Health Products Distributors

Nutrisync

  • GENETICS, EPIGENETICS & HUMAN BIOLOGY

    Genetics, Epigenetics, and Human Biology

    Dr. Hank Liers, PhD geneticsWe are entering a time in which new scientific tools are available that provide clear insights regarding the causes of poor health, as well as therapies that can be used to overcome health issues. Specifically, these tools include 1) our understanding and ability to characterize the human genome, and 2) advances in the science of epigenetics showing how environmental factors significantly influence the expression of genetics and human biology.

    For many years, my company (Health Products Distributors, Inc. – "HPDI") has been involved in Rejuvenation/Healing Programs which take multiple health modalities into consideration (for information on HPDI's Rejuvenation/Healing Programs, see Additional Resources below). Our programs have generally involved the following elements:

    1. Health-Building Nutrition
      Rejuvenation begins with nutrition in the broadest sense. That is, nutrition derived from healthy foods, superfoods, supplements, dietary nucleic acids, water and fluids, as well as via the skin. Establishing health-building nutrition is foundational to rejuvenating the body, mind, and spirit.
    2. Detoxification & Preventing Toxicity
      Individuals cannot fully experience rejuvenation without having effective means for removing existing toxins form the body, or for stopping further accumulation of toxins absorbed from foods, air, water, and skin. Such toxins include everything from chemicals in foods and water to the many toxins found in homes, workplaces, personal products, and just about everywhere.
    3. Building Powerful Immunity
      Building immunity is important for health because the immune system is the means by which the body defends itself. Yet, if the best defense is a strong offense, then having a strong immunity protects us in ways beyond just defense. Building immunity is accomplished not only by nutrition, but also by utilizing herbs, immune boosting supplements, and immune-enhancing protocols.
    4. Supporting Protocols
      Certain practices and protocols powerfully support rejuvenation. These protocols include exercise, massage, saunas/hydrotherapy,  yoga, acupuncture, meditation, and others.
    5. Attitude and Commitment to Becoming Healthy
      Attitude and Commitment are foundational to your rejuvenation/healing program because having total focused intention regarding your health is essential for success. If a journey of a thousand miles begins with a single step, establishing that intention perspective is a great place to start.

    ADDING GENETICS TEST TO HPDI REJUVENATION PROGRAM

    In the last few years, we have seen how healing and wellness programs can be significantly enhanced by adding genetics testing into the mix. In fact, we have joined forces with BodySync, a company with the most advanced single genetics test available. This test characterizes 45 different genes and gene variations. The Bodysync genetics test results are combined with basic lifestyle information provided by the patient to create a complete program customized for dealing with gene variations having either harmful or helpful effects.

    The insights gleaned by taking the BodySync genetics test provides new insights into reasons a person may experience health challenges that no other method can provide. The test results and action plan also provide information regarding genetic strengths, especially related to athletic performance and weight management.

    The NutriSync test from BodySync genetics

    HPDI now adds the BodySync genetics test to the list of key elements in our rejuvenation/healing programs. In fact, we are now introducing the BodySync genetic test along with consultations to our HPDI Reseller Associates—so that health practitioners (HPs) can experience the benefits of the test for themselves— and see how genetics consulting can be added to their practice. In addition, BodySync has selected HPDI as their preferred supplier of nutritional supplements supporting the recommendations provided in their Action Plans for individuals taking the test. It is exciting to be part of this breakthrough in the practice of genetic science.

    BROAD OVERVIEW OF GENETICS, EPIGENETICS, AND HUMAN BIOLOGY

    In order to give a more complete understanding of our program for attaining excellent health, we have developed a broad scientific overview of how all the key elements are related and eventually expressed as YOU.

    The diagram below provides a broad overview of genetics, epigenetics, and human biology with the goal of showing how the elements are interrelated. More discussion on the key elements is provided below the diagram.

    Genetics, Epigenetics, and Human Biology genetics

     

    GENOME

    The human genome is the sum of the body's DNA and is considered to be static for each individual—remaining the same over a lifetime. The human genome contains all the instructions needed to make the full range of human cell types including muscle cells and neurons. This includes all of the body's DNA, both the genes (the coding regions) and the noncoding DNA, as well as the genetic material of the mitochondria and chloroplasts.

    With the breakthrough in gene testing now available, it is possible to isolate relevant genes from a field of  approximately 20,000 different genes. These 20,000 different genes make up less than 2% of the total amount of DNA.

    It has been found that the underlying gene patterns can exhibit "genetic variations". Ultimately, genetic variations are caused by variations in the order of bases in the nucleotides in genes. New technology, such as that used in the BodySync genetics test, allows scientists to directly sequence DNA which has identified even more genetic variation than was previously detected by previous methods such as protein electrophoresis.

    Examination of DNA has shown genetic variation in both coding regions and in the non-coding intron (nonprotein-coding sections) region of genes. Mutation is the ultimate source of genetic variation, but mechanisms such as sexual reproduction and genetic drift contribute to it as well.

    Genetic variation will result in phenotypic variation if variation in the order of nucleotides in the DNA sequence results in a difference in the order of amino acids in proteins coded by that DNA sequence, and if the resultant differences in amino acid sequence influence the shape, and thus the function of the enzyme.

    Genetic variations/base substitutions can change a codon to one that encodes a different amino acid and cause a small change in the protein produced. For example, sickle cell anemia is caused by a substitution in the beta-hemoglobin gene, which alters a single amino acid in the protein produced.

    Genetic variations can change a codon to one that encodes the same amino acid and causes no change in the protein produced. These are called silent mutations.

    Also, base substitutions can change an amino-acid-coding codon to a single "stop" codon and cause an incomplete protein. This can have serious effects since the incomplete protein probably won't function.

    In some genetic variations there may be a piece of the DNA deleted or inserted in a gene that may also lead to Present/Insertion or Deletion variation (INDEL). Since protein-coding DNA is divided into codons three bases long, insertions and deletions can alter a gene so that its message is no longer correctly parsed.

    When it comes to genetic traits, scientists look at genes and the locus where that gene or trait encodes on the chromosome. Since humans possess two copies of each chromosome, they also have two copies of each gene and locus on those chromosomes. Each of these trait-encoding genes (or loci) is called an allele. If the alleles match, the person is homozygous for that trait. If the alleles are different, the person is heterozygous for that trait.

    If a mutation occurs in just one copy of the gene then that individual is considered heterozygous. On the other hand if both copies of a gene are mutated then that individual is homozygous genotype. Many of these mutations can have undesirable health affects for an individual.

    BodySync's technology has helped to usher in the age of personalized nutrigenomics. The company has built its intellectual property and technology to support its vision of providing services in partnership with health care professionals (HP). BodySync's NutriSync (NS) genetics test consists of only the most well-researched genetic variations with direct applicability to actionable personalized health and wellness recommendations (most of which fall into the epigenetic category).

    The NutriSync genetics test has been based on evaluations of thousands of peer reviewed articles, published research papers, and human intervention studies, as well as extracting data of tens of thousands of DNA and self-reported lifestyle samples in its database.

    EPIGENOME

    The human epigenome serves as a bio-record of chemical changes that have occurred in a person's DNA and their histone proteins. Unlike the underlying genome which is largely static within an individual, the epigenome can be dynamically altered by environmental conditions. For example methyl groups from the diet can tag DNA and activate or repress certain genes as shown in the diagram below.

    The epigenome is involved in regulating gene expression, development, tissue differentiation, and suppression of transposable elements. These changes in underlying DNA and histone proteins can be passed down to an organism's offspring via transgenerational epigenetic inheritance. Changes to the epigenome can result in changes to the structure of chromatin and changes to the function of the genome.

    EPIGENETICS

    Epigenetics, on the other hand, is the study of changes in gene expression (active versus inactive genes) that do not involve changes to the underlying DNA sequence — a change in phenotype (the manifestation that is YOU) without a change in genotype — which in turn affects how cells read the genes. To be sure, epigenetic change is a regular and natural occurrence in our bodies, but can also be influenced by several factors including age, the environment/lifestyle, drug usage, and disease state.

    Epigenetic modifications can manifest as commonly as the manner in which cells terminally differentiate to end up as skin cells, liver cells, brain cells, etc. Also, epigenetic change can have more damaging effects that can result in diseases like cancer. At least three epigenetic mechanisms (two of which are shown in the diagram below) including DNA methylation, histone modification, and non-coding RNA (ncRNA)-associated gene silencing are currently considered to initiate and sustain epigenetic change.

    genetics epigenetics mechanisms

    ENVIRONMENT

    In this context the term "ENVIRONMENT" refers to all of the "external" influences we experience. In the diagram we list what are generally considered to be positive and negative factors contributing to our overall health.

    Some of these factors such as free-radicals and drug use affect our genome directly. Environmental agents such as UV light, ionizing radiation, and genotoxic chemicals (e.g. the drug thalidomide) can cause DNA damage. DNA damage is very frequent, occurring on average about 10,000 times a day per cell of the human body.

    These damages are largely repaired, but at the site of a DNA repair, epigenetic changes can remain. In particular, a double strand break in DNA can initiate unprogrammed epigenetic gene silencing both by causing DNA methylation, as well as by promoting silencing types of histone modification.

    The field of epigenetics is rapidly growing and with it the understanding that both the environment and individual lifestyle directly interact with the genome to influence changes in the way various genes are expressed. These changes may be reflected at various stages throughout a person’s life and even in later generations. For example, human epidemiological studies have provided evidence that prenatal and early postnatal environmental factors influence the adult risk of developing various chronic diseases and behavioral disorders.

    Also, research has also shown that a mother’s exposure to pollution could impact her child's asthma susceptibility and her intake of Vitamin D could change DNA methylation that influences placenta functioning. It doesn’t stop at the mother, however, as further studies support that the father has a hand in his child’s health and epigenetic marks, as well.

    Although our epigenetic marks are more stable during adulthood, they are still thought to be dynamic and modifiable by lifestyle choices and environmental influence. It is becoming more apparent that epigenetic effects occur not just in the womb, but over the full course of a human life span, and that epigenetic changes could be reversed. There are numerous examples of epigenetics that show how different lifestyle choices and environmental exposures can alter marks on top of DNA and play a role in determining health outcomes.

    The environment is being investigated as a powerful influence on epigenetic tags and disease susceptibility. Pollution has become a significant focus in this research area as scientists are finding that air pollution could alter methyl tags on DNA and increase one’s risk for neurodegenerative disease. Also, adequate amounts of B vitamins may protect against harmful epigenetic effects of pollution and may be able to combat the harmful effects that particulates have on the body.

    Diet has also been shown to modify epigenetic tags in significant ways. The field of nutriepigenomics explores how food and nutritional supplements and epigenetics work together to influence health and well being. For example, a study found that a high fat, low carbohydrate diet could open up chromatin and improve mental ability via HDAC (histone deacetylase) inhibitors.

    Other studies have found that certain compounds within the foods we consume could protect again cancer by adjusting methyl marks on oncogenes or tumor suppressor genes. Ultimately, an epigenetic diet may guide people toward the optimal food regimen as scientific studies reveal the underlying mechanisms and impact that different foods have on the epigenome and health.

    RNA/PROTEIN

    Ribonucleic acid (RNA) is a polymeric molecule essential in various biological roles in coding, decoding, regulation, and expression of genes. RNA and DNA are nucleic acids, and, along with lipids, proteins and carbohydrates, constitute the four major macromolecules essential for all known forms of life.

    Like DNA, RNA is assembled as a chain of nucleotides, but unlike DNA it is more often found in nature as a single-strand folded onto itself, rather than a paired double-strand. Cellular organisms use messenger RNA (mRNA) to convey genetic information that directs synthesis of specific proteins.

    These protein molecules are the "workhorses" of the cell carrying out all the functions necessary for life. For example, enzymes, including those that metabolize nutrients and synthesize new cellular constituents, as well as DNA polymerases and other enzymes that make copies of DNA during cell division, are all proteins.

    PHENOTYPE

    Your phenotype is a description of your actual physical characteristics. This includes straightforward visible characteristics like your height and eye color, but also your overall health, your disease history, and even your behavior and general disposition. Do you gain weight easily? Are you anxious or calm? Do you like cats? These are all ways in which you present yourself to the world, and as such are considered phenotypes.

    However, not all phenotypes are a direct result of your genotype; chances are that your personal disposition to cats is the result of your life’s experience with pets (epigenetic) rather than a mutation in a hypothetical cat fancier gene.

    Most phenotypes are influenced by both your genotype and by the unique circumstances in which you have lived your life, including everything that has ever happened to you (epigenetic). We often refer to these two inputs as “nature,” the unique genome you carry, and “nurture,” the environment in which you have lived your life.

    HEALTH AND DISEASE

    Your phenotype expresses who YOU are in a multitude of ways and in particular shows your strengths and weaknesses regarding health, mental abilities, and athletic performance to name a few. By incorporating genetics and epigenetic tests and controlling your environment in positive ways your strengths can be expressed more easily and your weaknesses minimized!!

    CONCLUSION

    I have provided an overview of how genetics testing provides new scientific insights into many health issues that have previously not been well understood. An overview of genetics, epigenetic, and human biology has been provided that shows the overall relationships of these topics. Hopefully, the rationale is clear for adding genetic testing into programs that provide protocols for more successful healing regimens.

     

    ADDITIONAL RESOURCES

    HOMOCYSTEINE GENETICS – COENZYME B VITAMINS

    REJUVENATION PROGRAM SERIES

    Rejuvenation Program Part Ten: The Yoga Program

    Rejuvenation Program Part Nine: Acupuncture. Supporting Protocols Part Four – Acupuncture and Traditional Chinese Medicine (TCM).

