt has finally arrived — the exciting new Terraflora™ synbiotic. A synbiotic is a combination of probiotics and supporting prebiotics. This advanced soil-based organisms formula fills the need for a superb probiotic/prebiotic in Health Products Distributors' arsenal of highly effective formulas. Terraflora is extremely supportive of your entire microbiome and gut-based immune system.

    If this sounds like an extremely useful formula—like it does to me—then keep reading about Terraflora™....

    ADVANCED GUT MICROBIOME SUPPORT

    INTRODUCING THE MICROBIOME

    For centuries, scientists have recognized a limited number of pathogenic bacteria for which antibiotic therapies have become the mainstream treatment. However, advanced DNA sequencing techniques coupled with data revealed from the Human Genome Project have made it possible to study a vast world of ‘germs’ – both pathogenic and beneficial – that dwarf our previous knowledge.

    While we inherit more than 22,000 genes from our parents, the bacteria that exist in and on our bodies contain at least eight million bacterial genes which amounts to 360 times more bacterial genes than human genes! The genetic material from bacteria that populate the human body is known as the human microbiome.

    Your microbiome is likely similar to that of your immediate family, as we naturally inherit our family’s microbiota. Through the course of our lives, we pick up other bacteria from food, water, and other parts of our environment. Scientists estimate we each carry 100 trillion bacteria in our intestinal tract alone!

    In this teeming landscape of bacteria, both you and the bacterial communities derive benefit. Many researchers use the term "mutually beneficial" when describing the evolving bacterial communities in our gut.

    THE BALANCE OF BACTERIA AND YOUR HEALTH

    In 2010, the Human Microbiome Project published an analysis of 178 genomes from bacteria that live in or on the human body. 10,000 different types of bacteria in the human body have been identified, including novel genes and proteins that serve functions in human health and disease. The vast numbers of bacteria discovered appear to provide benefit to the human body, not harm.

    Martin J. Blaser, chairman of the Department of Medicine and a professor of microbiology at the New York University (NYU) School of Medicine states: "Germs make us sick, but everyone focuses on the harm. It’s not that simple, because without most of these organisms we could never survive."

    As scientists map the human microbiome, they are beginning to understand the difference between normal and abnormal. Proper bacterial balance is vital to healthy immune function, providing appropriate protection against potential infections, playing a critical role in the digestion and absorption of food and nutrients, and even regulating mood. The interaction of multiple strains of bacteria is an essential element in health and wellbeing.

    The optimal balance of bacteria can be altered in many ways such as broad spectrum antibiotics that kill bacteria in the gut indiscriminately; prescription medications; disease-carrying bacteria, fungi, parasites, and yeasts; stress; lack of sleep; poor diet & lifestyle; geography and travel; and physical disconnection with nature.

    Researchers have shown that changes in gut bacteria even affect the brain and personality. For example, germ-free mice have been shown to be dramatically more anxious and hyperactive than their counterparts with a normal microbiome. These changes have also been associated with neurochemical changes in the mouse brain.

    Evidence supports the concept that microbiota balance can have a large impact on healthy metabolic processes. This delicate balance has a definite impact on nutrient acquisition and overall energy regulation.

    The impact of the gut microbiota is far reaching in the body. Continued investigation into the microbiome will yield powerful data, enabling the development of novel options to support healthy mood, metabolism, signaling molecules and much more.

    Terraflora synbiotic

    FEATURES OF TERRAFLORA

    Terraflora is a novel broad spectrum synbiotic formulated with a combination of spore form probiotics, and advanced, food-based, ancient prebiotics designed for robust support of gastrointestinal health.

    • Innovative gut microbiome support
    • Multi-strain, soil-based, beneficial bacteria to support microbial diversity in the GI tract
    • Proprietary blend of ancient, wild-harvested, certified organic prebiotic support
    • Terraflora's advanced formulation of beneficial strains and ancient prebiotics are designed to support the biodiversity reflected in ancestral diets
    • Shelf stable and requires no refrigeration
    • Highly bioavailable strains are protected by a natural seed-like structure, guarding against environmental factors and stomach acid
    • Strains effectively generate highly bioavailable riboflavin (vitamin B2) and antioxidant carotenoids, right at the sight of absorption
    • Induces anti-inflammatory effects to foster gut homeostasis
    • Supports immune health

    TERRAFLORA KEY BENEFITS

    VIABILITY – The natural seed-like structure encasing the probiotc bacteria in Terraflora™ protects them against degradation by stomach acid, so they reach their target destination — the lower GI tract — intact and alive.

    ADVANCED PREBIOTIC SUPPORT  Uniquely formulated with organic seaweeds (see reference 2 below), mushroom extracts (see reference 1 below), and humic acid (see reference 3 below). Terraflora's advanced prebiotic complex contains a diverse spectrum of naturally occurring food-based polyphenols and polysaccharides designed to support healthy intestinal flora.

    ANTIOXIDANT BENEFITS – Terraflora features Ribospore™ (Bacillus pumilus) and Bacillus megaterium EM144™, two novel probiotic strains shown in studies to produce highly bioavailable, gastric stable antioxidant carotenoids, right at the site of absorption.

    CONVENIENT — NO REFRIGERATION NECESSARY! – To ensure potency and viability, most probiotics require refrigeration and have a short shelf life. The inherently resilient bacteria in Terraflora are heat-stable, and require no refrigeration, uniting convenience and efficacy.

    WHY SOIL-BASED ORGANISMS?

    Through diet and lifestyle, our earliest ancestors were routinely exposed to spore-based bacteria found in healthy soils and our natural environment. In our modern and hyper-sanitized world, this primitive yet vital connection to nature has been all but lost.

    Soil-based organisms (SBOs) define a class of probiotic supplements based on a greater understanding of the incredible diversity of the human gut, coupled with a deeper appreciation for how humans and their commensal “helper” bacteria work together to produce a healthy system.

    Soil-based bacteria have a three-stage life cycle, with each stage triggered by nutrient availability: vegetative growth, sporulation, and germination. The sporulation phase is particularly relevant to its potential as a probiotic. The spore structure preserves the bacteria in a dormant phase and against any harm whether in any terrestrial environment or in the acidic environments of the stomach and upper intestines. When these probiotic microbiota are ingested, they travel all the way to the lower intestine where they come alive. Like a seed, warm temperatures, moisture, and nutrients stimulate the germination stage where bacteria emerges from dormancy. Soil-based probiotics are well-adapted to the environment of the gut, and have been shown to remain in the digestive tract where they can provide long term benefit.

    SBO probiotics are characterized by two traits that make them superior to other probiotics: 1) the spore phase enabling natural resistance to the harsh environment of the upper digestive tract and stomach, and 2) inherent environmental stability that does not require the addition of specialized coatings or preservatives to ensure a clinically relevant amount reaches the appropriate areas of the gut.

    Though SBO probiotics are based directly on symbiotic communities of bacteria found in natural soil environments, these organisms are not harvested directly from the earth to be packaged as a supplement. They are instead produced in a safe, monitored environment to ensure specificity of the strains.

    Why are soil-based probiotics so popular among clinicians, and what makes them so important?  The answer to this question lies in an understanding of the human gut microbiome.

    MULTI-STRAIN BACILLUS COMPLEX

    Bacteria are incredibly ubiquitous, highly adaptable ancient life forms that evolved relatively unchanged over nearly 4 billion years. Bacillus, in particular, is likely Earth’s most resilient bacteria―the oldest of which having been cultured and identified from the abdominal contents of extinct bees preserved in amber for 25 to 40 million years.

    Through diet and lifestyle, our earliest ancestors were routinely exposed to bacillus spores found in healthy soils and our natural environment. Yet we no longer have routine exposure to bacillus spores due to the hyper-sanitization of our post-industrial civilization. Terraflora’s unique probiotic + prebiotic bio-complex of commensal bacillus strains reconnect humans with their ancestral environment.

    Terraflora™ bridges the lost connection to our natural environment, with a sophisticated probiotic bio-complex of specific, commensal Bacillus strains. Selected for their unique characteristics, Bacillus are gram-positive bacteria that can exist in two forms. Under favorable conditions the bacteria grow in a vegetative form, but when starved of nutrients they differentiate into a dormant life form known as an “endospore” or simply a “spore”. These spores come alive when introduced to an ideal environment, like the human gut.

    Terraflora’s innovative DNA verified strain combination introduces Ribospore™ (Bacillus pumilus) and Bacillus megaterium EM144™, microorganisms scientifically proven to effectively produce highly bioavailable antioxidants and riboflavin, right at the site of absorption. Riboflavin is an essential nutrient for maintaining a healthy digestive tract.

    In addition to our proprietary new RibosporeTM (Bacillus pumilus) and Bacillus Megaterium EM144TM—Bacillus subtilis, Bacillus clausii, and Bacillus coagulans complete Terraflora’s multi-strain probiotic bio-complex.

    ADVANCED PREBIOTIC BIO-COMPLEX

    Terraflora™ contains a prebiotic blend of certified organic, wild-harvested seaweeds, mushroom extracts, and humic acid. These ancient, food-based prebiotics support commensal microbiota with a diverse spectrum of naturally-occurring polyphenols and polysaccharides designed to strengthen healthy intestinal flora. This bio-complex includes:

    LARCH ARABINOGALACTAN: A solvent-free water extract that retains all bioactive polyphenolic flavonoids present in Larch, including taxifolin and quercetin. Larch arabinogalactan is a densely branched, non-starch polysaccharide consisting of galactose and arabinose molecules. It has been shown to increase production of critical short-chain fatty acids (SCFAs) such as butyrate in the gut. Butyrate is the principle fuel for intestinal cells and supports healthy tight junctions in the gut lining. In addition, Larch arabinogalactan enhances beneficial gut flora and increases levels of beneficial intestinal anaerobes, particularly Bifidobacterium longum.

    FUCUS VESICULOSUS (BLADDERWRACK) & UNDARIA PINATIFIDA (WAKAME) EXTRACTS: These are certified organic solvent-free water extracts that are wild-harvested from clean ocean waters of Patagonia and Nova Scotia. They are rich in marine polyphenols and complex, sulfated, fucose-rich polysaccharides called fucoidans. Fucoidans are found in edible brown seaweeds and are shown to have multiple bioactivities including the support of healthy inflammation response in the GI tract. In vitro studies show that fucoidan effectively inhibits adhesion of pathogenic bacteria Helicobacter pylori and Escherichia coli to human cells. Furthermore, they increase the abundance of beneficial bacteria and significantly decrease inflammatory response and antigen load of the gut microbiota. In addition, they may also help maintain levels of beneficial bacteria in the gut during antibiotic use and are also known to increases the integrity of tight junctions in the gut lining.

    NORDIC CHAGA EXTRACT: This ingredient is a certified organic hot-water extract obtained exclusively from the mushroom fruiting body. It is sustainably wild-harvested in the Arctic (Finnish Lapland forest) and contains a diverse spectrum of polysaccharides and polyphenols. This extract has been shown to help protect against acute colonic inflammation and shown to decrease the Firmicutes-to-Bacteroidetes bacterial ratios. Decreased Firmicutes-to-Bacteroidetes ratios are significantly associated with lower body mass index (BMI).

    RED REISHI EXTRACT: A certified organic extract obtained by traditional hot-water extraction methods exclusively from the mushroom fruiting body. It contains a diverse spectrum of polysaccharides and polyphenols that have been shown to increase microbiota richness and regulate intestinal barrier function. It is known to support the health of the gut lumen. Furthermore, is has been shown to decrease Firmicutes-to-Bacteroidetes ratios and endotoxin-bearing Proteobacteria levels.

    HUMIC ACID: The humic acid in Terraflora™ is water extracted from ancient freshwater humate deposits. It has been shown to significantly increase the overall concentration of colonic microbiota.