    Rejuvenation Program Part Eight: Massage. Supporting Protocols Part Three – The Massage Program.

    Rejuvenation Program Part Seven. Supporting Protocols Part Two – The Magnesium Chloride Program

    Rejuvenation Program Part Six. Supporting Protocols Part One (garlic, hydrotherapy, and sauna therapy programs).

    Rejuvenation Program Part Five. Beyond foundational supplements. Seven enhancement supplements that supercharge your health. CoenzymeQ10 and/or Ubiquinol, Myo-Mag, Hepa Plus, Nascent Iodine, Echinacea, Immune-Assist™.

    Rejuvenation Program Part Four. The role of foundational supplements (multivitamin, Vitamin C / antioxidant formula, Rejuvenate!™ superfoods) for health.

    Rejuvenation Program Part Three. Health building nutrition and the role of dietary nucleic acids (RNA, DNA, nucleosides, and nucleotides).

    Rejuvenation Program Part Two. Foundational elements in the HPDI Rejuvenation Program: 1) Attitude/Commitment, 2) Detoxification, 3) Preventing Toxicity, 4) Health Building Nutrition, 5) Building Powerful Immunity, and 6) Supporting Protocols.

    Rejuvenation Program Part One. Introducing the HPDI Master Rejuvenation Program and its foundational elements. The importance of Attitude/Commitment.

     

  • MULTIVITAMINS – WHY YOU NEED THEM

    Fred Liers PhD multivitaminsMultivitamins are the most important of the basic or foundational supplements providing nutrients essential for health and wellness. Because if there is a single nutritional supplement everyone should take, a multivitamin is it.

    But it can't be just any multivitamin. The best multivitamins are complete, high-potency, high-quality, high-purity, provide a complete range of essential vitamins and minerals, and contain advanced forms—more about advanced forms later.

    The purpose of taking a high-potency multivitamin not only is to provide the body with amounts and forms of nutrients meeting minimum requirements for avoiding deficiency conditions, but also sufficient levels of nutrients that can support optimal health. Because vitamins levels for optimal health are NOT the same as levels required to avoid deficiency conditions.

    MORE THAN DAILY ALLOWANCES

    While 40% of Americans say they take a multivitamin daily, how many actually obtain all the nutrients they need for optimal health from taking it? Practically no one. Why?

    Because basic "recommended daily amounts" (100% of daily allowance) typically found in multivitamins are based on models for disease prevention. That is, these are minimum levels indicated to avoid conditions like Pellagra (caused by vitamin B3 deficiency), Beriberi (caused by vitamin B1 deficiency), or Rickets (caused by vitamin D deficiency), for example. Nutrient fortification of foods by law has mostly eradicated those conditions. But, as noted, minimum recommended amounts are not the amounts required for optimal health.

    The best multivitamin supplements therefore do not provide just 100% of a recommended daily amount of a certain nutrient, but far higher amounts. That is for truly optimal health, high-potency is a must in multivitamins. One of the main reasons for this is "biochemical individuality." While most people fall within a certain range in terms of their needs for a specific nutrient, the overall range (or bell curve) may be quite large. Your needs may be greater.

    Another, related reason is genetics. If you are heterozygous for a gene that requires a specific nutrient, then you may already be at a disadvantage for assimilating or processing it. If you are homozygous, then not having sufficient amounts of a nutrient can have much larger, adverse consequences.

    For any given nutrient, then, your needs may be higher or significantly higher than other people's needs. The best way to guarantee your needs are met is to ensure you consume larger amounts. That is, a high-potency multivitamin providing levels of nutrients well above the minimum amounts established to avoid deficiency.

    MULTIVITAMINS ARE SAFE, LOW COST,
    AND EFFECTIVE

    High-potency multivitamins work well because vitamins—at least at the levels we are talking about here—are non-toxic, safe, and well-tolerated. Add to the safety of vitamins their relatively low cost (especially compared to pharmaceuticals) that solidifies the case for high-potency multivitamins as a virtual "no-brainer" for supporting good health.

    That is the basic rationale for why you need a high-quality, high-potency multivitamin. There are many other reasons. Such reasons include the fact that diet alone is usually not enough to provide the levels of basic nutrients you need.

    DIET ALONE IS USUALLY INSUFFICIENT FOR OPTIMAL LEVELS OF NUTRIENTS

    Diet alone could perhaps be sufficient if foods were nutrient-dense and you consumed enough of them. But foods today are typically not nutrient-dense given how modern agriculture has stripped the soils of essential nutrients. Herbicides and pesticides then poison foods. And the widely used glyphosate herbicide (RoundUp) actually depletes nutrients in foods by blocking their uptake in plants leading to further depletion in crop foods. Food processing then strips out additional nutrients. Get the picture?

    On top of all this, your requirements for nutrients are increased by factors such as pollution and chemical exposures (and greater stress on detoxification organs), emotional stress, immune stresses (like fighting off colds or flu), and even free-radical stress caused by electromagnetic fields (EMFs) such as mobile phone and Wi-Fi exposures. In many cases, various stresses and environmental exposures put a greater burden on your antioxidant defense systems by subjecting you to free-radical attack. This is just the beginning.

    Assuming your diet were "perfect" (which most likely it is not), your needs for various nutrients will vary depending on your levels of exposure to stresses (emotional, chemical, electromagnetic, etc.). This means that as your needs for extra nutrients rise to combat these stresses, the simplest and best way to meet those needs is through consuming additional, supplemental amounts of nutrients—to successfully meet those needs. Otherwise, having only minimal amounts (i.e., daily values created to avoid deficiency diseases) means your need for higher amounts will not be met.

    IF YOU DO NOTHING ELSE, TAKE A HIGH-QUALITY MULTIVITAMIN

    A multivitamin can meet those additional needs, or at least start meeting them. In fact, a multivitamin is the best "first line of defense." In the HPDI system, a multivitamin is just one of six foundational supplements—but it "first among equals" and therefore the very first supplement we recommend. This means that if you do nothing else, then take a multivitamin.

    Need another good reason to make a multivitamin? Again, genetics. HPDI has teamed up with Bodysync, the developer of Nutrisync genetic tests (available to HPDI resellers on this website and to retail customers by phone) that offers testing for health-related genetic variations in your DNA.

    Among the first things we realized after analyzing Nutrsync genetic test results is that many genetic variants that may cause problems with uptake of certain nutrients—or that require additional amounts of nutrients—can be partly or wholly mitigated by taking a high-potency multivitamin. This is not true in every case, but surprisingly the nutrients provided in a quality multivitamin can be a strong defense in this regard.

    Another thing we noticed is that the results of almost everyone taking the Nutrisync test exhibit certain genetic weaknesses that would benefit from a multivitamin. Another "no brainer" observation that may not have been so obvious beforehand, yet which corresponds with what we have been recommending to clients for decades: Take a multivitamin!

    People may not realize that optimal health is within reach. Taking a high-potency multivitamin daily is a major first step toward achieving it.

    BENEFITS OF A HIGH-QUALITY, HIGH-POTENCY MULTIVITAMIN

    Considering all the factors involved in optimal nutrition—and how important nutrition is to health—it is remarkable to think that your health can be well maintained or dramatically improved simply by taking a high-potency multivitamin. Yet, that is a fact. And

    • Ensures complete nutrition by providing a wide-range of nutrients to supplement those obtainable by diet
    • Provides optimal levels of nutrients in a balanced way
    • Guards against deficiencies of particular nutrients
    • Protects against nutrient depletion caused by increased needs for nutrients (e.g., various stresses or periods of inadequate intake).
    • Helps you fulfill genetic potential by supplying nutrients required for optimal genetic expression and for overcoming adverse genetic factors
    • Safe, low cost, and effective means to support good health

    BENEFITS OF HPDI MULTIVITAMINS

    HPDI formulates and sells some of the highest-quality, high-potency multivitamins available. Many of our customers are health professionals who supply their clients with our multivitamins—because health professionals demand supplements proven to be effective. And they know the difference!

    HPDI multivitamins provide a complete range of nutrients, including vitamins, minerals, cofactors, and phytonutrients
    • Therapeutic levels of nutrients in amounts necessary for health—typically greater than daily values
    • Nutrients balanced so as not to provide too little or too much of any given nutrient
    • High-purity with minimal excipients, and avoidance of harmful excipients
    • Advanced forms  (including coenzyme vitamins) for optimal uptake, transport, and utilization
    • Inclusion of coenzyme form B vitamins
    • Inclusion of potent antioxidants and Nrf2 activators
    • Formulated by Hank Liers, PhD, designer of supplements for 30 years
    • Vegetarian capsules

    HPDI MULTIVITAMINS

    Health Products Distributors, Inc. (HPDI) currently offers five multivitamins, including Mighty Multi-Vite!, Multi Two (tabs and caps), Mini Multi, and Chewable Kids Mighty-Multi. Each multivitamin is formulated for a specific purpose:

    Multi Two and Mighty Multi-Vite! are flagship multivitamins with advanced forms. Multi Two offers higher levels of B vitamins, whereas Mighty Multi-Vite! provides relatively more antioxidants and phytonutrients. Mighty Multi-Vite! is a capsule, whereas Multi Two comes capsules and tablets.

    Mini Multi is formulated for chemically and environmentally sensitive individuals or those who seek ultra-high purity. Mini Multi contains no excipients (i.e., additives or fillers), and provides 100% coenzyme vitamins.

    Chewable Kids Mighty-Multi! tastes great and includes xylitol to prevent cavities. Kids love this chewable formula, but it is also scalable for adults. This formula is most similar to Mighty Multi-Vite! in terms its nutrient content.

    HPDI multivitamins HPDI multivitamins: Multi Two (caps and tabs), Mighty Multi-Vite!, Mini Multi, and Chewable Kids Mighty-Multi.

    HPDI MULTIVITAMINS IN DEPTH

    1. MIGHTY MULTI-VITE!

    HANK & BRIAN'S™ MIGHTY MULTI-VITE! (or as we often call it, the "Mighty Multi") is perhaps the premier HPDI multivitamin, and definitely among the flagship multivitamins we offer. I personally take this one most of the time. It is in the "Hank & Brian's" line, which generally are among our best products.

    Mighty Multi incorporates the latest nutritional research in a complete formula that combines the highest-quality, most assimilable forms of vitamins and minerals along with advanced herbal nutrition.

    Mighty Multi-Vite! is an advanced, cutting-edge multivitamin that is a leader within HPDI's line of foundational supplements. This formula exhibits superior performance with respect to supporting optimal health, and is among the world's most sophisticated multivitamins. Mighty Multi-Vite! works synergistically with other foundational supplements to help sustain maximum health, vitality, and promote longevity.

    Now with these 7 absolutely essential improvements:

    • Now in an ultra-pure vegetarian capsule
    • Vitamin B12 is now in the methylcobalamin coenzyme form
    • Turmeric is now in an extract form with 95% curcuminoids - a powerful Nrf2 activator
    • Now uses broccoli sprouts powder containing sulforaphane - another powerful Nrf2 activator
    • Contains both Vitamin K1 and Vitamin K2 (as MK-7)
    • Contains the best coenzyme form of folate - L-5-MTHF
    • Contains no magnesium stearate
    Mighty Multi multivitamins Mighty Multi-Vite! is an HPDI flagship multivitamin offering special nutrients for antioxidant protection.

    MIGHTY MULTI-VITE! BENEFITS

    COMPLETE, BALANCED ESSENTIAL NUTRITION – Provides a full spectrum of nutrients exceptionally well balanced for creating and maintaining optimal heatlh. Mighty Multi-Vite! offers all the most important vitamins along with minerals, cofactors, antioxidants, and herbs.

    RAPID, EASY ASSIMILATION – Incorporates the most bioavailable vitamin and mineral carriers most easily recognized and rapidly assimilated by your body. In addition,  the formula uses multiple forms of mineral carriers to ensure assimilation. In addition, the capsule form speeds uptake because it does not require time for the body to break it down (unlike tablets).  

    ENERGIZING – Includes coenzyme form vitamins and Krebs Cycle bionutrients that work with your body to create super high energy levels. Provides significant levels of B vitamins (especially coenzyme B vitamins) known for boosting energy, supporting the body during times of stress, nerve function, heart function, and for working together with dietary RNA (found in Rejuvenate!™ superfoods) to produce significant therapeutic effects.

    FOUNDATIONAL SUPPLEMENT – For creating health and establishing a complete supplement program. Providing excellent foundational nutrition, Mighty Multi-Vite! is designed to work synergistically with other foundational formulas for maximum health benefits.