    TERRAFLORA INGREDIENTS

    Probiotic Bio-Complex: 1 Billion Viable Cells per serving
    Ribosporea  (Bacillus pumilus)
    Bacillus megaterium EM144a
    Bacillus subtilis
    Bacillus clausii
    Bacillus coagulans

    
Prebiotic Bio-Complex: 850 mg per serving
    Larch Arabinogalactan (Larix spp.), Reishi (Ganoderma lucidum) Extract (fruiting body), Wild-Harvested Chaga (Inonotus obliquus) Extract (fruiting body), Wild-Harvested Nova Scotian Bladderwrack (Fucus vesiculosus) Extract (thallus), Wild-Harvested Patagonian Wakame (Undaria pinnatifida) Extract (sporophyll), Humic Acids.

    Other Ingredients: Plant cellulose (veggie capsule)

    Contains NO: dairy, wheat, yeast, gluten, corn, sugar, soy, shellfish, tree nuts, or GMOs. Made without stearates, fillers, binders, flow agents, or additives of any kind.

    DIRECTIONS

    Serving Size: Two Veggie Capsules            Servings Per Container: 30

    Suggested Use: Take 1–2 capsules per day with or without food, or as recommended by your health care professional.

    If you are pregnant, nursing, or have a medical condition, consult your healthcare practitioner before use.

    REFERENCES

    1. Article regarding the use of mushroom extracts as prebiotics:

      A Critical Review on Health Promoting Benefits of Edible Mushrooms through Gut Microbiota
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618583/

      Abstract
      Mushrooms have long been used for medicinal and food purposes for over a thousand years, but a complete elucidation of the health-promoting properties of mushrooms through regulating gut microbiota has not yet been fully exploited. Mushrooms comprise a vast, and yet largely untapped, source of powerful new pharmaceutical substances. Mushrooms have been used in health care for treating simple and common diseases, like skin diseases and pandemic diseases like AIDS. This review is aimed at accumulating the health-promoting benefits of edible mushrooms through gut microbiota. Mushrooms are proven to possess anti-allergic, anti-cholesterol, anti-tumor, and anti-cancer properties. Mushrooms are rich in carbohydrates, like chitin, hemicellulose, β and α-glucans, mannans, xylans, and galactans, which make them the right choice for prebiotics. Mushrooms act as a prebiotics to stimulate the growth of gut microbiota, conferring health benefits to the host. In the present review, we have summarized the beneficial activities of various mushrooms on gut microbiota via the inhibition of exogenous pathogens and, thus, improving the host health.

      2. Article regarding the use of seaweeds as prebiotics:
      Prebiotics from Marine Macroalgae [seaweeds] for Human and Animal Health Applications
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920542/

      Abstract
      The marine environment is an untapped source of bioactive compounds. Specifically, marine macroalgae (seaweeds) are rich in polysaccharides that could potentially be exploited as prebiotic functional ingredients for both human and animal health applications. Prebiotics are non-digestible, selectively fermented compounds that stimulate the growth and/or activity of beneficial gut microbiota which, in turn, confer health benefits on the host. This review will introduce the concept and potential applications of prebiotics, followed by an outline of the chemistry of seaweed polysaccharides. Their potential for use as prebiotics for both humans and animals will be highlighted by reviewing data from both in vitro and in vivo studies conducted to date.

      3. Article regarding the use of humic acids as prebiotics:
      Impact of humic acids oun the colonic microbiome in healthy volunteers
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920542/

      Abstract
      AIM: To test the effects of humic acids on innate microbial communities of the colon.
      METHODS: We followed the effects of oral supplementation with humic acids (Activomin®) on concentrations and composition of colonic microbiome in 14 healthy volunteers for 45 d. 3 × 800 mg Activomin® were taken orally for 10 d followed by 3 × 400 mg for 35 d. Colonic microbiota were investigated using multicolor fluorescence in situ hybridization (FISH) of Carnoy fixated and paraffin embedded stool cylinders. Two stool samples were collected a week prior to therapy and one stool sample on days 10, 31 and 45. Forty-one FISH probes representing different bacterial groups were used.
      RESULTS: The sum concentration of colonic microbiota increased from 20% at day 10 to 30% by day 31 and remained stable until day 45 (32%) of humic acid supplementation (P < 0.001). The increase in the concentrations in each person was due to growth of preexisting groups. The individual microbial profile of the patients remained unchanged. Similarly, the bacterial diversity remained stable. Concentrations of 24 of the 35 substantial groups increased from 20% to 96%. Two bacterial groups detected with Bac303 (Bacteroides) and Myc657 (mycolic acid-containing Actinomycetes) FISH probes decreased (P > 0.05). The others remained unaffected. Bacterial groups with initially marginal concentrations (< 0.1 × 109/mL) demonstrated no response to humic acids. The concentrations of pioneer groups of Bifidobacteriaceae, Enterobacteriaceae and Clostridium difficile increased but the observed differences were statistically not significant.
      CONCLUSION: Humic acids have a profound effect on healthy colonic microbiome and may be potentially interesting substances for the development of drugs that control the innate colonic microbiome.

  • WARRIOR MIST TOPICAL FOR PAIN RELIEF

    Fred Liers PhD warrior mist topical pain relieverWarrior Mist™ is the most effective formula for pain relief offered by HPDI. Warrior Mist is an all-natural, fast-acting, topical pain reliever that is effective for many types of pain. I should know. I have used it nearly every day—for years!

    Types of pain Warrior Mist is known to stop, reduce, or soothe include: back pain (including sciatica), knee pain, carpal tunnel syndrome, headaches (including migraines), neck pain and tension, stiff and painful (or pulled) muscles, plantar fascitis, arthritis, sports injuries, old injuries, sprains and strains, bruises (including deep bruises), shin splints, tennis elbow, nerve pain, and post surgery pain.

    Practicing aikido for years, I have a frequent need for the rapid effects of Warrior Mist. Having used it for regularly for a long time, I appreciate how quickly it relieves pain like joint pain or sprains. It also works spectacularly for bruises, cuts, abrasions, burns, bug bites, and many other applications.

    TESTIMONIAL: "This really works. I had tried several other products, including prescription medications, and little success. There was a noticeable difference after my first use of the product." – Amazon customer

    Warrior Mist comes in a convenient one-ounce spray bottle. I shake the bottle and then add a few pumps—or as many as I need—to my non-pumping hand and rub onto the affected area. You can also spray it directly onto skin before rubbing it in with a clean hand. If you need more, you can always unscrew the cap and pour directly into your hand or onto skin, but I usually only reserve this action for times when I'm at the end of the bottle and I want to use all the Warrior Mist remaining in the bottle.

    The small bottle travels well, and I usually take it with me whenever I travel. I also keep a bottle ready in a small hiking kit that I carry with me on the trail. While I may not always need it, nevertheless it is there. I cannot count how often I used it when I've least expected to need it. Sprained ankles or swollen fingers heal a lot faster than you might expect, compared to not having Warrior Mist around. It even works well on things like mosquito bites—and helps repel them.

    Warrior Mist can be combined effectively with other natural topical products, especially Ancient Minerals Magnesium Oil (see video). I often mix a little Warrior Mist with Magnesium Oil in my palm. This mix gives me all the benefits of Warrior Mist with the added boost of extra magnesium chloride that speeds healing.

    Warrior Mist pain relief formula

    WARRIOR MIST BENEFITS

    Warrior Mist offers rapid pain relief and many other benefits:

    • RAPID, EFFECTIVE PAIN RELIEF – Formulated as a fast-acting pain reliever using only natural ingredients

    • LONG LASTING – pain relief last eight hours (or more) per use. This is a natural formula, so you will eventually need to re-apply it. But fewer applications means more time living life pain free.

    • SAFE – 100% natural formula. This means that unlike prescription drugs or many over-the-counter medicines, there are no harsh or dangerous side effects.

    • RAPID HEALING. Not only effectively relieves pain, but also supports rapid healing at the cellular level. It thereby supports healing at the sources of pain. i.e., helps with the underlying causes of pain.

    • REDUCES MUSCLE SORENESS AND TENSION. Another benefit of direct topical application of natural, yet powerful (mostly herbal) ingredients. While this has obvious benefits for athletes, it also helps weekend warriors, or anyone who has muscle soreness due to any reason!

    • INCREASES CIRCULATION. Increased circulation is a significant healthy benefit in itself, allowing better oxygenation of tissues, supporting healing, reducing stagnation of blood, and boosting processes of detoxification.

    • LESSENS INFLAMMATION. Inflamatory processes can be harmful to the body. Warrior Mist helps reduce inflammation naturally, and thereby lessens free-radical damage from it, for example. This significantly supports your healing process.

    • TISSUE REPAIR. When the ingredients in Warrior Mist penetrate tissues, then those tissues can begin the process of healing and repair, and do it faster!

    • HEALS SKIN IRRITATIONS. A major added benefit is the healing of "minor" skin irritations, cuts, abrasions, etc. This is because the ingredients in Warrior Mist™ do double duty as superb nutrients for the skin.

    • SCAR REDUCTION. Warrior Mist™ can soften scar tissues and stimulate the kind of deep healing that results in smaller scars and improved appearance of scars.

    TESTIMONIAL: "Warrior Mist is the only product that I have found which truly relieves the osteoarthritis pain in my knee!! I am amazed by the speed and effectiveness of Warrior Mist. As an older person who has planned and worked to be able to complete my life in my own home, Warrior Mist contributes enormously to my ability to do that! Thank you for this excellent product!" – Amazon customer

     

    WHY IS WARRIOR MIST EFFECTIVE?

    Warrior Mist™ is a revolutionary skin, muscle, and joint support formula that uses DMSO, olive oil, coconut oil, and water as base (or carrier) ingredients that transdermally transport the other ingredients directly to the site of the problem where they work together harmoniously and effectively.

    Functional ingredients carried to the site of pain include: peppermint oil (the primary source of menthol in the product), magnesium chloride, MSM, lemon oil, and lavender oil. Each of the functional ingredients (and their amounts) were carefully selected for their ability to stop pain, to help the body overcome the causes of pain, to promote healing at the local level, or to work synergistically with the other ingredients. Warrior Mist is 100% all-natural and totally safe!

    As a topical analgesic, Warrior Mist conforms to the proposed rules set forth in FDA Monograph 348. The label used on the current Warrior Mist (1 oz spray bottle) meets the requirements set forth in this monograph. Even though there are a number of ingredients in Warrior Mist that can potentially provide temporary pain relief, the FDA monograph only recognizes the ingredient menthol, the major ingredient in peppermint oil, as an allowable active ingredient. According to the monograph, we can only mention menthol as the active ingredient and all other ingredients must be labelled as inactive ingredients.

    The truth is that all the ingredients (functional and base/carrier ingredients) add up to a synergistic formula that rapidly relieves pain in a single, easy-to-apply topical product. What more could you ask for?

    WHAT INGREDIENTS DOES WARRIOR MIST CONTAIN?

    COMPOSITION / INGREDIENTS: DMSO (99.999% pure), peppermint oil, organic olive oil, distilled water, MSM, magnesium chloride, lemon oil, lavender oil, and organic coconut oil.

    DMSO
    Dimethyl sulfoxide (DMSO), a by-product of the wood industry, has been in use as a commercial solvent since 1953. Furthermore, in 125 countries throughout the world doctors prescribe it for a variety of issues, including inflammation. DMSO has been used widely as a carrier in topical analgesic formulas. Laboratory studies have shown that DMSO is able to block peripheral nerve C fibers.

    Burns, cuts, and sprains have been treated with DMSO. Relief is reported to be almost immediate, lasting up to 6 hours. DMSO reduces inflammation by several mechanisms. It is an antioxidant, a scavenger of the free radicals that gather at the site of injury. Studies have shown DMSO to be one of the safest ingredients known with a toxicity similar to that of water.

    DMSO has long been used to promote healing both in animals and humans. Those who have used it for minor cuts and burns report that recovery is speedy. Several studies have documented DMSO use with soft tissue damage, local tissue death, skin ulcers, and burns. Applied topically and repeatedly, DMSO flattens the raised, nodular, lobed liner mass of scar tissue in keloids and acne.

    MSM
    MSM is a naturally occurring nutrient found in normal human diets. In the body DMSO and MSM, which form each other, are indistinguishable in their biochemical effects. They reach a equilibrium distribution between them that is dependent on the local body chemistry, and is independent of which one you start with. The metabolic enhancement mechanism of MSM and DMSO is that of an exceptionally effective oxygen transport system. This system is made particularly effective by the feature that both DMSO and MSM are highly soluble in both oil and water.