    In addition to the newest improvements, Mighty Multi-Vite! features:

    • A full spectrum of B-complex vitamins, most in coenzyme forms, as well as more conventional forms. Includes Vitamin B1 as thiamin HCl and thiamin diphosphate, Vitamin B2 as riboflavin and riboflavin-5'-phosphate, Vitamin B3 as niacinamide and niacin, Vitamin B5 as pantothenic acid, Vitamin B6 as pyridoxine HCl and pyridoxal-5'-phosphate, folate as L-5-methyltetrahydrofolate (L-5-MTHF), Vitamin B12 as methylcobalamin, and biotin.
    • All of the most absorbable and usable forms of the fat-soluble vitamin group, including Vitamin A (as beta-carotene), Vitamin E (as d-alpha tocopherol succinate), Vitamin D-3 (as cholecalciferol), Vitamin K (as phytonadione and MK-7).
    • A complete and balanced supply of the most abundant carotenoids found in the body, including beta- and alpha-carotene, as well as lycopene and lutein.
    • A variety of the best-known herbal preparations, including quercetin, grape extract, turmeric (95% curcuminoids), broccoli sprouts powder, octacosanol from policosanol, and stevia.
    • All of the known essential minerals in forms readily absorbed and recognized by the body including calcium, magnesium, potassium, zinc, manganese, boron, copper, chromium, molybdenum, vanadium, and selenium.
    • Mineral carriers such as ascorbates, Krebs cycle bionutrients and amino acids providing the body with important metabolic substrates and vitamins, including citrate, succinate, alpha-ketoglutarate, fumarate, malate, glycinate, aspartate, sebacate, and Vitamin C.
    • Includes the important sulfur-containing amino acid N-Acetyl-L-Cysteine to support the body's antioxidant and detoxification systems and betaine HCl to support digestive processes.
    • Includes choline and inositol which play a crucial role in all of the cell membranes of the body, in brain function, and in liver function.
    • Exclusion of the prooxidant minerals of iron and iodine which can lead to excessive free-radical production and PABA that sometimes adversely affects brain function in some individuals. Note: we sell iodine as separate formulas.
    • Capsule form that ensures the maximum absorption of ingredients.
    • Four-per-day full dosage that allows for partial dosing for children, seniors, and pets.
    • Vegetarian formula - including capsule.
    • Capsule contents designed to smell and taste good to adults and children when emptied into smoothies, drinks, and foods. This allows greater flexibility of use.
    • Exclusion of ingredients such as wheat, gluten, dairy, corn, soy, and egg having well-known antigenic properties and that may be associated with allergy or delayed hypersensitivity reactions.
    • A minimum of excipients, fillers, lubricants, etc. having deleterious effects in some individuals. No GMOs.

    As I mentioned previously, the Mighty Multi is uniquely advanced it that it provides special antioxidant ingredients like turmeric, grape extract, and broccoli sprouts powder.

    2 & 3. MULTI TWO (CAPS & TABS)

    MULTI TWO is another HPDI flagship multivitamin. We recommend it especially for individuals who prefer more B vitamins built into their multivitamin. Yet, it offers somewhat fewer antioxidant nutrients.

    MULTI TWO is a pure, complete, biochemically formulated multivitamin supplement with minerals and cofactors. It dissolves readily and is highly bioavailable. All ingredients aresourced for purity and carefully selected to avoid common food allergens. MULTI TWO  is available in tablet and vegetarian capsule forms.

    MULTI TWO is among HPDI’s most popular multivitamins, providing top-notch quality, high-purity, advanced design and formulation, and exceptional value for the price.

    The formula comes in tablet or capsule forms. The tablet is suitable for vegetarians, only containing plant fiber to bind components, further eliminating chemical contaminants. The capsule form now is also vegetarian. The capsules have a four-per-day full dosage allowing for partial dosing for children, seniors, and pets. Note: the capsule's powder contents taste quite good to most people, so it can be added to sippy cups, blender drinks, smoothies, pet foods, etc.

    MULTI TWO is one of HPDI's foundational multivitamin supplements in our health recovery and maintenance programs. A foundational program of supplements includes a multivitamin, essential fatty acids, a Vitamin C formula, and a Rejuvenate!™ superfood.

    multivitamins Multi Two Caps are among HPDI's premier therapeutic-grade multivitamin formulas providing a complete range of nutrients.

    MULTI TWO OFFERS UNIQUE BENEFITS

    • COMPLETE, BALANCED FOUNDATIONAL NUTRITION. Full-Spectrum of Nutrients Exceptionally Balanced for Supporting Your Health. Foundational Formula Ideal for Providing Essential Foundational Nutrition. A high-quality multivitamin is the foundation (i.e., core) for a complete nutritional supplement program.
    • RAPID AND EFFECTIVE ASSIMILATION. Incorporates Bioavailable Vitamin and Mineral Carriers Your Body Recognizes and Can Assimilate Immediately. Plus, Multiple Carriers Ensure Assimilation. Tablet or Capsule Forms Rapidly Assimilated.
    • POWERFULLY ENERGIZING. Includes Coenzyme Form Vitamins and Krebs Cycle Bionutrients that work with your body to create high energy levels. Full-Spectrum Essential Nutrients Needed For Building, Supporting, and Maintaining Excellent Health.
    • HIGH PURITY. One of the Purest Available Supplements. Carefully Designed To Exclude Common Allergens, and Exclude or Minimize Excipients, Additives, and Fillers.
    • TABLET AND VEGETARIAN CAPSULE FORMS. We Offer Both Forms Giving You More Choice. Take Your Pick.
    • FOUNDATIONAL SUPPLEMENT. Providing solid foundational nutrition, MULTI TWO functions most effectively when used in conjunction with other foundational formulas, especially Vitamin C formulas (including ULTIMATE PROTECTOR™ and  PRO-C™), Essential Fatty Acid formulas (including Omega Plus and Essential Fats Plus E), and REJUVENATE!™ superfoods. These foundational supplements together form the foundation of a complete nutritional supplement program. From here, you can add additional  supplements (enhancements and specific condition formulas) addressing your individual needs, i.e., by pinpointing where your body requires additional nutritional support.

    MULTI TWO FEATURES

    • A full-spectrum of B-complex vitamins, most in coenzyme forms, as well as more conventional forms. Includes Vitamin B1 as thiamin HCl and thiamin diphosphate, Vitamin B2 as riboflavin and riboflavin 5’-phosphate, Vitamin B3 as niacinamide and niacin, and Vitamin B6 as pyridoxine HCl and pyridoxal 5’-phosphate, folate from calcium folinate and 5-MTHF, Vitamin B12 as methylcobalamin and hydroxocobalamin, and biotin.
    • All of the most absorbable and usable forms of the fat-soluble vitamin group, including Vitamin A (as natural beta-carotene), Vitamin E (as d-alpha tocopherol succinate and mixed tocopherols), Vitamin D3 (as cholecalciferol), and two forms of Vitamin K (K1 as phylloquinone and K2 as menaquinone-7).
    • Effective herbal preparations, including quercetin, grape extract, octacosanol.
    • All of the known essential minerals in forms readily absorbed and recognized by the body including calcium, magnesium, potassium, zinc, manganese, boron, copper, chromium, molybdenum, vanadium, and selenium.
    • Mineral carriers such as ascorbates, Krebs cycle bionutrients, and amino acids providing the body with important metabolic substrates and vitamins, including citrate, succinate, alpha-ketoglutarate, fumarate, malate, glycinate, aspartate, sebacate, and Vitamin C.
    • Includes betaine HCl to support digestive processes.
    • Choline and inositol which play a crucial role in all of the cell membranes of the body, in brain function, and in liver function.
    • Exclusion of the prooxidant minerals of iron and iodine which can lead to excessive free-radical production and PABA that sometimes adversely affects brain function in some individuals.
    • Four-per-day full dosage of capsule form allows for partial dosing for children, seniors, and pets.
    • Tablet and capsule forms are vegetarian (except for pharmaceutical glaze on tablets).
    • Exclusion of ingredients such as wheat, dairy, corn, soy, and egg having well-known antigenic properties and that may be associated with allergy or delayed hypersensitivity reactions. Contains no GMOs.
    • A minimum of excipients, fillers, lubricants, etc. that exert deleterious effects in some individuals.

    Multi Two is a great multivitamin and in many ways similar to the Mighty Multi-Vite!. However, Multi Two provides more B vitamins and in the case of certain B vitamins, it provides twice as much as Mighty Multi-Vite!. For anyone who requires plenty of B vitamins and who doesn't necessarily want to take a separate, standalone B vitamin formula, Multi Two is an ideal multivitamin.

    For more information, see the full Multi Two product page (capsules) or the Multi Two product page for tablets.

     

    4. MINI MULTI

    We call our Mini Multi the "World's Purest Multivitamin." This is because it was originally formulated for chemically and/or environmentally sensitive persons. The capsule is smaller than our other multivitamins which easily allows for partial dosing. It also is our only all coenzyme form multivitamin.

    MINI MULTI is an ultrapure, biochemically formulated, complete multivitamin supplement that includes essential and trace minerals, and cofactors. MINI MULTI is highly bioavailable and contained in a preservative-free veggie capsule (helping eliminate chemical contaminants). The capsule contains no fillers, flow agents, or any other excipients. Each component is the highest purity.

    MINI MULTI is ideal for chemically and environmentally sensitive individuals who require ultra-high purity supplements. The formula is designed by Dr. Hank Liers, who developed it as a ultra-pure formula for sensitive individuals. Yet, anyone can take MINI MULTI to benefit from its ultra-high purity and avoidance of additives, fillers, or other excipients.

    Many individuals who take MINI MULTI are not chemically sensitive, but suffer from allergies, sensitive digestive tracts, wish to avoid gelatin capsules, or simply do not enjoy swallowing large capsules (or tablets).

    multivitamins Meet Mini Multi, the world's purest multivitamin formulated originally for chemically and environmentally sensitive persons.

    ADVANCED DESIGN INCLUDES NEARLY 100% COENZYME FORM B VITAMINS

    MINI MULTI’s biochemical formulation incorporates the latest research on nutrient transport and interaction to enhance efficient metabolism and includes coenzyme forms of vitamins. The vitamins and minerals in MINI MULTI activate the body’s metabolic machinery, and synergistic cofactors aid absorption, assimilation, utilization, and metabolism of nutrients.

    MINI MULTI is among the first multivitamins to provide almost all coenzyme form B vitamins (i.e., all except vitamin B3, which we include as niacinamide). Coenzyme form vitamins are the natural forms best recognized and utilized in the body. For example, MINI MULTI provides folate in the form of folinic acid (a natural form of folate) from calcium folinate and L-5-MTHF (another natural form of folate), rather than the typical and commonly used folic acid, a synthetic form requiring enzymatic processing in the body for utilization. That is, coenzyme vitamins are easier to assimilate (especially for older individuals or those with health conditions that reduce enzyme activity in vivo) and they are immediately recognized and used in the body.

    FEATURES AND BENEFITS OF THE HIGHEST PURITY FORMULA AVAILABLE TODAY

    1. The world's purest multivitamin supplement, proven for more than a decade
    2. Ideal for chemically, environmentally or allergen sensitive individuals, or anyone desiring an ultra-high purity in a nutritional supplement
    3. Highly effective, complete formula includes vitamins, minerals, and cofactors (including powerful antioxidants)
    4. Includes nearly 100% coenzyme form B vitamins for rapid assimilation (all except B3 which is included as niacinamide and B5 which is included as pantothenic acid)
    5. Convenient four-per-day dosage allows easy for partial dosing
    6. Suitable for vegans and vegetarians (veggie capsule)
    7. Suitable for children (i.e., capsule may be opened and emptied into drinks or food)
    8. No additives, fillers, flow agents, or any other excipients!
    9. Nothing artificial or synthetic!
    10. Gluten-free
    11. In fact, MINI MULTI does not contain wheat, rye, oats, corn, barley, gluten, egg, dairy, citrus, yeast, sugar, GMOs, wax, sulfates, phosphates (other than coenzymes), preservatives, fillers, binders, coatings, colorings, or artificial flavorings

    MINI MULTI exhibits superior design, technical sophistication, ease of use, and high perfomance. We suggest you try it whether you are sensitive to fillers or flow agents, suffer from allergies due to common additives, wish to avoid artificial ingredients, or simply want the purest multivitamin available.

    In this day and age when many individuals suffer from allergies to ingredient sensitivities, Mini Multi represents a choice for the ultimate in high-purity. No excipients means a cleaner supplement option for anyone who may need it.

    5. CHEWABLE KIDS MIGHTY-MULTI

    HPDI's KIDS MIGHTY-MULTI! is truly one-of-a-kind. It is most similar to the Mighty Multi-Vite! in terms of the nutrients it provides, including antioxidants. However, it is our only chewable and it tastes great.

    KIDS MIGHTY-MULTI! is an advanced chewable multivitamin for children incorporating the latest nutritional research in a tasty, complete formula combining the highest-quality and most usable forms of vitamins, minerals, herbs, and cofactors.

    Our children’s multivitamin formula provides optimal levels of basic essential nutrients and thereby is an ideal foundation upon which to build a complete nutritional supplement program. A high-quality multivitamin is the starting-point for building a program uniquely designed to suit to your child’s individual requirements.

    We offer KIDS MIGHTY-MULTI! as a "top-of-the-line” children’s formula that tastes great and produces exceptional results. This unique formula very effectively provides children with a solid foundation of nutrients for establishing, building, supporting, and maintaining excellent health during this critical period of their lives.

    COMPLETE FORMULA – the most complete children's formulas available! It provides a full-spectrum of essential nutrients needed for creating, supporting, and maintaining excellent health for your child. It includes natural coenzyme form vitamins and Krebs cycle bionutrients that work with young bodies to provide energy for metabolic processes, healing, and optimal heatlh.

    AMAZING TASTE, NATURALLY  the most delicious kids multivitamin you'll ever taste! Flavored with only healthy, natural sweeteners and functional taste enhancers, including mannitol, xylitol, fructooligosaccharides (FOS) (from chicory root), natural fruit flavor, and stevia leaf extract. Most of these taste enhancers actually exhibit other positive benefits in the body (i.e., prebiotic effects, cavity prevention, and antioxidant action). Kids (and adults) love the taste!

    BALANCED ESSENTIAL NUTRIENTS  exceptionally balanced nutrients for supporting your child’s health. This is a foundational formula ideal for providing basic nutrients for health. Indeed, a high-quality multivitamin is a basic foundational formula (along with vitamin C and essential fatty acid formulas) in a nutritional supplement program. Our kids' formula puts your child on the nutritional track he or she deserves right from the start!