    MSM makes cell walls permeable, allowing water and nutrients to freely flow into cells and allowing wastes and toxins to properly flow out. The body uses MSM along with Vitamin C to create new healthy cells, and MSM provides the flexible bond between the cells. Without proper levels of MSM, our bodies are unable to build healthy cells, and this leads to problems such as lost flexibility, scar tissue, wrinkles, varicose veins, hardened arteries, damaged lung tissues, dry cracking skin, digestive disorders, joint problems, and inability to defend against allergic reactions to food, animals and plants.

    The applications of MSM include pain control (analgesic), inflammation control, dilation of blood vessels, increased blood flow, reduced muscle spasm, altering the crosslinking process in collagen (e.g., reducing scar tissue,) anti-parasitic effects (particularly against Giardia), and immune normalizing effects. MSM has a unique ability to pass through cellular membranes (including skin).

    Peppermint Oil
    The primary constituent of peppermint oil is menthol, which causes a physical reaction when inhaled or applied to the skin. Menthol produces an immediate and pronounced sensation of coolness that effects the body quite noticeably, and creates a "warming effect" as blood flows into the area of application.

    Peppermint oil can be used externally for providing relief from pain. Peppermint oil increases your immunity. It also improves blood circulation. Additional of the uses of peppermint oil include:acne, asthma, colds, cramps, dermatitis, exhaustion, influenza, headache, insect bites, mental fatigue, migraine, nausea, nerve pain, neuralgia, poor circulation, and respiratory disorders.

    Lavender Oil
    Lavender oil helps in treating migraines, headaches, anxiety, depression, nervous tension and emotional stress. The refreshing aroma removes nervous exhaustion and restlessness and increases mental activity. Because it induces sleep, it is often recommended for insomnia. Lavender oil is also an excellent remedy for various types of pains including those caused by sore muscles, tense muscles, muscular aches, rheumatism, sprains, backache,and lumbago. A regular massage with lavender oil can provide relief from pain in the joints.

    Lavender oil is also good for improving blood circulation in the body. The health benefits of lavender oil for the skin can be attributed to its antiseptic and antifungal properties. It is used to treat various skin conditions, including acne, wrinkles, psoriasis, and other inflammatory conditions. It heals wounds, cuts, burns, and sunburns rapidly because it aids in the formation of scar tissues. It is also effective against insect bites. The oil also repels mosquitoes and moths.

    Lemon Oil
    Lemon oil is powerfully astringent and antiseptic. Lemon oil is detoxifying and is therefore good for blemishes associated with oily skin. Lemon oil is a powerful antioxidant and is a tonic for supporting the nervous and sympathetic nervous system. It's been long known that lemon oil is anti-infective, antibacterial (especially with spores), and antiviral. It can function as a disinfectant and exerts vitamin P-like action for improving microcirculation, promotes white blood cell formation, and improves immune function. It has also been widely used in skin care to cleanse skin and reduce wrinkles.

    Magnesium Chloride
    Magnesium chloride applied to the skin is an effective means for increasing magnesium levels in the body, and is particularly useful for relieving sore muscles and joints, and reducing pain related to functional magnesium deficiency. It is also proven for use in helping to calm “nerves” and reduce systemic bodily stress. Because the magnesium targets muscle tissues, it is thereby especially useful for replenishing depleted soft tissues and helping restore proper function.

    Magnesium is necessary for the production of energy in the body. When the body receives adequate amounts of magnesium, it can produce the levels of energy required to sustain the body and enable it to thrive. Magnesium chloride is proven for use in a variety of general applications, including bruises, cramps, muscle tension, and migraine headaches.

    Olive Oil
    Used as a base and mixed with other essential oils, olive oil makes a wonderful oil for skin health. In fact, it has been touted as one of the oldest healing and beauty techniques. A biblical reference from about 493 BCE documents the daily massage with olive oil and other oils as a part of the beauty regimen.

    Coconut Oil
    Coconut oil is a superb skin lotion because it both nourishes skin and is naturally anti-bacterial, antiviral, and antifungal due to its high content of medium chain triglycerides

    DIRECTIONS: Shake bottle before applying. Wash hands before and after use. Apply in a thin layer to a clean, dry, and lotion-free area needing support. Shave thick hair that may prevent absorption by the skin. Gently massage the area of application to assist absorption. Reapply as needed 3–4 times daily. Contains DMSO, a known solvent. Use on people or pets at your own discretion.

    USES: Warrior Mist™ is an all-natural skin, muscle, and joint support formula.

    WARNINGS: For external use only. May cause temporary (up to 45 minutes) skin irritation, heating, or flushing upon use. Discontinue use if temporary skin conditions persist. Do not use on wounds or severely damaged skin. Do not bandage tightly. Avoid contact with eyes. Flush eyes with cool water if exposed. Do not use if allergic to any ingredients. Stop use and visit a health care professional if reason for use continues for more than one week. If swallowed get medical help or call a Poison Control Center. Consult a health care professional before use if pregnant.

    Warrior Mist topical pain formula

    CONCLUSION

    Warrior Mist topical formula is highly effective for pain relief. A major advantage is that it is a natural formula (available without a prescription) and can safely be re-applied whenever necessary. Another benefit is that it lacks the side effects common to prescription pain medications.

    Try Warrior Mist for yourself. If you're like me, you will want to keep a bottle or two ready for the aches and pains of daily life. Use it as often as you need it. Be a warrior!

    RESOURCES

    PRODUCTS

    Warrior Mist

    Ancient Minerals Magnesium Oil

    Ancient Minerals Magnesium Oil, Flakes, Gel, Lotion

    Warrior Health Products

    Creams, Salves, and Topical Formulas

     Topical Formulas

    BLOG ARTICLES

    Effective Pain Relief Strategies with Warrior Mist

    Warrior Mist: Creating an Amazing Pain Relief Formula

    Super Remedies for Stings and Bites

  • ESSENTIAL NUTRIENTS – SEVEN ARGUMENTS FOR NUTRITIONAL SUPPLEMENTS

    Fred Liers PhD nutrients nutritional supplementsAlmost daily articles, reports, or studies appear claiming nutritional supplements are not effective. The claims vary, but the verdict is always there is little or no scientific evidence proving supplements (or the nutrients in supplements) work. Others assert that people who take supplements have the world's most expensive urine. This is nonsense! The scientific evidence is clear, available, and it has been for a long time.

    Among the many problems with these reports is bashing supplements based on studies using low dose or non-therapeutic levels of nutrients. There is frequently failure to consider the importance of synergy among nutrients. Often there is data manipulation via statistical methods (often in meta-analyses).

    Well beyond the question of whether supplements support health are the factors in modern life that create a greater needs for supplementing with important vitamins, minerals, cofactors, and other nutrients.

    This month we present "Seven Arguments for Nutritional Supplements." As the title implies, there are at least seven solid arguments for nutritional supplementation. There are actually a lot more.

    To preview these arguments in favor of taking supplements, they are: 1) reduced food quality, 2) nutrient density varies by location, 3) modern lifestyles and stress, 4) environmental pollution, 5) too low RDAs, and 6) promotion of health and delaying of aging, and 7) the human right to correct information.

    essential nutrients fatty acids EFA supplement Essential Fatty Acids (EFA) are one type of essential nutrient required for health.

    We at HPDI re-publish articles from the Orthomolecular News Service  (OMNS) because the authors provide much needed truth. Truth the form of correcting the false assumptions of anti-supplement propagandists to clarify the benefits of nutritional supplements. This information can help people be healthier easily and at relatively low cost.

    HPDI offers a full line of foundational nutritional supplements, including multivitamins, vitamin C and antioxidant formulas, essential fats, and high-RNA Rejuvenate! superfoods. We also offer nearly 100 other nutritional supplements from single nutrients to condition specific formulas. See our full product overview.

    Enjoy this article from the Orthomolecular News Service (OMNS). ~

    Seven Arguments for Taking Nutritional Supplements

    by Dag Viljen Poleszynski, PhD

    (OMNS Sept 12 2018)

    One of the most vitamin-restrictive countries in the world is Norway. There, authorities limit potencies to only slightly higher than RDA (Recommended Dietary Allowance) levels for dietary supplements sold outside of pharmacies. The traditional reasoning is that most people receive the nutrients they need from a "balanced diet." [1]

    The authorities are also obsessively concerned that some vitamins and minerals are harmful in high doses. And, since an intake of water-soluble vitamins in excess of needs is excreted in the urine, Norwegian "experts" advise that taking supplements is a waste of money.

    Accordingly, the argument goes, the public should be protected not only from possible harm, but also from wasting money on unnecessary nutrients. The official policies on nutritional supplements vary within OECD (Organization for Economic Cooperation and Development) countries. Some are more liberal, while others are even more restrictive.

    The official view on the connection between nutrient intake and possible toxicity is illustrated by the Norwegian Food Authority in a graph. [2]

    Perceived risk from intake of nutrients. (Source: Expert Group on Vitamins and Minerals. Safe upper limits for Vitamins and Minerals. May 2003: Food Standards Agency, UK.)

    The graph illustrates the official view on nutrients, assuming that nutrients function in the same way as pharmaceuticals, which they do not. Supplements of most vitamins, but also minerals and other nutrients, do not have very serious side effects even when taken at very high levels - in contrast with most drugs. [3,4] The fact that most of the chemotherapeutic drugs used against cancer have none or even just marginal effects against most cancers [5], while at the same time cause a lot of serious side effects, is rarely up for discussion.

    The idea that nutritional supplements are not safe has a legal underpinning in Norwegian Food Law, which in section 16 prohibits sale of any food which is not safe: "Any food shall be considered not to be safe if it is seen as detrimental to health or not fit for consumption." [6]

    However, the Norwegian authorities do admit that vitamin D supplements are needed during part of the year. [1] Only part of the year? One third of Norway is within the Arctic Circle. Norway has far too little sunshine (especially during winter months) to get adequate levels of vitamin D from UVB radiation on the skin.

    The authorities also recommend that pregnant women take folic acid to prevent birth defects, and omega-3-fatty acids may be advisable for those who do not eat fish regularly. Norwegians have a long tradition of giving children cod liver oil, which in a daily tablespoon provides enough vitamin A and D and essential fatty acids to cover basic needs.

    Essential and conditionally essential nutrients

    There are thousands of dietary supplements on the market, including 40+ essential nutrients alone and in various combinations, i.e. vitamins, minerals, trace elements and fatty acids. However, a number of other nutrients are "conditionally essential", meaning that the body normally can make these molecules, but some people do not make optimal amounts. Examples are L-carnitine, alpha-lipoic acid, the methyl donor betaine, [7] chondroitin sulfate, coenzyme Q10, choline, amino acids such as tyrosine or arginine, and "essential" sugars normally formed in the body. [8]

    Healthy young people normally make sufficient amounts of conditionally essential molecules in the body, although the levels are not always optimal. With inadequate levels of minerals or vitamins, key enzymes in biochemical pathways may not function optimally.

    Due to genetic mutations, some enzymes may have increased needs for certain cofactors (vitamins), which can prevent them from functioning optimally.[9] Some enzymes only function normally when supplied with cofactors in greater amounts than normally required.

    If supplements of essential nutrients prove insufficient for optimal enzyme function, "conditionally essential" nutrients may be added as part of a comprehensive, therapeutic program.

    Some reservations

    Parents are advised to become familiar with the literature on essential nutrients, for instance by consulting the Orthomolecular News Service. Children should be given supplements in appropriate doses and in a suitable form. Pills should not be given before children can control the swallowing reflex. Multivitamin powder can be given dissolved in water or juice. Parents should not dose vitamin C so high that a child comes to school or kindergarten with loose bowels or diarrhea.

    In high doses, niacin may cause unpleasant side effects such as flushing and itching lasting up to several hours. [10] Although this is not dangerous, it may cause a child to feel unwell and anxious. Starting niacin supplementation with a low dose and gradually increasing it will allow the body to adapt and avoid the niacin flush.

    A multivitamin supplement containing moderate amounts of niacin is often adequate until a child is 8-10 years old. For younger children, the dosage should start with only a few tens of milligrams, and not increased to more than 50-100 mg/day. Adults may gradually get used to taking 1,000-1,500 mg/d divided into 3 doses per day.

    When it comes to omega-3 fatty acids (omega = ω) such as EPA and DHA, children may be given cod liver oil and served fish and/or other seafood 2-3 times a week. It is important to check the dose of vitamin A supplied, as it can be toxic in high doses, especially for children. One problem with cod liver oil today is that vitamin D has been removed during processing, thus changing the natural ratio of the two vitamins so that we ingest relatively too much of vitamin A. [11]

    Higher dosages may be given after having consulted a therapist who has measured the ratio of omega-6 to omega-3 fatty acids in relevant cell membranes (red blood cells). In most industrialized countries, many people get too much of the omega-6 fatty acids, and would therefore benefit from eating more seafood or taking supplements with omega-3 fatty acids derived from organisms low in the food chain (algae, krill).

    Flax seeds contain a high level of the essential omega-3 fatty acid alpha-linolenic acid, and freshly ground flaxseed meal or flax oil can be mixed with breakfast cereals or smoothies. Note that it may be advisable to limit eating farmed fish to once per week, since their fodder contains less omega-3 fatty acids than the food eaten by wild fish, and possibly also contains more contaminants. [12] Some researchers even warn against letting children eat too much fish because of the content of environmental toxins. [13,14]

    Reasons for high-dose supplements of micronutrients

    I have identified a number of arguments in favor of supplementing the modern diet with essential nutrients, here summarized with seven headlines. Most people should consider taking a multivitamin supplement containing vitamins and minerals even if they eat a nutritionally balanced diet.

    Additional nutrients may contribute to better health and, in some cases, can be of vital importance in our modern world. The arguments are presented in random order, i.e. the order does not reflect priority.

    1. The agricultural revolution has reduced food quality

    The transition from an existence as hunter and gatherers to urban agriculture around 10,000 years ago began an epoch when foods were mass-produced but had lower nutritional density, compared with the previous food eaten by our ancestors. The nutritional density in many foods has fallen significantly since human societies transformed from hunter-gatherers into resident farmers. This is especially true in the last 60-70 years after agriculture was changed from small, versatile ecologically driven family farms to large, chemical-based, industrial agriculture. [15]

    The reduction of nutritional content in modern crops, compared with older varieties, is well documented. [16] It is a consequence of soil erosion, loss of essential minerals from continual heavy use, combined with breeding of new varieties, which has increased the size and growth rate of plants by increasing the content of sugar and water and decreasing their mineral content compared to ancient species. At the same time, the relative content of other macronutrients (fat, protein/amino acids) and antioxidants may have been reduced.

    Reduced nutritional density in many foods, combined with the use of refined "foods" like sugar, white flour and refined oils, places a greater priority on eating the most nutritious foods.

    Farm produce grown organically generally has higher levels of essential nutrients such as trace minerals because the soil contains higher levels of trace minerals and the produce grows slower and thus has more time to absorb nutrients from the soil. Examples of nutrient dense foods are sardines, wild salmon, shellfish, eggs, liver, kale, collards and spinach, sea plants (seaweed), garlic, blueberries, and dark chocolate. [17]

    2. Nutritional content of food varies with geographical location

    Nutritional density varies considerably geographically between different regions, even with the same agricultural methods. This was documented in the United States in 1948 by a researcher at Rutgers University in the so-called Firman Bear report. [18] At that time agriculture was little mechanized, and artificial fertilizers and pesticides were hardly used.

    The analysis found large differences in the content of minerals in the same food. The largest variations were found for potassium, sodium, boron and iron in spinach, while the greatest differences in calcium, magnesium and copper content were found in tomatoes.

    The soil in areas with relatively low rainfall may in some cases contain an extremely high concentration of minerals, which is reflected in the plants growing there. This was well documented 70 years ago in the book Tomorrow's Food. [19] The dentist George W. Heard found that the soil in Hereford, Texas, was exceptionally rich in minerals.[20]

    Hereford became known as the "town without a toothache" after a newspaper article from January 29, 1942, reported that Hereford had the lowest incidence of tooth decay of any city in the United States. [21] Dr. Heard found that people in Hereford had exceptionally few dental cavities and also that the soil locally was especially rich in minerals. He emphasized that the population in the county ate unprocessed food and was drinking raw milk. [19]

    Recent research shows that differences in the content of the selenium in the soil can cause major differences in the concentration of selenium in meat. [22] For instance, since the soil in Finland is poor in selenium, the authorities decided in the early 1980s to add selenate to commercial fertilizers. A survey of selenium status among 108 healthy young people showed an increase in the blood selenium level of about 50 percent after four years. [23]

    A similar problem with the level of minerals in the soil exists for the content of magnesium. Often when the soil gets depleted of magnesium from heavy use, this essential mineral is not included in soil amendment with fertilizers. Produce grown in soil with an adequate level of magnesium will contain more magnesium than produce grown in soil deficient in magnesium.

    Perhaps as many as 70-80% of the US population is magnesium-deficient, which causes many health problems. [24] Magnesium supplements (chloride, malate or citrate) can provide an adequate level when vegetables grown in soil with adequate magnesium are not available.

    3. Stress and the modern lifestyle increase the need for nutrients

    Mental stress increases the excretion and hence the need for many nutrients. Among the most important are magnesium and vitamin C, both of which are used by the body in larger quantities during periods of physical and mental stress. [24,25] Compared with our past as hunters and gatherers, today´s stress is often of a more permanent nature. Instead of experiencing occasional situations where we had to fight or flee, many of us live with recurring stress day in and out.

    Vitamin C protects the brain and nervous system from damage caused by stress because the synthesis and maintenance of chemical neurotransmitters such as adrenaline and noradrenaline requires adequate levels of vitamin C. [25]

    Vitamin C is also needed to repair collagen which is essential for skin, blood vessels, bones and joints, and muscles. When these are damaged by physical stress, extra vitamin C is necessary.

    A controlled trial of 91 adults who experienced increased anxiety and stress 2-3 months after an earthquake in New Zealand in 2011 was divided into three groups, two were given a broad spectrum supplement of micronutrients in low or higher doses. [26] The supplements were found to alleviate the experience of stress, with the biggest dose having the biggest effect.

    Our sedate, modern lifestyle reduces the need for energy from food, which implies a lower food intake or obesity. Loren Cordain, PhD, and coworkers have estimated that hunter-gatherers had significantly higher energy needs than the typical modern office worker. [27]

    A lower energy intake generally reduces the absolute intake of all nutrients, while the need for some nutrients is not always reduced proportionally with energy intake. Overall this suggests that more exercise along with a more nutritious diet, including supplements of essential nutrients and less carbohydrates, will help to prevent obesity and maintain health.

    Processing of food reduces its nutritional content, and the finished products are often based on fractions of the original foods. One example is milling grain to make white flour, [1] which has a lower nutritional density than whole grain flour.

    The reduction in nutritional value has accelerated since whole foods are now divided into pieces, for example, boneless chicken breast. When meat is injected with saline to increase the volume, the relative level of essential nutrients is reduced. In the United States, many supermarkets in low-income rural and inner city areas have a limited selection of nutrient-dense foods, compared with high-income areas. [28]

    4. Environmental pollutants increase the need for nutrients

    The need for efficient detoxification and excretion is greatly increased by environmental pollution from the chemical industry, herbicides and pesticides used by industrial agriculture, antibiotic treatment of animals, transport, and plastic packaging. [29]

    In our polluted world, the increased toxic load may be compensated for by an increase in nutrients to promote detoxification. One can respond by taking large doses of supplements of essential nutrients, for example, antioxidants vitamin C and E, and an adequate dose of selenium, which help the body detoxify harmful chemicals. Also helpful is regularly taking sauna baths, fasting periodically, and eating an excellent diet that includes generous portions of dark green leafy vegetables and colorful vegetables and fruits. [30]

    A recent study predicts that global warming may reduce the nutrient density in many foods worldwide. [31] Atmospheric CO2 is estimated to surpass 550 ppm in the next 30-80 years, leading to larger crops with lower content of protein, iron and zinc per energy unit.

    Assuming that diets remain constant, while excluding other climate impacts on food production, the researchers estimated that elevated CO2 could cause an additional 175 million people to be zinc deficient and an additional 122 million people to be protein deficient in 2050. Anemia would increase significantly if crops lose even a small amount of iron. The highest risk regions - South and Southeast Asia, Africa, and the Middle East - are especially vulnerable, since they do not have the means and access to compensate using nutritional supplements.

    5. The RDA for essential nutrients is too low

    The recommended nutrient reference intake (NRI) has been defined by UK authorities and the EU Food Safety Agency as the dose that is adequate for 95 percent of the population. [32] These authorities have given recommendations for a total of 41 chemical substances, [33] including 13 vitamins, 17 minerals/trace elements, 9 amino acids and two fatty acids. The problem with such guidelines is that when using the same 0.95 fraction for just 16 of the essential nutrients, the fraction of the overall population that has their needs met with the RDA is less than half (0.9516 = 0.44).

    Given the above assumption, the proportion of the population having all nutrient needs met falls below 25 percent for 30 nutrients (0.9530 = 0.21). These 25 percent will not necessarily get optimal amounts, just enough so that they probably will have no deficiencies in accordance with established standards. Each individual is different and has different biochemical needs, so we all need different doses of essential nutrients. Many vitamins and minerals can give additional benefit when taken at higher doses.

    The need for several essential nutrients increases with age and sickness. This applies, for example, to vitamin C, vitamin D, magnesium, and iron. In 2017 the Norwegian Food Safety Authority proposed to revise the official maximum levels for vitamins and minerals in dietary supplements. [34]

    Their proposal introduced four different age categories with separate maximum intakes. Initially, the agencies proposed to revise the daily doses allowed in dietary supplements for folic acid, magnesium, calcium, vitamin C and D. At the same time, maximum rates were temporarily suspended for vitamins A, E, K, thiamine (B1), riboflavin (B2), niacin (B3), pantothenate (B5), pyridoxine (B6), cobalamine (B12), biotin, and for phosphorus, iron, copper, iodine, zinc, manganese, selenium, chromium, molybdenum, sodium, potassium, fluoride, chloride, boron and silicon.

    The upper limits for some nutrients may be changed in the future. Unfortunately, Norwegian nutrition "experts" will likely continue to limit allowable doses below those freely available in the US and even Sweden.

    6. An optimal nutrient intake promotes health and delays aging

    A spokesperson for optimal nutritional intake is the well-known biochemist Bruce Ames, who proposed the "triage theory of nutrients," in which enzymes responsible for cell maintenance functions evolved to have lower affinity for the essential vitamin and mineral cofactors than the enzymes responsible for short-term survival, to preserve life during times of famine. [35]

    Thus, higher levels of vitamins and minerals may delay mitochondrial aging, speed up the repair of large molecules such as DNA and collagen, and generally improve other cellular functions. This is an important rationale for taking higher doses of vitamins and minerals than recommended reference intakes.

    Dietary supplements can slow the aging process, in part by reducing the harmful effects of free radicals, known to be involved in many diseases such as cardiovascular disease and cancer. [36]

    Naturally occurring hormones and/or supplements of cofactors needed for optimal hormone production in the body can have a significant life-prolonging effect if the body produces less than optimal amounts. [37] This is especially relevant for those with a genetic predisposition for disease.

    An optimum intake of all nutrients is difficult to achieve even for those who eat almost exclusively an excellent diet of nutrient dense foods, such as meat and innards, fish, shellfish, fowl, eggs, nuts, mushrooms, and vegetables, berries and nutritious fruits. Some nutrients such as folic acid or carotenoids in vegetables are absorbed better from processed than unprocessed foods.

    Although vegetables are often considered to be a good source of vitamins, for example vitamin A from carrots, vitamin A is only found in animal products such as liver, egg yolk, fish cod and cod liver oil. Although eating raw vegetables is helpful for several reasons (vitamin C, fiber, microbiota), carotenoids (alpha/beta-carotene, lutein, lycopene) in vegetables are less well absorbed from raw than cooked food and better absorbed in the presence of added fat. [38,39].