    "ULTRA PURE"
    – excludes common food source allergens (like wheat, corn, soy, or dairy). Also excludes unnecessary excipients, fillers, binders, and additives. Unlike many children’s vitamins, ours contains NO artificial colorings or flavorings, artificial sweeteners (like aspartame, saccharin, or sucralose) or hydrogenated vegetable oils...substances that can have deleterious effects on health (yet are frequently include. Plus, NO sugar and NO GMOs!

    RAPID ASSIMILATION
     – incorporates bioavailable vitamin and mineral carriers the body recognizes and can assimilate immediately. Plus, multiple carriers ensure assimilation. Chewable form speeds uptake in the body.

    FOUNDATIONAL FORMULA – forms the foundation of a complete supplement program for your child. Formulated to work with other foundational formulas, including Vitamin C formulas (like PRO-C™) and essential fatty acid formulas (like Essential Fats plus E) that  together form the basis of a complete nutritional supplement program. You can also add specific supplements addressing your individual needs of your child, i.e., by pinpointing where he or she may require additional nutritional support. Such specific supplements might include Allergy Support Plus, Joint Health Formula, or Ultimate Protector™ (super antioxidant & Nrf2 activator formula).

    Kids Mighty-Multi is the perfect multivitamin for kids offering appropriate levels of a wide range of important vitamins, minerals, cofactors, and antioxidants.

     KIDS MIGHTY-MULTI! FEATURES

    • A full-spectrum of B-complex vitamins primarily in coenzyme forms, including Vitamin B1 (as thiamin diphosphate), Vitamin B2 (as riboflavin-5’-phosphate), Vitamin B3 (as niacinamide and niacin), Pantothenic acid), Vitamin B6 (as pyridoxal 5’-phosphate), folate (as 5-MTHF), Vitamin B12 (as methylcobalamin), and Biotin.

    • All of the most absorbable and usable forms of the fat-soluble vitamin group, including Vitamin A (as natural beta-carotene), Vitamin E (as d-alpha tocopherol succinate and mixed tocopherols), Vitamin D3 (as cholecalciferol), and Vitamin K (as phylloquinone (K1) and MK-7 (K2)).

    • A complete and balanced supply of the most abundant carotenoids found in the body, including Beta-Carotene, Lycopene, and Lutein.

    • A variety of the best-known herbal ingredients, including Quercetin, Grape Extract, Turmeric extract, Broccoli Sprouts Powder, and Octacosanol (from policosanol).

    • Readily absorbed forms of all essential minerals, including Calcium, Magnesium, Potassium, Zinc, Iron, Manganese, Boron, Copper, Chromium, Molybdenum, Vanadium, and Selenium.

    • Easily assimilated mineral carriers, including ascorbates (Vitamin C), Krebs cycle bionutrients (citrate, succinate, alpha-ketoglutarate, fumarate, malate), and amino acids (e.g., glycine, taurine, and aspartic acid) that provide the body with important metabolic substrates and vitamins.

    • Sulfur-containing amino acids supporting the body’s detoxification systems.

    • Natural taste-enhancing complex of xylitol, mannitol, FOS, and stevia leaf extract. Tasty fruit flavor kids love!

    • Therapeutic levels of xylitol helping to prevent cavities.

    • Significant levels of choline and inositol that play a crucial role in all cell membranes, and in brain and liver function.

    • Betaine HCl to support digestive processes.

    • Exclusion of the pro-oxidant mineral iodine that may lead to excessive free radical production and PABA that can adversely affect brain function. We actually prefer the safer and more therapeutic Nascent Iodine over the forms normally found in vitamin formulas.

    • Exclusion of substances that have well-known antigenic properties and that may be associated with allergy or delayed hypersensitivity reactions, including wheat, corn, soy, egg, and dairy.

    • Minimum of excipients, fillers, or additives (that may have deleterious effects in some individuals).

    • Small tablet size allows for weight-dependent dosing (two tablets per 20 lbs body weight)

    MORE ABOUT KIDS MIGHTY-MULTI!

    A Better, Safer Multivitamin for Kids

    The vast majority of children's vitamins today are decidedly not advanced formulations. They typically provide only minimum amounts (i.e., no more than government mandated daily values) of vitamins, minerals, and other nutrients. In addition, most kids' vitamin on the market remain filled with sugars and artificial ingredients, including aspartame (a known toxin), artificial colorings, preservatives, hydrogenated oils, and other toxic substances.

    Consider what our Kids Mighty-Multi! does NOT contain: 

    • Aspartame. There is controversy surrounding this artificial sweetener, which is associated with a variety of neurological problems. In fact, there is widespread consensus that children under six should not use aspartame. We believe no one should consume aspartame at any age!
    • Refined sugars (usually listed as, sucrose, etc.). There is no place for sugar in multivitamins. Sugar in supplements is also dangerous because when coupled with ascorbic acid, it can damage teeth! Chewable kids vitamins containing sugar expose your child's teeth to double jeopardy.
    • Artificial dyes (FD&C Yellow, Blue, and/or Red). Artificial colors are associated with a wide range of health and behavioral problems. These include carcinogenicity, and contributing to learning problems like ADHD. In addition, FD&C Yellow dye #5 (tartrazine) is one of the main food triggers of asthma attacks.
    • Benzoates, sulfur dioxide, sulfites. These are bad because they are all preservatives that have no business being in a health supplement. They all are known to stimulate allergic reactions.
    • Hydrogenated oils. These are the bad, sticky fats that are found in junk foods and are harmful to your child's heart. Incredibly, some companies put hydrogenated oils in a children's vitamin!

    As you can see, our children's chewable multivitamin is not your ordinary kids multivitamin, and it provides all the benefits of our other multivitamins in a tasty chewable format. In fact, many adults take it who prefer a chewable over a capsule or tablet. It is uniquely formulated to be scalable for adults at the dosage of two tablets per 20 lbs body weight.

    multivitamins Chewable Kids Mighty-Multi tastes great, provides advanced forms of nutrients, and scales up for adults.

    CONCLUSION: TAKE A MULTIVITAMIN

    Multivitamins are the first supplement most people need and should take. Taking a high-potency, high-purity multivitamin daily provides many benefits beyond what you might expect. This includes everything from ensuring against deficiencies to providing amounts necessary for optimal health, and for compensating for greater needs depending on your unique biochemical individuality. Given the overarching safety and relatively low cost of multivitamins, they are best "first defense" in a nutrient-depleted world.

    HPDI offers four of the best multivitamins available anywhere, and five if you consider that Multi Two is available in capsules or tablets. So take your pick among them, and be the healthiest you can be.

    MULTIVITAMIN RESOURCES

    HPDI Multivitamins

    Mighty Multi-Vite!

    Multi Two (Capsules)

    Multi Two (Tablets)

    Mini Multi

    Kids Mighty-Multi! (Chewable)

    ARTICLES & e-BOOKS

    "Why You Need Foundational Supplements" 

    The Need for Foundational Supplements e-book (.pdf)

    "Rejuvenation Program Part Four"

    "Choosing Supplements for a Complete Nutritional Supplements Program"

    Benefits of Nutrigenomic Testing for Health

    Discovering Nutritional Needs Through Advanced Genetic Testing

    "No Deaths from Vitamins. None. Safety Once Again Confirmed by America's Largest Database" (Orthomolecular News Service, 2017)

    VIDEOS

    HPDI Foundational Supplements – VIDEO

    GENETIC TESTS

    Bodysync Testing Page for HPDI Resellers

  • THE TRUTH ABOUT ESSENTIAL FATTY ACIDS

    The Truth About Essential Fatty Acids

    Dr. Hank Liers, PhD essential fatty acidsMany in the field of nutrition have lost sight of the fact that there are two essential fatty acids needed by the body. Many people recommend omega-3 fatty acids assuming the the body gets sufficient omega-6 from the diet. The truth about essential fatty acids is more complicated. This article will show the more complete and correct picture.

    BACKGROUND

    Fatty acids are part of the lipids class, widely found in nature, food, and organisms. These fatty acids are a critical constituent of the cell membranes in all of the trillions of cells in the body. They have important biological functions including structural, communication, and metabolic roles, and they represent an important source of energy. Their metabolism produces a huge quantity of adenosine triphosphate (ATP). The beta-oxidation of the fatty acids is a well-known process, mostly used by the heart and the muscular tissue to obtain energy.

    Figure 1 below shows a schematic diagram of what a fatty acid looks like. One end of the structure in all cases has a carboxylic acid group (COOH) and the other end in all cases has a methyl group (CH3). Saturated fats have single bonds (-) between all carbon atoms (C), but unsaturated fats have a number of double bonds (=) between some of the carbon atoms.


    essential fatty acids Figure 1 - Basic diagram of fatty acids structure

    The human body can synthesize many of these fatty acids, except the essential fatty acids (PUFAs) linoleic acid (LA) and alpha-linolenic acid (ALA). These two are generally found in various vegetable oils, but their important metabolites are found mainly in special vegetable oils such as borage oil and in fish oils. Linoleic acid is the most abundant fatty acid in nature, and it is the precursor of other omega-6 fatty acids. Omega-3 fatty acids are synthesized from alpha-linolenic acid.

    Once ingested, short-chain PUFAs are converted to long-chain fatty acids. These are critical for mammalian cells in order to perform various biological functions, such as sustaining the structural integrity of cellular membranes and serving as signaling molecules. They are highly enriched in brain tissues, where they participate in the development and maintenance of the central nervous system during both embryonic and adult stages.

    Polyunsaturated fatty acids have been extensively researched. They include the essential fatty acids linoleic acid (an omega-6) and alpha linolenic acid (an omega-3). Omega-3s are not abundant in our food chain. There is none in corn oil and very little in soy oil, the two most widely used food oils. Therefore, nearly all the early research with polyunsaturated oils utilized omega-6 fatty acids, predominantly as linoleic acid.

    Fish oils were neglected out of ignorance or because the investigators chose to pass over these cholesterol-containing oils. Concern eventually developed over the close association between increasing incidence of mammary tumors and high intake of omega-6 polyunsaturated fatty acids. After some years, researchers finally turned their investigations to the interrelationship between dietary omega-6 and omega-3 fatty acids.

    FATTY ACID METABOLIC PATHWAYS

    The following diagram shows in detail the pathways for the production and use of fatty acids in the body. In the figure the metabolic pathways (running left to right) for four fatty acids types are shown (top - Omega-3, second - Omega-6, third - Omega-9, bottom - Omega-7). Notice that only the omega-3 and omega-6 oils are considered to be essential fatty acids because they cannot be made in the body. This means they must come from food.

    essential fatty acids Figure 2 - fatty acid metabolism pathways in the body

    The diagram shows a series of enzyme induced reactions that either add a double bond or two additional carbon/hydrogen pairs to the fatty acid. The enzymes that make this happen are called desaturase and elongase. The desaturase enzymes are given a number for the carbon number (that the enzyme is working on) from the methyl end of the fat. These same enzymes work on all of the fatty acid types. For example, Delta 6 desaturase causes an additional double bond to be inserted into both alpha-linolenic (omega-3) and linoleic acid (omega-6) (as well as oleic acid and palmitoleic acids).

    In this way, the body is able to produce a wide variety of fatty acids that have their own unique effects on biochemistry. Some of these are more important than others. In particular, the omega-3 essential fatty acid eicosapentanoic acid (EPA), the omega-6 essential fatty acid dihomo-gamma-linolenic acid (DGLA), and the omega-6 essential fatty acid arachidonic acid (AA) are precursors for a class of chemicals called eicosanoids/prostaglandins that have far reaching affects on key body functions.

    EICOSANOIDS/PROSTAGLANDINS

    Eicosanoids are prostaglandins that affect many aspects of health both positively and, in some cases, negatively. All known eicosanoids and prostaglandins are formed from the essential fatty acids linoleic acid (omega-6, or n-6), alpha linolenic acid (omega-3, or n-3), their "enhanced" derivatives, and from the omega-3 fatty acids in fish oils.

    Prostaglandins are short-lived highly active, hormone-like chemicals that are found in every cell of the body. They are regulators of cell activity and essential for maintaining health. Each cell type or organ produces its own form of prostaglandin to carry out its functions. There are three types of prostaglandins: PG1, PG2, and PG3.

    Series 1 Prostaglandins (PG1), derived from gamma-linolenic acid (GLA), the active component of borage oil, has many beneficial effects: It makes platelets less sticky, lowers blood pressure by relaxing smooth muscles in the walls of arteries, increases loss of sodium and water, decreases inflammation and enhances immunity.

    Series 2 Prostaglandins (PG2), also derived from GLA, is used in "fight or flight" (stress) situations, - the fight against danger, or the flight from it. In modern lifestyles which are high in stress but low in physical activity, continuous production of Series Two Prostaglandins results in sticky platelets, high blood pressure, increased water and sodium retention, increased inflammation and decreased immune system capabilities.

    Series 3 Prostaglandins (PG3), derived from eicosapentaenoic acid (EPA), the active component of fish oil, has beneficial effects. They block the detrimental effect of the Series 2 Prostaglandins, preventing them from being made in the body. As a result the platelets are less sticky, blood pressure is lower because the muscles in the walls of our arteries remain relaxed, loss of sodium and water by the kidneys takes place more effectively, inflammation response is decreased, and immune function is efficient.