    Nutrients in vegetables are better absorbed when finely chewed, graded, or mashed [38], and cooking and grinding meat reduces the energy required to digest it [40] and increases nutrient absorption [41].

    Orthomolecular pioneer Abram Hoffer and Orthomolecular News Service Editor Andrew W. Saul suggested this list of daily intakes of vitamins and minerals. [42] The Norwegian 2017 recommendations for adult men and women [43] are given in comparison. Individual needs may vary substantially from person to person and also with health status.

    The figures for optimal intake are obtained from the Independent Vitamin Safety Review Panel of physicians, researchers and academics, who concluded:

    "People are deceived in believing that they can get all the nutrients they need from a 'balanced diet' consisting of processed foods. To achieve an adequate intake of vitamins and minerals, a diet of unprocessed whole foods, along with intelligent use of dietary supplements is more than just a good idea: it is vital." [44: 55]

    A well-known example is vitamin C, which can effectively fight viral infections, prevent or reverse disease caused by bacteria, and help the body detoxify organic and inorganic toxins. [45] Vitamin C also reduces the risk for cancer, strengthens connective tissues (collagen), and counteracts stress by increasing the adrenal´s production of cortisol. The dose required is set according to the body's need.

    Nobel Price Laureate Linus Pauling suggested that an optimal daily intake of vitamin C could vary from at least 250 mg up to 20 grams per day. [46] Because unabsorbed vitamin C attracts water into the gut, some people may experience loose stools, gas and/or diarrhea by ingesting only 1-2 grams at a time, while others with a higher level of stress may tolerate 5-6 grams or more. The dose that causes loose stools is called the "bowel tolerance" for vitamin C. [47] To avoid the laxative effect of high doses, it is best to take vitamin C throughout the day in smaller divided doses.

    When the body is stressed by disease, the gut will naturally absorb more vitamin C because the body needs more. To find the optimal dose, the intake should be increased until bowel tolerance is reached. Some people can tolerate more than 100,000 mg/d of vitamin C in divided doses during serious illness without having loose stool.

    Liposomal vitamin C bypasses the normal bowel tolerance because it is absorbed directly through cell membranes, so higher doses can be tolerated without diarrhea.

    7. A human right to receive correct information

    Access to correct information about food and essential nutrients, including knowledge about the importance of food for health is a fundamental human right. Such information should not only provide a summary of the nutrient content of food, but in our opinion should also explain how dietary supplements can counteract deficiencies and prevent and reverse disease caused by nutrient deficiencies.

    We should be free to purchase quality-controlled supplements of essential nutrients and to use them to counteract aging and damage from stress as part of a long-term health plan. The right to reject recommendations by doctors for symptomatic treatment with synthetic, some times life-threatening, drugs to alleviate symptoms should be included. [48,49]

    I have not found any formulation of such rights from the Norwegian authorities. The role of parents and their right to receive correct health information is addressed in a book by lawyer Anne Kjersti C. Befring, a fellow at the University of Oslo since 2014. [50]

    Summary

    The use of dietary supplements is widespread. High doses of vitamins are thought to be helpful because they help the body recover from damage and maintain itself long-term. Many vitamins are not harmful in doses even 10 to 100-fold higher than officially recommended.

    Some governments warn about possible negative side effects, even including increased mortality from "excessive" intake of certain supplements. However, supplements of essential nutrients have been available for more than 80 years. They are known to be safe, and the observed side effects are generally mild with few exceptions.

    It is possible to ingest too much of certain vitamins and minerals (vitamin A, calcium, iron, copper, selenium) which may exacerbate an existing imbalance or lack of another mineral (magnesium, zinc). It is also important to balance intake of fatty acids in the omega-6 and omega-3 series, as most people get too much omega-6 and not enough omega-3.

    Small children can be overdosed with adult doses of for example vitamin A or iron, and pills may be dangerous for babies or young children because they can get stuck in the throat. Therefore, I recommend consulting a doctor or nutritionist educated in orthomolecular medicine. Most people are likely to benefit from taking a broad-spectrum multivitamin/mineral supplement as a basic insurance against deficiencies.

    Compared to pharmaceutical drugs, supplements of most essential nutrients are quite harmless. However, some supplements may have poor quality, or contain toxic metals such as lead or cadmium. Therefore, it is the duty of our authorities to ensure that potentially hazardous products or supplements of poor quality are not sold, and that consumers are offered fair prices in a free market.

    An example where the Norwegian authorities do not follow up such basic duties is that pharmacies demand more than 1,600 Norwegian Kroner (about $190) per kg of vitamin C in powder form, which would cost less than $20 with free competition and no restrictions in permitted doses or outlets.

    Those who want to use natural healing methods, such as the use of food and supplements of essential nutrients to prevent or reverse illness, should consult therapists who are qualified to give advice on how natural therapies can help.

    I recommend that anyone interested in supplements read the references for this article as well as the archives of the Journal of Orthomolecular Medicine http://orthomolecular.org/library/jom/ and the Orthomolecular Medicine News Service http://orthomolecular.org/resources/omns/index.shtml . Both are free access online.

    (Dag Viljen Poleszynski, PhD, is the editor of Helsemagasinet [Health Magazine] https://vof.no/arkiv/ . He has translated and published a large number of OMNS releases in Norwegian.)

     

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    39. Unlu NZ, Bohn T, Clinton SK et al. Carotenoid absorption from salad and salsa by humans is enhanced by the addition of avocado or avocado oil. The Journal of Nutrition 2005; 135: 431-6. https://www.ncbi.nlm.nih.gov/pubmed/15735074

    40. Boback SM, Cox CL, Ott BD et al. Cooking and grinding reduces the cost of meat digestion. Comparative biochemistry and physiology. Part A, molecular & integrative physiology 2007; 148: 651-6. https://www.ncbi.nlm.nih.gov/pubmed/17827047

    41. Carmody RN, Wrangham RW. Cooking and the human commitment to a high-quality diet. Cold Spring Harbor Symposium on Quantitative Biology 2009; 74: 427-34. https://www.ncbi.nlm.nih.gov/pubmed/19843593

    42. Hoffer A, Saul AW. Orthomolecular medicine for everyone. Laguna Beach, CA: Basic Health Publications, Inc., 2008. ISBN-13: 978-1591202264

    43. Hjartåker A, Pedersen JI, Müller H mfl. Grunnleggende ernæringslære. 3. utgave. [Basic nutrition] Oslo: Gyldendal Norsk Forlag AS, 2017.

    44. Levy TE. Vitamin C, infectious diseases, & toxins. Curing the incurable. 3rd Edition. (c)Thomas E. Levy 2011. Medfox Pub. ISBN-13: 978-0977952021

    45. Pauling L. How to live longer and feel better. New York: W. H. Freeman and Company, 1986. ISBN-13: 978-0870710964

    46. Cathcart, RF III. The method of determining proper doses of vitamin C for the treatment of disease by titrating to bowel tolerance. Journal of Orthomolecular Medicine 1981; 10: 125-32. http://orthomolecular.org/library/jom/1981/pdf/1981-v10n02-p125.pdf

    47. Lazarou J, Pomeranz BH, Corey PN. Incidence of adverse drug reactions in hospitalized patients. A meta-analysis of prospective studies. JAMA 1998; 279: 1200-5. https://jamanetwork.com/journals/jama/fullarticle/187436

    48. Moore TJ, Cohen MR, Furberg CD. Serious adverse drug events reported to the Food and Drug Administration, 1998-2005. Archives of Internal Medicine 2007; 167: 1752-9. https://www.ncbi.nlm.nih.gov/pubmed/17846394 .

    49. Hitchen L. Adverse drug reactions result in 250 000 UK admissions a year. BMJ 2006; 332: 1109. https://www.ncbi.nlm.nih.gov/pubmed/16690649 .

    50. Befring AKC. Helse- og omsorgsrett. [Health and Care] Oslo: CappelenDamm AS, 2017.

    Nutritional Medicine is Orthomolecular Medicine

    Orthomolecular medicine uses safe, effective nutritional therapy to fight illness. For more information: http://www.orthomolecular.org

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  • METHYLATION CYCLE, GENETICS, B VITAMINS

    Dr. Hank Liers, PhD geneticsI previously published "Homocysteine Genetics – Coenzyme B Vitamins" in which I considered in-depth how homocysteine (an intermediate chemical in the Methylation Cycle) is formed from methionine, how genetics affects the metabolic pathways, and how B vitamins are used in metabolic pathways. I also wrote "Folate Ingredients – Folinic Acid & 5-MTHF" which discussed how coenzyme folate vitamins are far superior to the synthetic folic acid form. In today's article, I take a broader view of the topic that encompasses the Methylation Cycle, genetics, and B vitamins.

    THE METHYLATION CYCLE

    The Methylation Cycle is considered to be one of the most important metabolic pathways in the human body. Its most important function is to provide methyl groups via SAM (S-adenosyl methionine) to hundreds of different body substrates. Methylation is continually occurring in the body, transforming many millions of molecules throughout the body every second. Molecules receive methyl groups, then separate and recombine continuously, transforming and reforming constantly in the ongoing process of life!

    As a reminder of the pathways involved in the Methylation Cycle, the following figure provides a flow chart showing the details.

    Methylation Cycle

    Figure 1. Metabolic Pathways in Methylation Cycle

    A key purpose of this cycle is to provide methyl groups (CH3) needed by a broad range of of body functions (over 200 different functions). Examples include:

    1. Influences the genetic expression that parents give their children and helps guide the development of the embryo.
    2. Is needed by the nervous system to produce neurotransmitters and maintain the nerves.
    3. Mobilizes fats and cholesterol so they do not accumulate where they are harmful, such as the arteries and liver.
    4. Regulates hormones, including, estrogen, adrenaline, and melatonin.
    5. Detoxifies harmful chemicals and histamine a prime substance involved in inflammation.
    6. Helps repair damaged proteins in the cells so they can function properly.
    7. Protects the DNA in the genome (genetic code) to reduce the chances of mutation.
    8. Creates antioxidants used in the antioxidant defense system.

    DESCRIPTION OF PATHWAYS WITHIN THE METHYLATION CYCLE

    The overall flow of the Methylation Cycle begins with dietary methionine (an essential amino acid) which combines with ATP (adenosine triphosphate - body energy) to form SAM (S-adenosyl methionine) – the common cosubstrate involved in methyl group transfers, transsulfuration, and aminopropylation. When SAM transfers a methyl group to a body chemical the residue from this reaction leads to the production of homocysteine.

    Homocysteine can be converted in the transsulfuration pathway that requires coenzyme vitamin B6 to produce cysteine, glutathione, taurine, and sulfates. These sulfur containing substances provide important antioxidant protection and detoxification functions in the body.

    Homocysteine can be converted back to methionine through the betaine (trimethyl glycine) pathway which requires zinc and magnesium. This pathway also requires dietary betaine or choline which the body can convert into betaine.

    Also, homocysteine can be converted back to methionine via the remethylation pathway which requires 5-MTHF, coenzyme vitamin B2 and methylcobalamin (B12).

    GENETICS

    It is important to understand that each of the pathways described above are able to be executed only in the presence of enzymes (shown in blue boxes in the diagram) created by specific genes in your genetic code. For example, Betaine-Homocysteine S-Methyltransferase (BHMT) is the enzyme required in the betaine pathway, Cystathione Beta Synthase (CBS) is the enzyme required in the transsulfuration pathway, and Methylenetetrahydrofolate Reductase (MTHFR) and Methionine Synthase (MS) are enzymes required in the remethylation pathway.

    Assuming that you have perfect genetics (no mutations, SNPs, free radical damage, insertions/deletions, etc.), the proper functioning of these pathways are still subjected to the fact that the required vitamins and minerals (vitamin B6, vitamin B2, Folate, vitamin B12, zinc, magnesium, and betaine) need to be provided by your diet or from supplements for the body to function correctly.

    In addition, exposure to high levels of toxins from your environment and high levels of stress require that the nutritional needs will be even higher for the pathways to work properly. For example, exposure to high levels of toxins requires that the transsulfuration pathway be more active possibly reducing the amount of available methionine to support necessary methyl transfer reactions.

    For these reasons alone the consensus of knowledgeable practitioners is that you should be eating an organic whole foods diet, taking appropriate nutritional supplements, avoiding and eliminating toxins from food, water, and air (living in a clean environment), and avoiding an unduly stressful life. All of these actions fall into the category of Epigenetics which you generally have control over!! Doing these things alone could significantly balance the functioning of your Methylation Cycle and improve your health.

    Unfortunately, few people have perfect genetics which often causes the various pathways in the Methylation Cycle to become imbalanced and unable to correct the dysregulation imposed upon the body. For example, the enzyme MTHFR can have heterozygous (single chromosome) genetic variations in up to 50% of certain populations and homozygous genetic variations (both chromosomes) in 10% or more of certain populations.

    Some disorders that researchers have associated with MTHFR genetic variations include:

    • Alzheimer’s disease
    • Asthma
    • Atherosclerosis
    • Autism
    • Bipolar disorder
    • Bladder issues
    • Blood clots
    • Breast problems
    • Chemical sensitivity
    • Chronic fatigue syndrome
    • Down syndrome
    • Epilepsy
    • Fibromyalgia
    • Gastric problems
    • Glaucoma
    • Heart murmurs
    • High blood pressure
    • Irritable bowel syndrome
    • Leukemia
    • Male infertility
    • Methotrexate toxicity
    • Migraines with aura
    • Multiple sclerosis
    • Myocardial infarction
    • Nitrous oxide toxicity
    • Parkinson’s disease
    • Pulmonary embolisms
    • Schizophrenia
    • Stroke
    • Thyroid issues
    • Unexplained neurologic disease
    • Vascular dementia

    This extensive list is highly significant and tells us that it is very important to have  genetic testing done for the genes/enzymes in the Methylation Cycle pathway. I prefer the BodySync genetic test which evaluates the key Methylation Cycle genes plus many other important genes in a single test.

    B VITAMINS AND MINERALS

    We are strong believers that everyone should start their nutritional program by eating a balanced, organic, whole foods diet. We have been doing this ourselves for the past 30 years. Unfortunately, only a small percentage of people follow this advice and in most cases this leads to poor nutritional status that does not adequately support the body's needs. This is especially true with respect to obtaining the nutrients needed to support the Methylation Cycle.

    Nine of our family members and associates have taken the BodySync genetic test which evaluates the condition of 45 different enzymes including CBS, MTHFR (2 variations), MTR (related to B12 and 5-MTHF as they relate to methionine synthase - MS), and MTRR (related to maintaining B12 levels needed by the MTR enzyme). In every case the results showed at least 2 and up to 4 enzymes had genetic variations. These results indicate that the nutritional requirements for folate as 5-MTHF, vitamin B12 as methylcobalamin, vitamin B6, vitamin B2, magnesium and zinc will likely be significantly greater than normal.

    Given the above information, it seems essential for good health to take nutritional supplements that provide the important nutrients. Below I will discuss various formulas that I have developed and refined over many years that are useful especially for the Methylation Cycle.

    Please note that Health Products Distributors, Inc.  (HPDI) is the preferred supplier of nutritional supplements by the BodySync genetic testing company.

    MULTIVITAMINS

    When looking at the total needs the body has for nutrients that the body does not produce, including fat soluble vitamins (A, D (some), E, K1 and K2), vitamin C, B vitamins (B1, B2, B3, B5, B6, folate, B12, biotin, choline, and inositol), minerals (Ca, Mg, Zn, Se, Cu, Mn, Cr, Mo, K, boron, and vanadium), and betaine it only seems wise to include as a top priority a Multivitamin that includes all of these in what I term therapeutic amounts (carefully selected after evaluating thousands of research studies carried out over many years.)

    In this context, it is important to recognize that every enzymatic reaction in the body requires mineral cofactors in order to carry out its function. A good multivitamin provides many of these required minerals.

    Additionally, the multivitamin should contain ingredient forms that research has confirmed to be the most absorbable and usable by the body. These include coenzyme B vitamins, Krebs cycle (citrate, alpha-ketoglutarate, succinate, fumarate, & malate) minerals, and amino acid chelates.

    In the context of supporting the Methylation Cycle we are looking for specific forms and amounts of B vitamins that can adequately provide the body's needs. The means that there should be coenzyme folate as 5-MTHF of at least 400 mcg, coenzyme vitamin B-12 as methylcobalamin of at least 200 mcg, Vitamin B6 (including significant amounts of pyridoxal 5' phosphate) of at least 40 mg, and Vitamin B2 (including significant amounts of riboflavin 5' phosphate) of at least 25 mg. In addition, magnesium (100 mg) and zinc (at least 20 mg) should be provided.

    Please note that the body's requirements for magnesium is generally accepted by nutritional experts to be higher than 400 mg daily (and as high as 1,000 mg daily). For this reason we generally recommend that a person take supplemental magnesium (such as HPDI's MYO-MAG) at levels over 400 mg daily.

    The two multivitamin formulas Health Products Distributors provides for adults that meet these requirements (and more) are the Hank & Brian's Mighty Multi-Vite and Multi Two (in both capsule and tablet forms). Click on the bottles below for technical details.

    Hank & Brian's Mighty Multi-Vite multivitamin methylation cycle

    Multi Two Caps or Tablets methylation cycle

    B COMPLEX

    In situations where significant genetic variations are present it may be wise to add a B COMPLEX supplement to the MULTIVITAMIN to provide even larger amounts of the needed B vitamins. HPDI provides a B-Complex-50 product that includes significant amounts of coenzyme forms and contains 50 mg of Vitamin B1, 50 mg of Vitamin B2, 100 mg of Vitamin B3, 50 mg of Vitamin B6, 500 mcg of coenzyme folate (both folinic acid and 5-MTHF), 100 mcg of B12 (both methylcobalamin and hydroxocobalmin), 50 mg of Vitamin B5 (pantothenic acid), 500 mg of Biotin, 50 mg of choline, and 50 mg of inositol. Click on the bottle below for technical details.

    B-Complex-50 full spectrum B vitamins with coenzyme forms methylation cycle

    FOLATE AS 5-MTHF

    In situations where an inadequate diet is present and genetic testing indicates an MTHFR variation (especially a homozygous variation) Health Products Distributors provides a 5-MTHF folate supplement that easily absorbs into the body and can be directly used in combination with Vitamin B12 to convert homocysteine to methionine. Click on the bottle below for technical details.

    5-MTHF 1 mg in veggie cap methylation cycle 5-MTHF 1 mg in veggie cap

    B-12 as METHYLCOBALAMIN

    It is often the case for older patients and vegetarians that Vitamin B12 is deficient. In these cases it is wise to supplement with a significant amount of methylcobalamin to ensure that the Methylation Cycle has sufficient to effectively convert homocysteine into methionine. Health Products Distributors Vitamin B12 contains 5 mg of methylcobalamin in sublingual lozenge form that supports excellent absorption even if swallowed and absorbed by diffusion. Click on the bottle below for technical details.

    Vitamin B-12 5 mg methylcobalamin sublingual lozenge methylation cycle Vitamin B-12 – 5 mg Methylcobalamin sublingual lozenge.

    MINERALS

    Magnesium and zinc are two important minerals used in the betaine pathway of the Methylation Cycle in which homocysteine is converted back to methionine.

    In the body magnesium is involved in more than 400 essential metabolic reactions and is required by the adenosine triphosphate (ATP)-synthesizing protein in mitochondria. ATP, the molecule that provides energy for almost all metabolic processes, exists primarily as a complex with magnesium (MgATP). Therefore, it also is involved in converting methionine to SAM.

    Over 300 different enzymes depend on zinc for their ability to catalyze vital chemical reactions. Zinc-dependent enzymes can be found in all known classes of enzymes.

    Health Products Distributors provides 100 mg magnesium/vcap in its MYO-MAG supplement which is especially important in increasing ATP in the Krebs Cycle. This product also contains vitamin B1, vitamin B2, and vitamin B6 with substantial amounts of coenzyme forms and manganese. Click on the bottle below for technical details.

    MYO-MAG with 100 mg magnesium per serving key B vitamins methylation cycle MYO-MAG with 100 mg magnesium per serving and key B vitamins.

    Health Products Distributors provides 25 mg zinc/serving in its Double Zinc Plus supplement. This formula provides zinc in the picolinate and citrate forms as well as 3 mg of P5P (coenzyme B6). Click on the bottle below for technical details.

    Double Zinc Plus supplement with P5P and 25 mg zinc methylation cycle Double Zinc Plus supplement with P5P and 25 mg zinc

    SUMMARY

    The Methylation Cycle is recognized as one of the most important metabolic pathways in the human body. When not properly supported by key B vitamins and minerals, the Methylation Cycle can become severely imbalanced which can lead to a very wide range of poor health conditions. Furthermore, genetic variations in the genes that produce important enzymes allowing the Methylation Cycle to function correctly lead to even further imbalances and greater possibility for conditions of poor health.

    In this article, I have provided insight into how the Methylation Cycle works and how it can be significantly supported by lifestyle changes regarding diet and environment (Epigenetics) and by specific B vitamins and mineral supplements that I have developed over many years. In addition, we have shown that knowledge gained from genetic testing can further provide a critical understanding of your specific needs so that your health can be optimized.

    RELATED HPDI BLOG ARTICLES

    GENETICS, EPIGENETICS & HUMAN BIOLOGY

    Homocysteine Genetics – Coenzyme B Vitamins

     

  • OMEGA-3 ESSENTIAL FATS REMAIN "ESSENTIAL" – A REBUTTAL FROM OMNS

    Fred Liers PhD omega-3 essential fats plus e EFA formulaOmega-3 essential fatty acids (EFA) are critically important for health. That is the reason we at HPDI include them in our foundational supplements system in the form of our Essential Fats Plus E formula. Essential Fats Plus E provides a balanced ratio of 4:1 omega-3 EPA to omega-6 GLA fatty acids proven to optimally support health.

    As important as Omega-3 fats are in good health, various studies conclude they are of little value. In order to help clarity the fallacies found in such studies, this month we re-print the recent article "Omega 3 Fatty Acids and Cardiovascular Disease" from the Orthomolecular News Service (OMNS).

    BACKGROUND

    Essential fats including Omega-3 and Omega-6 are so important to health that we consider them as foundational or "core" to basic nutrition as multivitamins, antioxidants/vitamin C formulas, and high-RNA superfoods, like Rejuvenate! Plus.

    Many of today's health problems relate to deficiencies in Omega-3 essential fatty acids rather than overabundance of it. It makes sense for everyone to supplement their diets with at least a minimum amount of essential fats. This is addition to consuming foods high in Omega-3 (and Omega-6) essential fats, including leafy greens, nuts, seeds, and seed oils. Also, small amounts of wild-caught fish from clean waters. Preferably these fish would come from low on the food chain, such as sardines, herring, or young mackerel, for example.

    In December 2107, my father Hank Liers, PhD, wrote "The Truth about Essential Fatty Acids." In his article, he delves into detail about why essential fatty acids are critical for health.

    The diagram below from Dr. Hank's article shows in detail the pathways for the production and use of fatty acids in the body. In the figure the metabolic pathways (running left to right) for four fatty acids types are shown (top - Omega-3, second - Omega-6, third - Omega-9, bottom - Omega-7). Notice that only the omega-3 and omega-6 oils are considered to be essential fatty acids because they cannot be made in the body. This means they must come from food.

    omega-3 fats omega-6 fats

    Furthermore, an additional diagram from Dr. Hank's article shown below provides details of the omega-6 and omega-3 pathways. Pathway specifics indicate key eicosanoids (series 1 prostaglandins [anti-inflammatory], series 2 prostaglandins [pro-inflammatory], and series 3 prostaglandins [anti-inflammatory]), oil sources, and important nutrient cofactors that are needed for the reactions to take place.

    omega-3 fats omega-6 fats

    In particular, Dr. Hank discusses how superior benefits to health result from a balanced 4:1 ratio between Omega-3 eicosapentanoic acid (EPA) fatty acids and Omega-6 gamma linoleic acid (GLA).