    It is now known that the ratios of these dietary fatty acids are very important. Consumption of linoleic acid leads to production of the enhanced fatty acid, arachidonic acid (20:4n-6). Prostaglandins based on arachidonic acid exacerbate stress and inflammatory states, and suppress immunoprotective functions (i.e. resistance to disease). Too much linolenic acid and other omega-3s may cause excessive bleeding during injury, surgery, or childbirth. Large amounts of any of these unsaturated fatty acids in the diet without a compensatory increase in antioxidant nutrients (especially Vitamin E), can speed oxidative damage to tissues, resulting in accelerated aging while increasing the risk of degenerative diseases.

    Yet, a balanced ratio of both omega-3 and omega-6 fatty acids in the diet offers very positive health benefits. When omega-3 fatty acids predominate, the body will produce less arachidonic acid (20:4n-6). Immunity improves and inflammation subsides.

    Essential Fats

    Unfortunately, our Western diet has been almost devoid of omega-3 fatty acids. Creating the optimum intake of omega 3-to-omega 6 unsaturated fatty acids has become, therefore, an issue of prime importance for anyone concerned with health. We need to evaluate carefully the amounts of linoleic acid (n-6) we consume relative to our intake of alpha-linolenic acid (18:3n-3) and fish oils (EPA:20:5n-3 and DHA:22:6n-3).

    ESSENTIAL FATTY ACIDS - PATHWAYS

    The diagram in Figure 3 shows details of the omega-6 and omega-3 pathways. Pathway specifics indicate key eicosanoids (series 1 prostaglandins, series 2 prostaglandins, and series 3 prostaglandins), oil sources, and important nutrient cofactors that are needed for the reactions to take place.

    essential fatty acids Figure 3 - Essential Fatty Acids – pathways in the body

    The information is this diagram gives the clues we need in order to provide optimal types and amounts of omega-6 and omega-3. For example, I have chosen for my essential fatty acid product cold pressed borage oil as the best natural source of gamma linoleic acid (GLA). It contains 20% by weight — the highest amount found in natural oils.

    RESEARCH ON ESSENTIAL FATTY ACIDS

    Work by Chapkin et. al. (see references 1–4 below) has identified the potent synergistic relationship between GLA, an omega-6 fatty acid, and the well-known omega-3 fatty acids. Chapkin has shown that, rather than simply the quantity of dietary omega-3s, it is the ratio of omega-6 to omega-3 fatty acids that is important in achieving full cardiovascular health and inflammatory control.

    Furthermore, Chapkin has identified the ideal ratio. His published work deals with the importance of mixed diets supplying both linoleic and linolenic acids. To underscore the importance of these two fatty acids, refined oil supplements rich in enhanced forms were used. "Enhanced forms" are fatty acids derived from the original. They are one or more steps closer to the actual eicosanoid. In the human body, alpha linolenic acid (18:3n-3) is eventually converted to eicosapentaenoic acid (EPA, 20:5n-3) and linoleic acid (18:2n-6) is converted to gamma-linolenic (GLA, 18:3n-6) as its first enhanced form. Both enhanced fatty acids are precursors to eicosanoids.

    In Chapkin's research, superior health benefits were delivered by the mixed diet that supplied the eicosanoid precursors in a specific ratio. The balanced ratio of enhanced Omega-6 (GLA)-to-Omega-3 (EPA) fatty acids was 1:4.

    IMPLEMENTATION OF THE SCIENCE

    Based upon the science discussed above, I developed a product with the correct Omega-6 (GLA)-to-Omega-3 (EPA) ratio and with proper amounts. It is available to you as Hank & Brians Essential Fats Plus E from Health Products Distributors, Inc. (HPDI).

    Essential Fats Plus E

    ESSENTIAL FATS PLUS E IS A HIGHLY ADVANCED ESSENTIAL FATTY ACIDS SUPPLEMENT
    OFFERING SPECIAL BENEFITS:

    1. UNIQUE COMBINATION — Essential Fats (EPA, DHA, GLA) plus Vitamin E. This unique formula offers more than one type of Vitamin E (not just d-alpha-tocopherol) and balanced essential fats.
    2. BALANCED ESSENTIAL FATS— Many EFA supplements contain only omega-3s, but for optimal function the body requires a balance of omega-3 and omega-6 essential fats. In addition, our special formula provides a 4-to-1 ratio of EPA to GLA in order to achieve a balance you need for optimal health.
    3. FULL-SPECTRUM VITAMIN E — Tocotrienols and tocopherols in this formula are natural vitamin E substances derived from oryza rice bran oil and protect polyunsatured EFAs against free-radical damage both in the capsule and in your body. Many Vitamin E supplements contain only d-alpha tocopherol, which is only a single component of the full-spectrum Vitamin E in this formula.
    4. ULTRAPURE — Molecularly distilled oils of extremely high-purity containing no PCBs, heavy metals, or oxidized contaminants. Free of excipients, additives, and common food allergens!

    COMPOSITION: Six softgel capsules provides the following percentages of the Daily Value.

    NUTRIENT AMOUNT % Daily Value†
    EPA (Eicosapentaenoic Acid 20:5 omega 3)
    (from 2,000 mg of purified fish oils)
    360 mg *
    DHA (docosahexaenoic Acid 22:6 omega 3)
    (from 2,000 mg of purified fish oils)
    240 mg *
    GLA (Gamma Linolenic Acid 18:3 omega 6)
    (from 450 mg of cold pressed borage seed oil)
    90 mg *
    Vitamin E (d-alpha-tocopherol) (from 180 mg of Oryza rice bran oil) 24 IU 81%
    Mixed Tocotrienols (d-gamma, d-alpha, and d-delta)
    (from 180 mg of Oryza rice bran oil)
    28.8 mg *

    * No established Daily Value
    † Daily Values based on a 2,000 calorie diet

    IMPORTANT FUNCTIONS OF ESSENTIAL FATTY ACIDS

    Below we provide some of the functions and benefits obtained when by diet or supplementation the correct ratios and amounts of essential fatty acids are consumed.

    • Regulate steroid production and hormone synthesis
    • Regulate pressure in the eyes, joints, and blood vessels
    • Regulate response to pain, inflammation, and swelling
    • Mediate Immune Response
    • Regulate bodily secretions and their viscosity
    • Dilate or constrict blood vessels
    • Regulate smooth muscle and autonomic reflexes
    • Are primary constituents of cellular membranes
    • Regulate the rate at which cells divide
    • Necessary for the transport of oxygen from the red blood cells to tissues
    • Necessary for proper kidney function and fluid balance
    • Prevent red blood cells from clumping together
    • Regulate nerve transmission

    GENETIC TESTING AND ESSENTIAL FATTY ACIDS

    Please note that genetic testing for a wide range of genes and the enzymes they produce has indicated that essential fatty acids can be an important factor in helping the body overcome a variety negative gene variations. These negative gene variations include genes that relate to: 1) Inflammatory Response, 2) Exercise Performance, 3) Exercise Recovery, 4) Cardiovascular Fitness, 5) Body Composition, and 6) VO2 Max, Aerobic Capacity.

    We will discuss this more deeply in a future blog article.

    CONCLUSION

    The body is best protected from a range of health issues when we supply a mixed diet of both omega-3 and omega-6 essential fatty acids. Studies show that we do not need to consume large amounts of fatty acids if the ratio is correct. These findings indicate that, for a typical human body, amounts of 90 mg GLA (18:3n-6) to 360 mg EPA (20:5n-3) taken daily will provide for the optimum production of the three major prostaglandins. These amounts are found in Hank & Brians Essential Fats Plus E.

    REFERENCES

    The following includes abstracts of Chapkin's published research on essential fatty acids.

    REFERENCE 1

    Chapkin RS Somers SD Erickson KL

    Dietary manipulation of macrophage phospholipid classes: selective increase of dihomogammalinolenic acid.

    In: Lipids (1988 Aug) 23(8):766-70

    Because alterations in the dietary content of fatty acids are an important method for modulating macrophage eicosanoid production, we have quantitated the levels of n-6 and n-3 polyunsaturated fatty acids in peritoneal macrophage individual phospholipids from mice fed diets (3 wk) with either safflower oil (SAF), predominantly containing 18:2n-6, borage, (BOR) containing 18:2n-6 and 18:3n-6, fish (MFO) containing 20:5n-3 and 22:6n-3, and borage/fish mixture (MIX) containing 18:2n-6, 18:3n-6, 20:5n-3 and 22:6n-3. Dietary n-3 fatty acids were readily incorporated into macrophage phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylserine (PS) and phosphatidylinositol (PI). The increase in n-3 fatty acid levels was accompanied by a decrease in the absolute levels of 18:2n-6, 20:4n-6 and 22:4n-6 in PC, PE and PS. Interestingly, PI 20:4n-6 levels were not significantly lowered (P greater than 0.05) in MIX and MFO macrophages relative to SAF and BOR. These data demonstrate the unique ability of this phospholipid to selectively maintain its 20:4n-6 levels. In BOR and MIX animals, 20:3n-6 levels were significantly increased (P less than 0.05) in all phospholipids relative to SAF and MFO. The combination of borage and fish oils (MIX diet) produced the highest 20:3n-6/20:4n-6 ratio in all phospholipids. These data show that the macrophage eicosanoid precursor levels of 20:3n-6, 20:4n-6 and n-3 acids can be selectively manipulated through the use of specific dietary regimens. This is noteworthy because an increase in phospholipid levels of 20:3n-6 and 20:5n-3, while concomitantly reducing 20:4n-6, may have therapeutic potential in treating inflammatory disorders.

    Institutional address: Department of Human Anatomy School of Medicine University of California Davis 95616.

     

    REFERENCE 2

    Chapkin RS Carmichael SL

    Effects of dietary n-3 and n-6 polyunsaturated fatty acids on macrophage phospholipid classes and subclasses.

    In: Lipids (1990 Dec) 25(12):827-34

    This study examined the effects of n-3 and n-6 polyunsaturated fatty acid alimentation on murine peritoneal macrophage phospholipids. Mice were fed complete diets supplemented with either corn oil predominantly containing 18:2n-6, borage oil containing 18:2n-6 and 18:3n-6, fish/corn oil mixture containing 18:2n-6, 20:5n-3 and 22:6n-3, or fish/borage oil mixture containing 18:2n-6, 18:3n-6, 20:5n-3 and 22:6n-3. After two weeks, the fatty acid levels of glycerophosphoserines (GPS), glycerophosphoinositols (GPI), sphingomyelin (SPH), and of the glycerophosphocholine (GPC) and glycerophosphoethanolamine (GPE) phospholipid subclasses were determined. We found that mouse peritoneal macrophage GPC contain primarily 1-O-alkyl-2-acyl (range for the dietary groups, 24.6-30.5 mol %) and 1,2-diacyl (63.2-67.2 mol %), and that GPE contains 1-O- alk-1'-enyl-2-acyl (40.9-47.4 mol %) and 1,2-diacyl (44.2-51.2 mol %) subclasses. In general, fish oil feeding increased macrophage 20:5n-3, 22:5n-3 and 22:6n-3 levels while simultaneously reducing 20:4n-6 in GPS, GPI, GPE and GPC subclasses except for 1-O-alk-1'-enyl-2-acyl GPC. Administration of 18:3n-6 rich diets (borage and fish/borage mixture) resulted in the accumulation of 20:3n-6 (2-carbon elongation product of 18:3n-6) in most phospholipids. In general, the novel combination of dietary 18:3n-6 and n-3 PUFA produced the highest 20:3n-6/20:4n-6 phospholipid fatty acid ratios. This study demonstrates that marked differences in the responses of macrophage phospholipid classes and subclasses exist following dietary manipulation.

     

    REFERENCE 3

    Fan YY Chapkin RS

    Mouse peritoneal macrophage prostaglandin E1 synthesis is altered by dietary gamma-linolenic acid.

    In: J Nutr (1992 Aug) 122(8):1600-6

    The ability of dietary gamma-linolenic acid [18:3(n-6)] to modulate prostaglandin biosynthesis in mouse resident peritoneal macrophages was determined. Mice were fed diets containing corn oil, borage oil or evening primrose oil or a mixture of borage and fish oils. After 2 wk, resident peritoneal macrophages were isolated and stimulated with unopsonized zymosan to induce prostaglandin synthesis. Borage oil, primrose oil and fish-borage oil mixture dietary groups (containing 25.6, 11.9 and 19.5 g gamma-linolenic acid/100 g fatty acids, respectively) had significantly (P less than 0.05) enhanced prostaglandin E1 synthesis (39.7, 29.4 and 73.0 nmol prostaglandin E1/mg protein, respectively) compared with corn oil-fed (containing less than 0.1 g gamma-linolenic acid/100 g fatty acids) animals, which synthesized less than 0.1 nmol prostaglandin E1/mg protein. Borage oil- and fish-borage oil mixture-fed mice had the highest biosynthetic ratio of prostaglandin E1/prostaglandin E2 (E1/E2 approximately 0.2). Macrophages from borage oil-fed mice synthesized the lowest amount of prostacyclin (198.7 nmol 6-keto-prostaglandin F1 alpha/mg protein) compared with corn oil-, primrose oil- and fish- borage oil mixture-fed mice (379.7, 764.8 and 384.2 nmol 6-keto- prostaglandin F1 alpha/mg protein, respectively). In addition, borage oil-, primrose oil- and fish-borage oil mixture-fed mice had significantly (P less than 0.05) higher levels of dihomo-gamma- linolenic acid [20:3(n-6)] in membrane phospholipids (5.5, 3.5 and 5.7 mol/100 mol, respectively) relative to corn oil-fed mice (2.0 mol/100 mol).

     

    REFERENCE 4

    Fan YY Chapkin RS Ramos KS

    Dietary lipid source alters murine macrophage/vascular smooth muscle cell interactions in vitro.

    In: J Nutr (1996 Sep) 126(9):2083-8

    This study was conducted to compare the impact of dietary lipids on the ability of macrophages to modulate vascular smooth muscle cell (SMC) DNA synthesis in vitro. C57BL/6 female mice were fed six different diets (6 mice/diet) containing 10% fat from corn oil (CO), borage oil (BO), primrose oil (PO), fish-corn oil mix (FC, 9:1, w/w), fish-borage oil mix (FB, 1:3, w/w), or fish-primrose oil mix (FP, 1:3, w/w) for 2 wk. Peritoneal macrophages were isolated from these mice, stimulated with zymosan or vehicle, and subsequently co-cultured with naive mouse aortic SMC in the presence of 3H-thymidine to measure SMC DNA synthesis. In this co-culture system, macrophages were seeded on 25-mm culture inserts (upper chamber) and SMC were seeded on 35-mm culture dishes (lower chamber). The two cell types were separated by a semipermeable membrane with a 30-kD cut-off. When quiescent SMC were co-cultured with macrophages, only the PO and FP diet groups had significantly (P < 0.05) lower SMC DNA synthesis compared with the control CO group whose diet contained no gamma- linolenic acid (GLA) or (n-3) polyunsaturated fatty acids (PUFA). In contrast, when cycling SMC were co-cultured with diet-modulated macrophages, all dietary groups except for those fed FC had significantly lower (P < 0.05) SMC DNA synthesis relative to the CO group. Although the level of GLA in PO and BO diets was different (11.5 and 22.3 g/100 g fatty acids, respectively), these treatments exerted comparable inhibitory effects on SMC DNA synthesis. The FP treatment consistently exhibited the lowest SMC DNA synthetic profile among the six dietary groups irrespective of SMC growth conditions. These data suggest that BO and PO alone or in combination with fish oil influence macrophage/smooth muscle cell interactions in a manner consistent with favorable modulation of the atherogenic process.

    These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

    BOOKS

    1. Enig, Mary G. Know Your Fats: The Complete Primer for Understanding the Nutrition of Fats, Oils, and Cholesterol. Bethesda Press, 2000.
  • HPDI FOUNDATIONAL SUPPLEMENTS – VIDEO

    Fred Liers PhD foundational supplements nutritionDo you know HPDI has a foundational supplements system? And that HPDI's system of Foundational Supplements is part of the comprehensive HPDI supplements system?

    Foundational supplements are basic supplements providing essential nutrients that should be the "foundation" of everyone's daily regimen. They are the like the base of a pyramid in a complete nutritional supplement program.

    All six HPDI foundational supplements are designed to provide a complete range of essential nutrients to complement a healthy diet and lifestyle. They help ensure sufficient levels of nutrients necessary for good health. And they are the first supplements we recommend taking as part of a complete nutritional supplement regimen.

    Foundational supplements the cornerstone in the HPDI supplement system. That is, HPDI offers a three-tiered system of nutritional supplements: Foundational Supplements, Enhancement Formulas, and Specific-Condition Formulas. The three "tiers" combined represent a complete nutritional supplement program. When customized appropriately to meet the needs of individuals, the three tiers of nutritional supplements help create optimal health.

    You can visualize the HPDI supplement system as a cone or pyramid having a base of Foundational Supplements ascending toward an apex of Enhancement Formulas and Specific Condition Formulas.

    foundational supplements HPDI system pyramid cone The HPDI Supplement System includes six Foundational Supplements — four primary and two secondary — including multivitamins, vitamin C/antioxidants, essential fats, and Rejuvenate! superfoods.

    HPDI FOUNDATIONAL SUPPLEMENTS

    We recommend six basic types of foundational supplements. The six categories are: 1) multivitamin formulas, 2) vitamin C / antioxidant formulas, 3) essential fats, 4) high-RNA foods (Rejuvenate! superfoods), 5) gut health formulas, and 6) hydrogen formulas.

    We further break down the six foundational supplements into "primary" and "secondary" foundational supplements. The first four (listed above) being primary and the last two (gut health and hydrogen formulas) being secondary. This doesn't mean that gut health or hydrogen formulas are less essential, depending on the person. But typically we recommend the first four in order.

    We established the original three types of foundational supplements about 1988. We have always recommended multivitamins, vitamin C and antioxidants, and essential fats, as being the most important nutritional supplements for establishing and maintaining general health.

    We later added high-RNA foods (like Rejuvenate! superfoods) as a fourth type of foundational supplement because research indicates dietary nucleic acids are essential nutrients—see our many articles on dietary nucleic acids, Dr. Benjamin S. Frank, and about Rejuvenate! superfoods (Original Greens, PLUS, and Berries & Herbs).

    Two categories of foundational supplements were added more recently: gut health formulas (especially RESTORE) and hydrogen formulas. Hank wrote an article (Amending the HPDI Foundational Program) about these changes in April 2016. We added these two categories after much consideration regarding their benefits, and have written extensively about them (see Resources below).

    The entire HPDI supplement system is depicted (above) as a cone. The six types of foundational supplements form the base of the cone. Enhancement Formulas and Specific-Condition formulas sit above toward the apex.

    ultimate protector foundational supplements Ultimate Protector Nrf2 formula is a foundational supplement in the vitamin C / antioxidant category.

    FOUNDATIONAL SUPPLEMENTS: BEST PRACTICES

    I recommend using all six types of HPDI foundational supplements. I personally take the following supplements (below) and present them here as an example of how they can be integrated into a complete supplement regimen. Foundational Supplements I take:

    1. Multivitamin: Hank & Brian's Mighty Multi-Vite! (4 per day in divided doses)

    2. Vitamin C / antioxidants: PRO-C (6–8 per day) and Ultimate Protector Nrf2 activator (8–12 per day)

    3. Essential Fats: Essential Fats Plus E (4 per day)

    4. Rejuvenate!™ superfood: All three Rejuvenate! superfoods (2–8 scoops per day)

    5. Gut Health: RESTORE For Gut Health (1–2 ounces per day) and/or a soil-based probiotic (1–3 per week)

    6. Hydrogen: Megahydrate (2–6 per day), Active H2 tablets, or Vital Reaction Tablets (1–4 per day)

    (Note: HPDI Resellers, please call to order Vital Reaction Tablets)

    Taking one supplement from each of the six foundational supplement categories helps build, support, and maintain optimal health.

    We at HPDI recommend everyone take one of each type of foundational supplement. That is, we suggest an individual select for personal use a multivitamin, vitamin C/antioxidant formula, essential fats formula, Rejuvenate!™ superfood (or other high-RNA superfood), hydrogen product, and at least one gut health product (typically RESTORE) depending on their gut-health needs).

    Likewise, we suggest health care professionals recommend for their clients one of each of the six types of foundational supplements.

    The other two categories in the HPDI nutritional supplement system are Enhancement Formulas and Specific-Condition Formulas (see cone diagram). These are not foundational supplements. However, I include the supplements I take in these categories to show how Enhancement and Specific-Condition Formulas fully integrate with Foundational Supplements to form a complete supplement program providing not only essential nutrients required for health, but also particular nutrients required by me. This makes the system fully "customizable" to individual needs.

    Enhancement Formulas I take include: B-Complex-50 (B complex), Myo-Mag (magnesium/malic acid), Ubiquinol-50, Bone Guardian, and Vitamin D3 Plus.

    Specific Condition Formulas I take include: Joint Health Formula, Allergy Support Formula, Eye & Vision Formula, Intestinal Rejuvenation Formula, and Warrior Mist (pain topical), and Warrior Sleep (sleep topical).

    Thus, I take supplements from all three categories (Foundationals, Enhancements, and Specific-Condition) in the HPDI supplement system. However, I always prioritize foundational supplements—I take them first—because they are the all-important "base" on which my personal supplement program rests.

    Foundational supplements ideally are the base on which your supplement program—or those of your clients—rests, as well.

    We have seen the results of taking a complete set of foundational supplements. They work because the nutrients they provide are needed by everyone.

    foundational supplements multivitamin Muti Two Caps is a high-potency multivitamin with advanced forms for optimal utilization in the body.

    SYNERGY OF FOUNDATIONAL SUPPLEMENTS

    Individuals who use all six types of foundational supplements do best in terms of optimizing health. The reason is that all six foundational supplements provide nutrients required for good health.

    All six types of foundational supplement provide unique benefits. Yet, each performs functions required by the human body for good health. That is one reason when they are combined they exert synergistic effects for health going far beyond the benefits just using a few types of foundational supplements, depending on individual needs, of course.

    A SYSTEM OF FOUNDATIONAL SUPPLEMENTS IS NECESSARY

    Individuals benefit from a structured system of supplements that can be tailored to their needs. Otherwise basic nutrients may be left out from daily intake.

    For example, I know people who may or may not take a multivitamin. And they may or may not take vitamin C. Yet, they may take calcium for their bones, glucosamine for their joints, and lutein for their eyes. Or they may take a low-potency multivitamin providing merely the RDA for all nutrients.

    It is fine that individuals take supplements they regard as important or useful. But that does not guarantee that a wide range—and sufficient levels—of nutrients necessary for health are available to the body on a regular basis.

    In fact, I regard the supplement intake programs of most persons to be "hit-or-miss." They may consume nutrients important for a few functions in the body, yet fail to obtain other essential nutrients required for the nutrients they take to work most effectively. We have written extensively on this topic on our website and in blog articles (see below).

    Not taking regularly a complete set of foundational supplements likely means key nutrients (and key levels of nutrients) go missing. Over time, this means fewer and lower levels of nutrients available to support the body's needs for them at levels known to sustain the good health.

    The best way to ensure a sufficient range of nutrients at plentiful levels is to take foundational supplements. After a baseline of nutrients is established by taking foundational supplements, additional supplements can be added, as necessary. Following such a system and using it to customize a personal supplement regimen means there is a far better opportunity to obtain essential nutrients on a daily basis. And not to miss nutrients that help create optimal health.

    rejuvenate superfood foundational supplements High-RNA foods like Rejuvenate! PLUS superfood provide dietary nucleic acids important for health.

    A COMPLETE SUPPLEMENT SYSTEM INCLUDES FOUNDATIONAL SUPPLEMENTS

    After obtaining sufficient levels of basic nutrients required for health, then a person can add (or you can recommend) specific nutrients or formulas that target certain problems or issues. This is the basis for HPDI's creation of Enhancement Formulas and Specific-Condition Formulas.

    Nutritional supplements in the categories of Enhancement Formulas and Specific-Condition Formulas "stack" on top of HPDI's Foundational Supplements (see cone diagram above). In this way, a complete nutritional supplement program begins with the most essential nutrients and continues with customizations based on the unique needs of an individual.

    ENHANCEMENT FORMULAS

    Enhancement Formulas in the HPDI system are supplements we regard as falling into the next tier in terms of importance, at least for most people. They do not necessarily provide essential nutrients, and yet many people (including myself) benefit significantly from them.

    Enhancement Formulas include: magnesium formulas (topical and capsule), Vitamin D3 Plus, Nascent Iodine, Vitamin B12 (methylcobalamin), mushroom-based products (like Immune-Assist™), Prolyt (proteolytic enzymes), Digase (plant-based enzymes), and Warrior Mist (topical pain reliever), and many other formulas.

    SPECIFIC-CONDITION FORMULAS

    In the HPDI system, individuals can add (in a modular way) various formulas and single nutrients designed to support a particular set of needs or a target a specific condition.

    We offer a complete range of supplements (almost 100) including a range of supplements formulated to address specific conditions. These include Joint Health Formula, Eye & Vision Formula, Blood Sugar Support, Allergy Support, Prosta Plus, Intestinal Rejuvenation Formula, and many other formulas.

    ONE SYSTEM. THREE TIERS. HPDI NUTRITIONAL SUPPLEMENTS.

    HPDI Foundational Supplements collectively form the base tier of a complete nutritional supplement system comprised of three tiers: 1) Foundational Supplements (six types), 2) Enhancement Formulas (or simply "Enhancements"), and 3) Specific-Condition Formulas.

    Foundational Supplements are necessary because they provide nutrients foundational to health. Taking them daily or recommending your clients take them daily can help mean big differences in health, nutrition, and quality of life.

    We at HPDI design our nutritional supplements to be the most effective dietary supplements available. HPDI products are known for: 1) Advanced Formulation (including use of superior forms of nutrients), 2) Ultra-High Purity, 3) Avoidance of Harmful Ingredients, and 4) being made with Good Manufacturing Practices (GMP). For more details, please see The HPDI Difference and our Statement on Additives (Excipients).

    At least 40 of HPDI's products are formulated by Dr. Hank Liers. They fall in all categories in HPDI's supplement system. They can be found under "Dr. Hank Liers original formulas."

    foundational supplement EFA Essential Fats Plus E provides well-balanced omega-3 and omega-6 fatty acids.

    ADDENDUM: THE BODYSYNC GENETIC TEST & ACTION PLAN

    In recent years, genetic tests have become available that show gene variations can cause or predispose a person to serious conditions relating to important body functions such a lessened ability to process synthetic B vitamins (like folic acid), higher blood glucose levels, lower immune system function, and bone density problems relating to variants in the vitamin D receptor (VDR) gene, for example.

    We recommend a genetic test to determine whether individuals have certain gene variations impacting health. HPDI has teamed with a genetic testing company (BodySync, Inc.) and sells BodySync test kits on our Reseller site. Genes tested for in the Bodysync test include variations in genes impacting folate assimilation, cardiovascular health, detoxification, bone health, and more. Resellers can purchase the test kits directly from HPDI and retail customers can call us  (800-228-4265) to find out how we can help them get a test kit and support them with any associated counseling regarding the results.