    Below we list some of the functions and benefits obtained when by diet or supplementation the correct ratios and amounts of essential fatty acids are consumed.

    • Regulate steroid production and hormone synthesis
    • Regulate pressure in the eyes, joints, and blood vessels
    • Regulate response to pain, inflammation, and swelling
    • Mediate Immune Response
    • Regulate bodily secretions and their viscosity
    • Dilate or constrict blood vessels
    • Regulate smooth muscle and autonomic reflexes
    • Are primary constituents of cellular membranes
    • Regulate the rate at which cells divide
    • Necessary for the transport of oxygen from the red blood cells to tissues
    • Necessary for proper kidney function and fluid balance
    • Prevent red blood cells from clumping together
    • Regulate nerve transmission

    Dr. Hank also discusses the fallacy of thinking that supplemental Omega-3 fats alone are sufficient to produce health. That is, despite the relative lack of Omega-3 essential fats and the prevalence of Omega-6 fats in modern diets, it is nevertheless the forms (EPA and GLA)—and the critical 4:1 ratio between them—that makes the difference in how they act synergistically for health. The result of Hank's scientific understanding of essential fatty acids has resulted in his formulation of a balanced EFA product, Essential Fats Plus E.

    Orthomolecular Medicine News Service Article "Omega 3 Fatty Acids and Cardiovascular Disease"

    Regarding the Orthomolecular Medicine News Service article "Omega 3 Fatty Acids and Cardiovascular Disease" (republished below) rebutting the "Cochrane Database of Systematic Reviews" which relies on so-called "Evidence Based Medicine" (EBM) to distort truth on Omega-3 essential fatty acids, the fact that Omega-3 fats are under such false attack represents a huge disservice to the public.

    While essential fatty acids may not generate profits for corporations—and in fact may lead to improved health outcomes that threaten the use of chemicals and drugs—essential fats nevertheless remain foundational for health.

    Above we have shown the important reasons Omega-3 fats and other essential fatty acids are scientifically termed "essential." And why people continue taking essential fats, and giving them to their families and children, for supporting health and well-being. Primary among these reasons is that you cannot be healthy without them. Hence, they are essential. Why believe anyone who says otherwise?

    The bottom line: Omega-3 essential fatty acids are critical for health. Supplementing the diet with them is a good idea for nearly everyone. This is especially true because typical diets are proven to be most deficient in Omega-3 among essential fats.

    Below we re-print in full the recent article "Omega 3 Fatty Acids and Cardiovascular Disease" from the Orthomolecular News Service (OMNS) for the benefit of our HPDI blog readers. ~

    ===

    FOR IMMEDIATE RELEASE
    Orthomolecular Medicine News Service, Aug 6, 2018

    Omega-3 Fatty Acids and Cardiovascular Disease

    Commentary by Damien Downing, MBBS, MSB and Robert G. Smith, PhD

    The Cochrane Database of Systematic Reviews has just updated its own review: Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease [1]. Here's our take on it.

    Michael Pollan, the brilliant food writer, reckoned you could sum up what to do about nutrition and diets in 7 words; "Eat food, not too much, mostly plants." That sums up both what's best for humans and what's best for the planet.

    We reckon you can sum up what's wrong with evidence-based medicine (EBM) in 10 words; "Evidence is a waste of data; systematic reviews are palimpsests." You can use that as a knife to quickly dissect this study.

    There are many things wrong with this review. Somebody's PR department has spun the review's "no clear evidence of benefit" into "evidence of no benefit" - absence of evidence becoming evidence of absence. And clearly the media were entirely happy to take that one and run with it.

    Systematic reviews are palimpsests

    What's a palimpsest? Back when things got written on vellum, an animal skin, not on paper, you didn't throw it away; you recycled it and wrote over the original. It was called a palimpsest.

    A systematic review gives an opportunity to write over the conclusions of a whole list of papers with your new version of the truth. You do that by the way that you select and exclude them.

    For instance there was a meta-analysis (that's a systematic review with more numbers) in 2005 that concluded that vitamin E supplements significantly increased the risk of death [2]. The way they did that was to rule out any study with less than 10 deaths - when fewer deaths was exactly the outcome they were supposed to be looking for.

    The reason they gave for doing that was "because we anticipated that many small trials did not collect mortality data." We're not buying it; they used it as a trick to enable them to get the negative result they wanted - to over-write the findings of a long list of original studies.

    And here we have authors doing the very same thing in this omega-3 study - and upping the ante slightly. Now the threshold is 50 deaths. Fewer than that and your study is ruled out of the final, supposedly least biased, analysis . . on the grounds that it's more biased.

    We don't know how they could keep a straight face while saying (our interpretation); "The studies with fewer deaths showed more benefit from omega-3s, so we excluded them." At least that's what happened back in 2004 when the first version of this came out.[3]

    But this is the 8th update (we think) and they no longer bother to tell you about what they included or excluded in detail, so we can only assume that if they had changed that exclusion they would have told us.

    The weird thing is that they are allowed to do it. Nutrition researcher Dr. Steve Hickey has shown that in systematic reviews there is generally control for bias in the included studies, but none for bias in the actual review and its authors.[4,5]

    They found not one example of adequate blinding among 100 Cochrane reviews (like this one); they could all be palimpsests. Do we know that they are fake? No, but it doesn't matter: what we do know is that we can't trust them. Nor can we trust this Cochrane review. Things haven't changed since 2004.

    Evidence is a waste of data

    Evidence is what lawyers and courts use to find someone Guilty or Not Guilty, and we all know how that can go wrong. It's a binary system: you're either one or the other. But at least if you're on trial all the evidence should be about you and whether you did the crime.

    In EBM the evidence is all about populations, not about individuals. When a doctor tells you "There's a 1 in 3 chance this treatment will work" he is required to base that on big studies, or even systematic reviews. You don't, and you can't, know what that means for you because very likely you don't fit the population profile.

    As Steve Hickey (again) said, the statistical fallacy underlying all this states that you have one testicle and one ovary - because that's the population average! The authors of this study update started off with about 2100 papers that looked relevant. They then excluded 90 per cent of them for various reasons - some of them good reasons, some not.

    A smarter way to work would be to data-mine them and look for useful information about sub-groups and sub-effects in all the papers. Is there a particular reason omega-3s might work for you and not for others? Perhaps you can't stand fish, or are allergic to them, and so are deficient in omega-3s.

    But the review system doesn't allow it, it insists on overall conclusions (about populations), and that's a colossal waste of data. It also confounds the overall finding of the review - it biases it in fact.

    Here's an example: while most subgroups that made it to the final analysis showed a small reduction in risk from taking omega-3s in one form or another (pills, food, whatever), those who got it from supplemented foods, which we understand means stuff like margarine with added omega-3, showed a 4.3-fold death risk increase!

    The problem here is that the effects of omega-3 fatty acids cannot be studied alone as if they were a drug. What counts are all the other components of the diet that affect a person's health.

    Processed foods and drinks that contain many unhealthy ingredients can't be made healthy by adding small doses of vitamins, minerals, and omega-3 fatty acids. In fact, many processed foods that contain small doses of vitamins and other essential nutrients are unhealthy because they contain large doses of sugar, salt, and harmful ingredients such as preservatives, dyes, and other non-food items.

    Why lipids are so important

    Part of the problem is that lipids are truly complicated, and not many people, patients, doctors or even scientists, understand them well. You need a good understanding of lipid metabolism to appreciate the difference in metabolism and impact between alpha-linolenic acid (ALA, in food such as oily fish) and extracted oils such as EPA and DHA that are only found at high levels in omega-3 supplements.

    At these levels they are effectively new to nature; nobody, indeed no mammal, was exposed to really high doses of DHA until we invented fish oil supplements [6]. Miss that fact and you miss the difference between having people eat fresh oily fish or just using omega-3 margarine!

    We know from a variety of studies that a diet containing generous portions of green leafy and colorful vegetables and fruits, moderate portions of eggs, fish, and meat, and supplements of adequate doses of essential nutrients (vitamins and minerals) is effective at lowering the risk for cardiovascular disease.

    Adequate doses of both omega-3 (in flax oil, walnuts, fish) and omega-6 (in seed oils such as canola, soybean, peanut) fatty acids are essential for health. Although essential, omega-6 fatty acids are thought to contribute to inflammation throughout the body whereas omega-3 fatty acids are anti-inflammatory.

    Omega-3 fatty acids are essential for most body organs including the brain but are found in lower levels than omega-6 fatty acids in most vegetables. Risk for cardiovascular disease can be lowered by adequate doses of vitamins C (3,000-10,000mg/d), D (2,000-10,000 IU/d), E (400-1,200 IU/d), and magnesium (300-600 mg/d) in addition to an excellent diet that includes an adequate dose of omega-3 fatty acids.[7]

    (Dr. Damien Downing is a specialist physician practicing in London, and President of the British Society for Ecological Medicine. Robert G. Smith is a physiologist and Research Associate Professor at the University of Pennsylvania Perelman School Of Medicine.)

     

    References:

    1. Abdelhamid, A, Brown TJ, Brainard JS, et al., (2018) Omega 3 fatty acids for the primary and secondary prevention of cardiovascular disease. Cochrane Database of Syst Rev. 7:CD003177. https://www.ncbi.nlm.nih.gov/pubmed/30019766
    http://cochranelibrary-wiley.com/doi/10.1002/14651858.CD003177.pub3/abstract

    2. Miller ER, Pastor-Barriuso R, Dalal D, et al., (2005) Review Meta-Analysis?: High-Dosage Vitamin E Supplementation May Increase. Annals of Internal Medicine, 142(1), pp.37-46. Available at: http://annals.org/article.aspx?articleid=718049.

    3. Hooper L, Thompson RL, Harrison RA, et al.. (2004) Omega 3 fatty acids for prevention and treatment of cardiovascular disease. Cochrane Database Syst Rev. (4):CD003177. http://cochranelibrary-wiley.com/doi/10.1002/14651858.CD003177.pub2/abstract

    4. Hickey S, Noriega LA. Implications and insights for human adaptive mechatronics from developments in algebraic probability theory, IEEE, UK Workshop on Human Adaptive Mechatronics (HAM), Staffs, 15-16 Jan 2009.

    5. Hickey S, Hickey A, Noriega LA, (2013) The failure of evidence-based medicine? Eur J Pers Centered Healthcare 1: 69-79. http://ubplj.org/index.php/ejpch/article/view/636

    6. Cortie CH, Else, PL, (2012) Dietary docosahexaenoic acid (22:6) incorporates into cardiolipin at the expense of linoleic acid (18:2): Analysis and potential implications. International Journal of Molecular Sciences, 13(11): 15447-15463. http://www.mdpi.com/1422-0067/13/11/15447

    7. Case HS (2017) Orthomolecular Nutrition for Everyone. Turner Publication Co., Nashville, TN. ISBN-13: 978-1681626574

    Nutritional Medicine is Orthomolecular Medicine

    Orthomolecular medicine uses safe, effective nutritional therapy to fight illness. For more information: http://www.orthomolecular.org

    Find a Doctor

    To locate an orthomolecular physician near you: http://orthomolecular.org/resources/omns/v06n09.shtml

    The peer-reviewed Orthomolecular Medicine News Service is a non-profit and non-commercial informational resource.