    Genetic testing allows individuals to gain a clearer picture of where they may require additional or specific nutritional supplementation. In this respect, HPDI foundational supplements can play a significant role in providing the amounts and range of important nutrients that can help mitigate the adverse effects of certain gene variations in addition to diet, exercise, and lifestyle factors. After testing, you will receive a Bodysync Action Plan that makes recommendations for a healthy diet and lifestyle customized to your unique genetic profile.

    FOUNDATIONAL SUPPLEMENTS: FREQUENTLY ASKED QUESTIONS (FAQ)

    We frequently get questions from HPDI clients and resellers regarding foundational supplements. These questions include:

    "Why did you add gut health and hydrogen products to your foundational supplements program?"
    We found it necessary to add categories for gut health and hydrogen because they provide nutrients that are support the body and help ensure the foundational supplement system supports health most effectively. You can read more in previous blog articles (see below).

    "Which is the better multivitamin: Multi Two or Mighty Multi-Vite!™?"
    It depends on whether you need more B vitamins or antioxidants. Multi Two provides more B vitamins and Mighty Multi-Vite™ provides more antioxidants and cofactors. I take a separate HPDI B-Complex-50 formula, so I take Mighty Multi-Vite!™ as my primary multivitamin.

    "What are the differences between Rejuvenate!™ Original, PLUS, and Berries & Herbs superfoods?"
    They each provide about 340 mg of dietary nucleic acids. Original is the "greenest" with a large percentage of dietary nucleic acids coming from chlorella and spirunlina. PLUS is our most popular and 30% is identical to Original with more protein and a built-in multivitamin complex. Berries & Herbs contains no greens, yet more nucleic acids (390 mg), protein, and a built-in multivitamin. See our Rejuvenate! comparison page for more information.

    "Should I take a vitamin C formula with antioxidants like PRO-C or one with Nrf2 activators like Ultimate Protector?"
    Both provide vitamin C and Nrf2 activators, but Ultimate Protector provides more types of Nrf2 activators. Ultimate Protector capsules are smaller than PRO-C capsules, so a daily dose may require taking more capsules.

    "How important are hydrogen supplements?"
    Very important for energy production, recovery, antioxidant functions, and gut health. Hydrogen supplements like VR Tablets and Megahydrate ensure high levels of hydrogen are available in the body.

    What are your best products for supporting gut health?
    It depends on your needs: cleansing (Intestinal Rejuvenation Formula), probiotic/microbiome support, or tightening tight junctions in the gut (RESTORE)? We offer products for all these purposes. Typically, the first gut health formula we recommend is RESTORE because so many people require extra support for microbiome health and to restore gut integrity.

    These are just a few questions frequently asked about HPDI foundational supplements. If you need more information about products, please contact the HPDI office (800-228-4265) or email support@healthproductsdistributors.com.

    You can also contact Fred Liers, PhD or Hank Liers, PhD (formulator) with questions you may have regarding specific products, single nutrients, or formulation.

    SOURCES AND RESOURCES

    Foundational Supplements

    HPDI Full Product Overview

    The Need for Foundational Supplements (.pdf)

    The HPDI Difference (4 Pillars of Formulation)

    HPDI BLOG ARTICLES

    Amending the HPDI Foundational Supplements Program

    Foundational Supplements Remain Fundamental

    Vitamin C / Antioxidants

    PRO-C and Ultimate Protector Comparison

    Questions and Answers about Ultimate Protector

    The Amazing Healing Potential of Natural Nrf2 Activators

    Ultimate Protector™: First Impressions

    Ultimate Protector™ Brunswick Labs ORAC5.0™ Test Results

    Preventing Free-Radical Damage Using Ultimate Protector™

    Description and Comparison of ORAC Tests for Well Known Plant Ingredients and Ultimate Protector™

    Ultimate Protector and the Role of Foundational Supplements for Health

    Natural Phytochemical Nrf2 Activators for Chemoprevention

    New Directions for Preventing Free Radical Damage

    "Review of Scientific Research on Oligomeric  Proanthocyanidins (OPC)" by Dr. Hank Liers

    "Vitamin C - An Amazing Nutrient" by Dr. Hank Liers

    High-RNA Superfoods

    Rejuvenate! Berries & Herbs: Ingredients for Optimal Nutrition

    “9 Things to Know About Rejuvenate!™ Superfoods”

    “High-RNA Rejuvenate!™ Superfood”

    “Natural Phytochemical NRF2 Activators for Chemoprevention”

    Review of Scientific Research on Oligomeric Proanthocyanidins (OPC)

    DIETARY NUCLEIC ACIDS – DR. BENJAMIN S. FRANK, PART 1

    DIETARY NUCLEIC ACIDS – DR. BENJAMIN S. FRANK, PART 2

    Super-Tasty Morning Nutritional Drinks

    Hydrogen

    The Science Behind Megahydrate

    Hydrogen for Optimal Health

    Wonders of Molecular Hydrogen

    Gut Health

    Gut Health – Effects of Glyphosate and Antibiotics

    Gut Health – Intestinal Rejuvenation Formula

    PRODUCTS

    Vitamin formulas, including multivitamins

    Rejuvenate!™ Berries & Herbs

    Rejuvenate!™ PLUS

    Rejuvenate!™ (Original)

    Rejuvenate! Superfoods: Product Comparison

    Ultimate Protector™ Nrf2 Activator (vitamin C/antioxidant)

    PRO-C™ (Vitamin C/Antioxidant formula)

    Essential Fats Plus E

    Intestinal Rejuvenation Formula (gut health)

    Restore For Gut Health (lignite formula)

    Active H2 (hydrogen)

    Megahydrate (hydrogen)

    Prescript-Assist™ (probiotic/prebiotic)

    HPDI FOUNDATIONAL SUPPLEMENTS

  • BONE FRACTURES SUPPORT

    Dr. Hank Liers, PhD bone fracturesSeveral years ago a customer asked me for a program that could be helpful to those suffering with bone fractures. A relative had been diagnosed with multiple bone fractures in his ankle.

    Since I have been counseling individuals regarding natural treatments for supporting those with bone fractures and injury for many years, and was able to provide a comprehensive program that could be helpful in recovery. More recently, we have introduced products and tools that can be even more supportive. Therefore, in this article we are providing an update to the bone fractures program.

    Clearly, the need for such a program is great. According to the American Academy of Orthopaedic Surgeons (AAOS), about six million individuals suffer fractures each year in North America. In about 5–10 percent of cases, patients suffer either delayed healing or fractures that do not heal.

    The problem of bone fractures is especially troubling for the elderly, many of whom suffer from osteoporosis, a condition in which bones become weak and break more easily. For an older person, a fracture affects quality of life because it significantly reduces function and mobility, and requires an extended period of recuperation.

    The bone fracture program set forth below also works well to support the healing of other types of bone problems, including broken bones, bone surgery, osteoporosis, and wisdom tooth removal.

    THE BONE FRACTURE PROGRAM

    IMPORTANCE OF FOUNDATIONAL SUPPLEMENTS

    The first element of the program consists of Foundational Supplements. This group of supplements ensures the body is being supplied with all of the basic elements needed for optimal function. The primary foundational supplements consists of 1) a therapeutic multivitamin and mineral formula, 2) a complete buffered Vitamin C with antioxidants formula, 3) an essential fatty acids supplement, and 4) a high-RNA superfoods formula.

    Our Foundational Supplements are described in great detail on the HPDI website where we provide a free downloadable e-book "The Need for Foundational Supplements" (.pdf). Suffice it to say that the foundational supplements are a essential part of the program that ensure healing will take place quickly and effectively. I encourage everyone to become familiar with this information as foundational supplements are basic to any wellness or healing program.

    bone fractures

    ENHANCEMENT FORMULAS ARE CRITICAL FOR HEALING BONE FRACTURES

    The second element of the program for healing bone fractures consists of Enhancement Formulas that strengthen the body as it relates to dealing with the damaging effects of bone fractures. These include a Vitamin D3 formula with the synergistic nutrients of Vitamin A and Vitamin K2 that are required for the rebuilding of bone as well as strengthening the body in many other ways. The HPDI Vitamin D3 Plus formula to designed to specifically address this need.

    A second Enhancement Formula in this program is our comprehensive Bone Guardian formula that is based upon micronized veal bone that provides hydroxyapatite (Ca10(PO4)6(OH)2). Hydroxyapatite is the basic component of human bone that is 50% by volume and 70% by weight. Whereas the Vitamin D3 Plus formula builds the bone matrix, the Bone Guardian fills in the matrix with materials such as calcium, phosphorus, magnesium, boron, zinc, manganese, copper, silica, and strontium. HPDI sells Bone Guardian in both the tablet and capsule forms. The capsule form may be better for older people who are able to absorb capsules better than tablets.

    A third Enhancement Formula to the program is additional amounts of Vitamin C. Vitamin C is known to participate in every step of the process of building collagen, which is a key component of bone. Vitamin C has been shown to increase bone mass density. We recommend slowly increasing your intake of buffered Vitamin C until you reach your bowel tolerance. This can be accomplished by increasing your intake of HPDI's foundational supplement PRO-C™ formula. The PRO-C has the added value of containing oligomeric proanthocyanidins (OPCs) from grape seed, skin, & pulp. OPCs in the body are able to strongly crosslink and strengthen new and damaged collagen fibers needed needed to repair bones, ligaments, tendons, and cartilage.

    SPECIFIC CONDITION FORMULAS TARGET BONE FRACTURES

    The third element in the program are Specific Condition Formulas that directly address issues related to bone fractures. The first of these is the addition of a joint formula that allows the body to build and repair connective tissue and to significantly reduce inflammation in the area of bone fractures. In most cases of fractures there will be damaged ligaments and tendons as well as inflammation in the area.

    HPDI's Joint Health Formula includes the ingredients glucosamine hydrochloride, MSM, and sea cucumber (a significant source of chondroiten sulfate) in addition to anti-inflammatory substances such as turmeric extract, rutin, and grape extract (seed, pulp, and skin) that have been extremely helpful in both repairing connective tissue and reducing pain and inflammation.

    A second strongly recommended condition-specific formula is proteolytic enzymes. Because it is highly likely in the case of bone fractures and injury that there is significant tissue damage, a formula with pancreatic and plant enzymes as well as anti-inflammatories can be extremely helpful is clearing out the damaged tissue. This gives the body the opportunity to begin the rebuilding process much sooner.

    Our recommended PROLYT formula contains the proteolytic enzymes bromelain, trypsin (pancreatic enzyme), and chymotrypsin (pancreatic enzyme), and the polyphenols/bioflavonoids turmeric extract (95% curcuminoids), quercetin and oligomeric proanthocyanidins (OPCs) from grape extract. This formula when taken on an empty stomach between meals is quickly absorbed into the bloodstream and goes to work cleaning up any damaged tissues in the area surrounding a fracture and assists in reducing pain and inflammation.

    TOPICAL MAGNESIUM CHLORIDE FOR PAIN AND RAPID HEALING

    A final Specific Condition Formula that I highly recommend for healing bone fractures is to rub Ancient Minerals Magnesium Oil on and surrounding the fracture area. Bones cannot heal without having adequate amounts of magnesium available. Unfortunately, many people are deficient in magnesium and even taking oral magnesium cannot easily provide sufficient amounts to an area with a bone fracture. Magnesium oil (mostly magnesium chloride) is quickly absorbed transdermally (via skin) and often can provide rapid healing and pain relief!

    BODY pH COULD BE A FACTOR IN HEALING BONE FRACTURES

    The processed food diets with a high protein and low vegetable content consumed by many people in the U.S. and elsewhere often produce conditions in the body of acidity. This in turn leads to decreased oxygenation of cells and encourages a greater amount of anaerobic processes in metabolism. In addition, when the body is acidic calcium can be taken from bones in order to balance the acidity. This can lead to poor healing of bone fractures.

    In order to counter acidic conditions in the body we recommend the use of HPDI's pH ADJUST formula. As a dietary supplement, take 1 gm (about a rounded ¼ tsp) in 4-8 ounces of purified water preferably away from food, or as directed by a health care professional.  For extremely acidic conditions, try 4–10 doses per day, depending on acidity level. Use pH paper to ensure pH levels remain balanced, and do not become too alkaline (alkalosis may occur above pH 8.2).

    TESTING pH LEVELS: The best way to test pH levels is to use litmus paper, which HPDI offers in rolls (Hydrion brand) for this purpose. You can test salivary or urinary pH. In order to test salivary pH, simply use a small strip of pH paper to dip into a small amount of saliva. Advantages of pH paper include rapid results, ease of use, and cost effectiveness.

    pH Paper bone fractures protocol

    The color of the litmus paper indicates the pH level of the body fluid tested. Most litmus paper comes with an indicator chart showing colors corresponding to various pH levels. Alkaline states will generally produce a dark green, blue or purple color (most basic). Acidic states will range from yellow (most acidic) to light green.

    Salivary pH and urinary pH are significantly affected by recent food consumption and other factors, so it it best to test pH hours after meals or in the morning when you awake. We prefer to measure urinary pH since results are more consistent. Measuring urinary pH is a simple as placing a few drops of urine on the paper or dipping the paper into a sample cup of fresh urine.

    A consistent pH measurement of less than 7.0 indicates that you are too acidic (values less than 6.2 show extreme acidity). This indicates that you should consume more alkaline forming foods (usually vegetables) and/or take pH ADJUST. A single dose of pH ADJUST can change conditions in the body from acidic to alkaline within a few hours.

    GENETIC VARIATIONS IN YOUR VITAMIN D RECEPTOR GENE (VDR) MAY BE AN IMPORTANT FACTOR

    The VDR gene (contained in every cell of the body) provides instructions for making a protein called vitamin D receptor (VDR), which allows the body to respond appropriately to vitamin D. This vitamin can be acquired from foods in the diet or made in the body by exposure to from sunlight. Vitamin D is involved in maintaining the proper balance of several minerals in the body, including calcium and phosphate, which are essential for the normal formation of bones and teeth. One of vitamin D's major roles is to control the absorption of calcium and phosphate from the intestines into the bloodstream. Vitamin D is also involved in several process unrelated to bone formation.

    VDR attaches (binds) to the active form of vitamin D, known as calcitriol. Calcitrol is produced in the body from Vitamin D3 (cholecalciferol) in the liver and kidneys. The interaction with calcitriol allows VDR to partner with another protein called retinoid X receptor (RXR). The resulting complex of proteins then binds to particular regions of DNA, known as vitamin D response elements, and regulates the activity of vitamin D-responsive genes. By turning these genes on or off, VDR helps control calcium and phosphate absorption and other processes.

    In recent years, genetic tests have become available that show VDR variations can cause serious conditions related to low bone density and other important body functions such a higher blood glucose levels or lower immune system function. If a person is having little success in healing bone fractures, it is possible that VDR variations are a key factor of causation.

    In such cases, we recommend having genetic testing done to determine if VDR variations are present. Recently, HPDI has teamed with a genetic testing company (BodySync, Inc.) and sells the BodySync test kits on our Reseller site. Among the genes tested for in the test are three variations of the VDR gene. Resellers can purchase the test kits directly from HPDI and retail customers can call us  (800-228-4265) to find out how we can help them get a test kit and support them with any associated counseling regarding the results.

    SUGGESTED SUPPLEMENT SCHEDULE – BONE FRACTURES

    I have included all of the above supplements including recommended dosages plus more related to having an excellent diet in the table provided below.

    Description AM Noon PM Night Comments
    PRO-C 2 caps 2 caps 2 caps Take with meals or with snack.
    Bone Guardian 

    Bone Guardian Caps (easier to absorb)

    3 tabs

    3 caps

     

    3 caps

    3 tabs

    3 caps

    Take with meals.

    Take with meals.

    Mighty Multi-Vite! or
    Multi Two -- Multivitamins
    2 caps or
    1 tab
    2 caps or
    1 tab
    Take with meals.
    Essential Fats plus E 2 softgel 2 softgel 2 softgel Take with meals.
    PROLYT - Proteolytic Enzyme Formula 2 caps 2 caps 2 caps 2 caps Take between meals.
    Buffered Vitamin C, Tablets -- 1,000 mg (1 gm) or Powder (1/4 tsp = 1 gm) 2 tabs or
    1/2 tsp
    2 tabs or
    1/2 tsp
    2 tabs or 1/2 tsp 2 tabs or 1/2 tsp Best with meals, but other times are okay. Start with 2 tabs or 1/2 tsp twice per day and add another 2 tabs or 1/2 tsp every few days until you are taking 8 tabs or 2 tsp per day.
    Vitamin D3 Plus 5,000 IU 1 softgel 1 softgel Take with meals. Reduce to 1 softgel after 2 months.
    Joint Health Formula 2 caps 2 caps 2 caps Take between meals and away from Bone Guardian.
    Magnesium Oil 10 pumps 10 pumps 10 pumps 10 pumps Spray on affected area – or nearby area.
    Rejuvenate! Plus or
    Rejuvenate! (original)
    1 scoop 1 scoop Take as a meal by itself or with fruit/berries.

    ADDITIONAL NUTRIENTS FOR BONE FRACTURES

    Additional nutrients that may be helpful include pH ADJUST (to balance excess acidity in the body),  Warrior Mist™ for pain relief (rub on adjacent area several times daily), Echinacea (as drops or capsules), N-Acetyl-L-Cysteine - NAC (2 gms per day), Progesterone Cream - for women (1/4–1/2 tsp twice daily), and Prescript-Assist™ probiotics (2 capsules daily) if on antibiotics.

    PROPER DIET IS ESSENTIAL

    Consume a diet that provides good amounts of protein which is needed by the body to support the healing of bone fractures. Eat meats, poultry and fish (e.g., sardines, salmon, mackerel) in the amount of a 5–10 ounces per day. Ensure a good intake of organic vegetables, including high levels of dietary fiber. Drink 16 oz per day of fresh vegetable juices from carrot, celery, beets, cabbage, etc.

    Other healthy foods (preferably organic) include fruits, whole grains (e.g., brown rice, millet, and quinoa), beans, nuts and seeds (sunflower, chia, flax, pumpkin, almond, walnut and sesame in small amounts — 2 or 4 ounces — are good). Try eating Hank's Vegetable Soup several times a week. Avoid all sweets (sugar), processed/refined foods (white bread and pasta), preservatives, and artificial flavors and colors. Vary your diet.

    HYDROTHERAPY (WATER THERAPY) FOR BONE FRACTURES

    An additional treatment that can be useful is hydrotherapy. In particular, hot and cold showers are a very effective way to move the blood and create circulation. This can speed up both detoxification and delivery of healing nutrients to the area of a bone fracture. Here's how to do this. Once daily, take a complete hot and cold shower. You will start with hot water for one minute, then cold for one minute. Repeat this seven (7) times so the shower should last about 15 minutes.

    Another time, daily, you can perform a complete hot and cold shower routine again or a partial one just applying the water directly to or near the area where there is a bone fracture. While you are doing both hot and cold showers, pay special attention to any affected area and massage it as vigorously as is safe and comfortable. If a shower is impossible, then alternate hot packs and ice packs on the area of the bone fracture.

    BONE FRACTURES – CONCLUSION

    By following the recommendations and suggested supplement schedule, healing time for bone fractures can be significantly reduced and fractures may heal more completely with fewer complications. By ensuring your body receives the proper nutrients it needs to heal itself, and by engaging in other relevant practices (e.g., hydrotherapy), you and/or your loved ones may be able to deal with bone fractures successfully, and continue a healthy, vibrant lifestyle.

    ADDITIONAL RESOURCES

    REJUVENATION PROGRAM PART 6 (INCLUDES HYDROTHERAPY)

    REJUVENATE!™ SUPERFOODS

    ULTIMATE PROTECTOR™

    "FRED'S FAVORITE VEGETABLE JUICE RECIPE: 'THE DOCTOR'"

  • HOMOCYSTEINE GENETICS – COENZYME B VITAMINS

    Dr. Hank Liers, PhD homocysteine coenzyme B vitaminsWe previously published an article titled FOLATE INGREDIENTS – FOLINIC ACID & 5-MTHF in which we discuss how coenzyme folate vitamins are far superior to the synthetic folic acid form. In today's article, I take a more in-depth look at how homocysteine is formed from methionine, how genetics affects the metabolic pathways, and how B vitamins are used in metabolic pathways.

    One way to look at the metabolic pathways of methionine (an essential amino acid) is that it provides a way for the body to convert this sulfur containing amino acid either to cysteine and its key by-products glutathione, taurine, and sulfates or allows remethylation back to methionine to occur using either the Folate Cycle or the Trimethyl glycine (betaine) pathways.

    Figure 1 shows these metabolic pathways including the vitamins required at each step including vitamin B6 (as P-5-P), methylcobalamin, and 5-methyltetrahydrofolate (5-MTHF). In addition, it shows the key enzymes produced by the body at each step. These enzymes include CBS (cystathione beta synthase), BHMT (betaine homocysteine methyltransferase), MS (methionine synthase), and MTHFR (methylene tetrahydrofolate reductase).

    homocysteine metabolism diagram Figure 1. Metabolic Pathways in Methionine and Homocysteine Metabolism

    HEALTH ISSUES ASSOCIATED WITH HIGH HOMOCYSTEINE LEVELS

    It is highly important that the various metabolic pathways function correctly to keep homocysteine at healthy levels (6–8 µmol/L). Unfortunately, high levels of homocysteine in the body (10–20 µmol/L) are a factor in a wide range of health issues, including:

    • Greater risk for heart problems, including coronary artery disease, heart attacks, stroke, high blood pressure, congestive heart failure, and abnormal cholesterol levels. This is due to increased inflammation, sometimes due to blood clotting spontaneously, and because of blockages of the major arteries.
    • Mental abnormalities such as depression, anxiety, bipolar disorder, and other mental problems are more common among people with high homocysteine
    • Migraines and headaches in a significant percentage of the population
    • In those who suffer from high homocysteine due to having nutritional deficiencies anemia, aches and pains, hearing loss, age-related macular degeneration (ARMD), slowed development, and birth defects might also be possible
    • Greater risk for dementia, Alzheimer’s disease, brain atrophy, and other cognitive problems
    • In children, skeletal and developmental abnormalities including having a curved spine or protruding chest and rib cage. Some patients appear very tall and thin, and some might also have very long, thin “spider-like” toes and fingers.
    • Behavioral problems, including ADHD, autism and other learning disabilities

    ROLE OF GENETICS IN HOMOCYSTEINE METABOLISM

    Ten or more years ago, questions of how genetics enters into homocysteine metabolism were unlikely to be asked. However, in recent years DNA testing has advanced and is now available to everyone (for example, see my article about Bodysync's genetic test, GET STARTED – NUTRIGENOMIC TESTING.

    You may have heard a great deal about MTHFR (methylene tetrahydrofolate reductase). This gene is involved in folate metabolism and has a central role in methylation processes like repair of and building new DNA in dividing cells.

    In the remethylation pathway for conversion of homocysteine to methionine, MTHFR plays a key role in converting folate into 5-MTHF which is needed along with B12 as methylcobalamin in order for the conversion to take place. Genetic variations in MTHFR have been studied in depth. Of the many variations studies the most significant ones appear to be variations of C677C such as C677T (referred to as heterozygous) or T677T (referred to as homozygous). The heterozygous variant appears in about 30–50% of the population and causes somewhat less efficiency in the conversion of folic acid to 5-MTHF. However, the homozygous variation occurs in about 10% of the population and can have serious effects due to converting little homocysteine back to methionine.

    Another variation in MTHFR is called A1298A. These variations are A1298C and C1298C and will have similar effects to the C677C variations. It was interesting to me when I recently analyzed my Bodysync genetic test results showing I carry the variation A1298C (heterozygous), which indicates I may not be effectively converting homocysteine back to methionine.

    Additionally, my Bodysync genetic test results also indicate that I have heterozygous variations in the CBS enzyme shown in Figure 1, as well as heterozygous variations in MTR and MTRR enzymes, which are involved with B12 levels in the  remethylation pathway. These results indicate that I need to take higher levels of methylcobalamin and 5-MTHF.

    IMPORTANCE OF COENZYME FORMS AND PROPER AMOUNTS OF B VITAMINS

    Many of the B vitamins on the market today unfortunately are in synthetic form. The body can only use the natural coenzyme forms effectively. For example, the body needs vitamin B6 in the form of P-5-P (pyridoxal-5-phosphate), folate in the form of L-5-MTHF, and B12 in the form of methylcobalamin for proper metabolism of methionine. In some cases the body can use the synthetic forms of pyridoxine HCl, folic acid, and cyanocobalamin but pays a cost (e.g., in time and energy) by having to convert synthetic forms to coenzyme forms.

    Add to the prevalence of synthetic B vitamins, the fact that genetic deficiencies are more common than previously assumed, and it becomes clear that the coenzyme forms of B vitamins in the proper amounts are extremely important.

    Fortunately, I have always believed it best to include as many coenzyme forms as possible in the nutritional supplements I formulate (over the past 27 years). For example, all HPDI multivitamins include coenzymes of B1, B2, B6, B12, and folate (as 5-MTHF and folinic acid). This is uncommon in most multivitamin formulas on the market. For this reason our supplements are ideally suited to the prevention or resolution of most genetic problems regarding homocysteine.

    In addition, I have always chosen to include higher amounts than most multivitamins on the market. We also make available 5-MTHF one milligram (1 mg) capsules and methylcobalamin five milligram (5 mg) sublingual tablets. When genetic variations are in play as discussed above, then providing relatively higher amounts of coenzyme B vitamins that support important requirements in the body seems necessary.

    Interestingly, several other nutrients are involved in the pathways involving methionine and homocysteine. These include zinc, magnesium, and Vitamin B2. Our multivitamin formulas and magnesium formulas, especially Myo-Mag with its coenzyme B1, B2, and B6, are recommended to support these nutrient needs. Finally, it has been found that N-Acetyl-L-Cysteine (NAC) can significantly lower homocysteine (by up to 50%), most likely because its gives the body an excellent source of cysteine without have to use methionine.

    SUMMARY

    In this article, I have shown the value of the use of genetic testing and high-quality coenzyme B vitamins in resolving health issues associated with high values of homocysteine in the body.

     

    SOURCES & RESOURCES

     GET STARTED – NUTRIGENOMIC TESTING.

    FOLATE INGREDIENTS – FOLINIC ACID & 5-MTHF

    The Homocysteine Revolution by Kilmer S. McCully, MD

    "Role of hyperhomocysteinemia in endothelial dysfunction and atherothrombotic disease"
    (Cell Death and Differentiation 11, S56–S64)

    PRODUCTS

    5-MTHF
    (coenzyme folate)

    Methylcobalamin
    (vitamin B12)

    B-Complex-50

    HPDI Multivitamins

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