    Editorial Review Board:

    Ilyès Baghli, M.D. (Algeria)
    Ian Brighthope, M.D. (Australia)
    Prof. Gilbert Henri Crussol (Spain)
    Carolyn Dean, M.D., N.D. (USA)
    Damien Downing, M.D. (United Kingdom)
    Michael Ellis, M.D. (Australia)
    Martin P. Gallagher, M.D., D.C. (USA)
    Michael J. Gonzalez, N.M.D., D.Sc., Ph.D. (Puerto Rico)
    William B. Grant, Ph.D. (USA)
    Tonya S. Heyman, M.D. (USA)
    Suzanne Humphries, M.D. (USA)
    Ron Hunninghake, M.D. (USA)
    Michael Janson, M.D. (USA)
    Robert E. Jenkins, D.C. (USA)
    Bo H. Jonsson, M.D., Ph.D. (Sweden)
    Jeffrey J. Kotulski, D.O. (USA)
    Peter H. Lauda, M.D. (Austria)
    Thomas Levy, M.D., J.D. (USA)
    Homer Lim, M.D. (Philippines)
    Stuart Lindsey, Pharm.D. (USA)
    Victor A. Marcial-Vega, M.D. (Puerto Rico)
    Charles C. Mary, Jr., M.D. (USA)
    Mignonne Mary, M.D. (USA)
    Jun Matsuyama, M.D., Ph.D. (Japan)
    Dave McCarthy, M.D. (USA)
    Joseph Mercola, D.O. (USA)
    Jorge R. Miranda-Massari, Pharm.D. (Puerto Rico)
    Karin Munsterhjelm-Ahumada, M.D. (Finland)
    Tahar Naili, M.D. (Algeria)
    W. Todd Penberthy, Ph.D. (USA)
    Dag Viljen Poleszynski, Ph.D. (Norway)
    Jeffrey A. Ruterbusch, D.O. (USA)
    Gert E. Schuitemaker, Ph.D. (Netherlands)
    Thomas L. Taxman, M.D. (USA)
    Jagan Nathan Vamanan, M.D. (India)
    Garry Vickar, MD (USA)
    Ken Walker, M.D. (Canada)
    Anne Zauderer, D.C. (USA)

    Andrew W. Saul, Ph.D. (USA), Editor-In-Chief
    Editor, Japanese Edition: Atsuo Yanagisawa, M.D., Ph.D. (Japan)
    Robert G. Smith, Ph.D. (USA), Associate Editor
    Helen Saul Case, M.S. (USA), Assistant Editor
    Ralph K. Campbell, M.D. (USA), Contributing Editor
    Michael S. Stewart, B.Sc.C.S. (USA), Technology Editor
    Jason M. Saul, JD (USA), Legal Consultant

    Comments and media contact: drsaul@doctoryourself.com OMNS welcomes but is unable to respond to individual reader emails. Reader comments become the property of OMNS and may or may not be used for publication.

    To subscribe to the Orthomolecular Medicine News Service (free): http://www.orthomolecular.org/subscribe.html

    OMNS Archive: http://orthomolecular.org/resources/omns/index.shtml

    To view this article on the OMNS website: http://www.orthomolecular.org/resources/omns/v14n17.shtml

  • BASHING VITAMINS BY META-ANALYSIS – SATIRICAL COMMENTARY BY ORTHOMOLECULAR NEWS

    Fred Liers PhD vitamins meta analysis orthomolecular news serviceDr. Andrew Saul, editor of the Orthomolecular News Service (OMNS), recently wrote a satirical commentary "How to Bash Vitamins with a Meta-Analysis." This satire takes the form of a memorandum from the world headquarters of pharmaceutical politicians, educators, and reporters (WHOPPER).

    The specific vitamin-bashing meta-analysis which prompted Dr. Saul's satire is titled  "Supplemental Vitamins and Minerals for CVD Prevention and Treatment" and published in Journal of the American College of Cardiology. The meta-analysis finds nutritional supplements useless, or with negligible benefit, and even dangerous. These conclusions would be laughable except that it is presented to the public as based on sound science. It is not.

    Of note is the fact that the meta-analysis relies on studies using low-dose supplementation, as well as studies using synthetic forms of vitamins and not natural coenzyme forms. For example, folic acid instead of natural folates.

    Meta-analyses such as this one are tired, trite, and re-cycled every few years, as if somehow they are "news." Moreover, the meta-analysis discloses significant conflicts of interest, which not only is disturbing, but also indicates a bias against supplements that makes its false conclusions even less trustworthy.

    We re-publish Dr. Saul's satirical commentary in full below. It is important to put truth distorting meta-analyses like this one in their place on the spectrum of truth. In the case of this meta-analysis, it is literally off the chart. (Pun intended.) ~

    FOR IMMEDIATE RELEASE
    Orthomolecular Medicine News Service, May 29, 2018

    How to Bash Vitamins with a Meta-Analysis

    A Confidential Memorandum from the World Headquarters of Pharmaceutical Politicians, Educators and Reporters (WHOPPER)

    Satire by Andrew W. Saul, Editor

    TOP SECRET: Do Not Let This Get on the Internet! No Leaks!

    Distinguished members, our decades of disparaging nutritional therapy have paid off at last. The public, and their healthcare providers, are completely hoodwinked. By pushing "evidence based medicine" on the medical professions, we have elegantly slipped in our choice of evidence to base medicine on. And this is no mere journeyman accomplishment: this is high art. Mr. Machiavelli would be pleased. Certainly the pharmaceutical cartel is. We are well on our way to eliminating the competition, namely that increasingly irritating "orthomolecular medicine" faction.

    Here's how we are winning the Vitamin War: It is entirely too obvious, from our reading the nutritional literature, that vitamins and minerals are a well-proven, safe and effective therapy. Of course, anyone knows that to work they must be employed in appropriate doses, just as any drug must be given in an appropriate dose. That is the problem, but it is also our opportunity. Since high nutrient doses work all too well, we eliminate all those embarrassing positive high-dose studies simply by ignoring them. By selecting, pooling and analyzing only unsuccessful low dose studies, our conclusions exactly fit what we want the public to believe.

    We have established that research data can easily be cherry-picked and meta-analyzed to further our agenda. And, of course, the huge amount of cash we spend on advertising assures that both the medical journals and the mass media will limit discussion to what we approve of. It is now a mere step to do the same in other disciplines, including education, politics, and the social sciences. For example:

    • Using data only from poorly funded urban schools, we can prove mathematically, by statistical analysis of grade-point-averages, that inner-city kids have no academic future.
    • By collecting data as to how many 19th century women graduated from college, we can show that women then were not as qualified to vote as men are today, and overturn the 19th amendment.
    • If we assemble data on screen time and analyze actors' roles from Hollywood movies made in the 1920s and 1930s, we can demonstrate that some races are best qualified to be domestic workers, tap dancers or to operate laundries.
    • By giving a large sample of the homeless 25 cents each, we can show that higher personal income is ineffective against poverty.
    • If we tabulate inventory at Ferrari dealerships exclusively, we can prove Hondas are scarce.
    • Repeatedly taking the temperature of thousands of cadavers is justification that funeral homes do not need central heating, at least not at night.

    Here is unlimited opportunity for social engineering. It logically proceeds from our widely publicized analyses of vitamin supplementation, analyses that were (of course!) limited to studies that used low doses. Political mathematics is a wonderful thing: select your data and meta-analyze it into truth.

    Don't worry: the public will accept it. After all, we just did a meta-analysis of the words of Abraham Lincoln. What he REALLY meant to say is that you can fool all of the people all of the time.

    We shall continue to act accordingly.

    (End of memo)

    The above satirical commentary is in reply to yet another vitamin-bashing report. This particular one is Supplemental vitamins and minerals for CVD prevention and treatment. J Amer Col Cardiology 2018, 71:22.

    The Orthomolecular Medicine News Service strongly disagrees with allegations that supplements are basically useless or even harmful.

    Dr. Michael Ellis (Australia) says:

    "There are hundreds of papers in the New England Journal of Medicine, JAMA, and other journals which support the use of orthomolecular medicine to prevent and cure chronic disease. The paper discussed here does not take into account dosages of vitamins and bioavailability. The meta analyses are therefore biased and not accurate."

    Dr. Damien Downing (United Kingdom) says:

    "This should be a rule: never trust a study with more metadata than data. This study is a review of reviews - a meta-meta-analysis. Selecting multiple studies introduces another level of judgment, with new potential for bias. Just as peer reviewers can introduce their own bias, so can review authors; some evidence indicates that reviewers bias selection significantly in favor of their own final conclusions."

    The financial interests of the study's authors makes VERY interesting reading. To see this truly enormous list, you have to scroll way, way down at https://www.sciencedirect.com/science/article/pii/S0735109718345601 Interestingly, if you download the paper, you do not get the conflict of interest section with it. You have to see it online to get the whole story. How about that.

    (Andrew W. Saul has been Editor-in-Chief of the Orthomolecular Medicine News Service for 14 years. You can watch videos where he rebuts other attacks against vitamin and mineral supplements at https://www.youtube.com/watch?v=88aUHMP3eN8&index=2&list=PL7YKya_R1ROuUyBFbKLeAp8iIITihxB-g and also at https://www.facebook.com/themegavitaminman/videos/265980030275194/ )

    Nutritional Medicine is Orthomolecular Medicine

    Orthomolecular medicine uses safe, effective nutritional therapy to fight illness. For more information: http://www.orthomolecular.org

    Find a Doctor

    To locate an orthomolecular physician near you: http://orthomolecular.org/resources/omns/v06n09.shtml

    The peer-reviewed Orthomolecular Medicine News Service is a non-profit and non-commercial informational resource.

    Editorial Review Board:

    Ilyès Baghli, M.D. (Algeria)
    Ian Brighthope, M.D. (Australia)
    Prof. Gilbert Henri Crussol (Spain)
    Carolyn Dean, M.D., N.D. (USA)
    Damien Downing, M.D. (United Kingdom)
    Michael Ellis, M.D. (Australia)
    Martin P. Gallagher, M.D., D.C. (USA)
    Michael J. Gonzalez, N.M.D., D.Sc., Ph.D. (Puerto Rico)
    William B. Grant, Ph.D. (USA)
    Tonya S. Heyman, M.D. (USA)
    Suzanne Humphries, M.D. (USA)
    Ron Hunninghake, M.D. (USA)
    Michael Janson, M.D. (USA)
    Robert E. Jenkins, D.C. (USA)
    Bo H. Jonsson, M.D., Ph.D. (Sweden)
    Jeffrey J. Kotulski, D.O. (USA)
    Peter H. Lauda, M.D. (Austria)
    Thomas Levy, M.D., J.D. (USA)
    Homer Lim, M.D. (Philippines)
    Stuart Lindsey, Pharm.D. (USA)
    Victor A. Marcial-Vega, M.D. (Puerto Rico)
    Charles C. Mary, Jr., M.D. (USA)
    Mignonne Mary, M.D. (USA)
    Jun Matsuyama, M.D., Ph.D. (Japan)
    Dave McCarthy, M.D. (USA)
    Joseph Mercola, D.O. (USA)
    Jorge R. Miranda-Massari, Pharm.D. (Puerto Rico)
    Karin Munsterhjelm-Ahumada, M.D. (Finland)
    Tahar Naili, M.D. (Algeria)
    W. Todd Penberthy, Ph.D. (USA)
    Dag Viljen Poleszynski, Ph.D. (Norway)
    Jeffrey A. Ruterbusch, D.O. (USA)
    Gert E. Schuitemaker, Ph.D. (Netherlands)
    Thomas L. Taxman, M.D. (USA)
    Jagan Nathan Vamanan, M.D. (India)
    Garry Vickar, MD (USA)
    Ken Walker, M.D. (Canada)
    Anne Zauderer, D.C. (USA)

    Andrew W. Saul, Ph.D. (USA), Editor-In-Chief
    Editor, Japanese Edition: Atsuo Yanagisawa, M.D., Ph.D. (Japan)
    Robert G. Smith, Ph.D. (USA), Associate Editor
    Helen Saul Case, M.S. (USA), Assistant Editor
    Ralph K. Campbell, M.D. (USA), Contributing Editor
    Michael S. Stewart, B.Sc.C.S. (USA), Technology Editor
    Jason M. Saul, JD (USA), Legal Consultant

    Comments and media contact: drsaul@doctoryourself.com OMNS welcomes but is unable to respond to individual reader emails. Reader comments become the property of OMNS and may or may not be used for publication.

    To subscribe to the Orthomolecular Medicine News Service (free): http://www.orthomolecular.org/subscribe.html

    OMNS Archive: http://orthomolecular.org/resources/omns/index.shtml

    To view this article on the OMNS website: http://www.orthomolecular.org/resources/omns/v14n16.shtml

    Read abstract of the meta-analysis: "Supplemental Vitamins and Minerals for CVD Prevention and Treatment." J Am Coll Cardiol. 2018 Jun 5;71(22):2570-2584. doi: 10.1016/j.jacc.2018.04.020.

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